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| 1 | SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients显示文摘BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018.It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year.Despite decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(<50 years).Patients are often diagnosed at late stages of the disease and tend to have poor survival.We previously showed that the WNT“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon cancer.SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient survival.METHODS SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of California Santa Cruz Cancer Browser interface.RESULTS SFRP4 was found to be co-expressed with the EMT-linked markers CDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and COL1A1.SFRP4 expression negatively correlated with the EMTlinked suppressors CLDN4,CLDN7,TJP3,MUC1,and CDH1.The expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon cancer.Additionally,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).CONCLUSION Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy. | Landry E Nfonsam Jana Jandova Hunter C Jecius Pamela N Omesiete Valentine N Nfonsam | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 4 |
| 2 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 3 | Miscibility and mechanical properties of a ternary polymer blend: polystyrene/poly- carbonate/tetramethyl polycarbonate 显示文摘 | Landry C J T Cohrain B K | 1992 | Polymer1992，33，： | 1 |
| 4 | Synthesis of MCM-48 by a Phase Transformation Process显示文摘 | GALLIS K W LANDRY C C | 1997 | Chem Mater(S0897-4756)1997，9，10： | 1 |
| 5 | Pollinator-mediated competition between two co-flowering Neotropical mangrove species, Avicennia germinans (Avicenniaceae) and Laguncularia racemosa (Combretaceae) 显示文摘 | LANDRY C L | 2013 | Annals of Botany2013，111，2： | 1 |
| 6 | Stduy of heart and renal protection显示文摘 | Baigent C Landry M | 2006 | Kidney Int SupPl2006，，84： | 1 |
| 7 | Development of neural networks for weed recognition In corn fields 显示文摘 | Yang C C Prasher S O Landry J Ramaswarmy H S | 2002 | Transactions of the ASAE2002，45，3： | 1 |
| 8 | Dice with fair sums显示文摘 | LEWIS C Robertson RAE Michael Shortt STEPHEN G Landry | 1998 | The American Mathematical Monthly1998，95，4： | 1 |
| 9 | Decreased bone mineral density in men with metabolic syndrome alone and with type 2 diabetes显示文摘 | Yaturu S Humphrey S Landry C | 2009 | Med Sci Monit2009，15，： | 1 |
| 10 | Oxidation of octane and cyclohexane using a new porous substrate, Ti-MMM-1显示文摘 | Landry C C | 2002 | Micropor Mesopor Mat2002，52，： | 1 |
| 11 | The mechanisms leading to the useful electrical properties of polymer nanodielectrics显示文摘 | Smith R C Liang C Landry M | 2008 | IEEE Transactions on Dielec- trics and Electrical Insulation2008，15，1： | 1 |
| 12 | Integrated decision support system (DSS) for manure management & A review and perspective显示文摘 | Karmakar S Lague C Agnew J Landry H | 2007 | Computers and Electronics in Agncuhure2007，57，2： | 1 |
| 13 | Science Review: Vasopressin and the cardiovascular system part 2 -clinical physiology 显示文摘 | Holmes C L Landry D W Granton J T | 2004 | Crit Care2004，8，1： | 1 |
| 14 | Contribution of glial cells and percytes to the mRNA profiles of P-glycoprotein and muhidrug resistance-associated proteins in an vitro model of the BBB显示文摘 | Vincent B Landry C Ehouek MP | 2004 | Brain Research2004，1018，1： | 1 |
| 15 | Diffusion-based deprotection in mesoporous materials:a strategy for differential functionalization of porous silica particles显示文摘 | Cheng K Landry C C | 2007 | J Am Chem Soc2007，129，31： | 1 |
| 16 | Review of recent carrying capacity models for bivalve culture and recommendations for research and management 显示文摘 | McKindsey C W Thetmeyer H Landry T | 2006 | Aquaculture2006，261，： | 1 |
| 17 | Spheroidal aggregate culture of rat liver cells:histotypic reorganization,biomatrix deposition,and maintenance of functional activities显示文摘 | Landry J Bernier D Ouel et C | | 0，，03： | 1 |
| 18 | Mechanisms of Reactive Wetting: the Question of Triple Line Configuration显示文摘 | Landry K Rado C Voitovich R | 1997 | Acta ma- ter1997，45，： | 1 |
| 19 | The predic- tion and characterization of YshA, an unknown outer membrane protein from Salmonella typhimurium显示文摘 | Freeman T C Jr Landry S J Wimley W C | 2011 | Biochim Biophys Acta2011，1808，1： | 1 |
| 20 | The prediction and characterization of YshA, an unknown outer-membrane protein from Salmonella typhimurium显示文摘 | FREEMAN T C Jr LANDRY S J WIMLEY W C | 2011 | Biochim Biophys Acta2011，1808，1： | 1 |
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