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| 1 | Astragalus polysaccharide stimulates glucose uptake in L6 myotubes through AMPK activation and AS160/TBCID4 phosphorylation显示文摘 | Jian LIU Jing-fang ZHANG Jin-zhi LU De-ling ZHANG Ke LI Ke SU Jing WANG Ye-min ZHANG Nian WANG Si-tu YANG Lang BU Jing-ping OU-YANG | 2013 | Acta Pharmacologica Sinica2013，34，1： | 26 |
| 2 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 3 | PTEN-L promotes type I interferon responses and antiviral immunity显示文摘Phosphatase and tensin homolog deleted on chromosome ten(PTEN)is a well-known tumor suppressor that acts as a dual-specificity phosphatase and is frequently mutated in human cancer.Our previous work has demonstrated that PTEN also plays a vital role in type I interferon responses and antiviral innate immunity.Recently,a translational variant of PTEN with a long N-terminal extension(PTEN-L)has been discovered that is secreted into the extracellular environment and enters recipient cells,where it exerts a phosphatase function antagonistic to PI3K/Akt signaling and tumorigenesis.In this study,we demonstrate that PTEN-L promotes type I interferon responses and antiviral innate immunity during viral infection in a phosphatase activity-dependent manner.Compared with canonical PTEN,PTEN-L also exerts its antiviral function when it is applied exogenously in protein form.This finding was confirmed in cell cultures and mouse infection models.Furthermore,PTEN-L enhances the responses of both type I interferon and proinflammatory cytokines,thus suggesting that PTEN-L might possess additional functions compared with those of PTEN.Thus,the antiviral function of PTEN-L may open an avenue for the use of PTEN-L in antiviral therapy,particularly in patients with PTEN-deficient tumors. | Yuanyuan Cao Hongyun Wang Liu Yang Zhen Zhang Chenlin Li Xu Yuan Lang Bu Lang Chen Yu Chen Chun-Mei Li Deyin Guo | 2018 | Cellular & Molecular Immunology2018，15，1： | 3 |
| 4 | PTEN suppresses tumorigenesis by directly dephosphorylating Akt显示文摘Dear Editor,The serine-threonine kinase Akt plays a central role in regulating cell proliferation,migration,angiogenesis,transformation,energy metabolism,and death.1 The stimulation of growth factors recruits the PI3K to the plasma membrane and phosphatidylinositol-3A5-trisphosphate(PIP3),which in turn recruits Akt to the plasma membrane through PH domain of Akt. | Lang Bu Huan Wang Ji-an Pan Lang Chen Fan Xing Junyu Wu Shun Li Deyin Guo | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 5 | AGE STRUCTURES OF MODULES OF CLONAL PEATLAND SEDGE Carex middendorffii显示文摘Age structure of a plant population carries important information on population dynamics. The traditional age classification of individuals by development phases could not explain the generation relationship neither between individuals nor between modules, and it could not accurately predict the future of population or the tendency of peatland evolution. In a peatland of the Xiao Hinggan Mountains, China, at the middle of the growth season, the age structures of 3 modules, ramets, active buds and rhizomes of a Carex middendorffii clonal population were investigated, with the method of classifying age classes of ramets and active buds by counting generation quantity of tiller nodes, and classifying age classes of rhizomes by their real survival time. The quantity of vegetative ramets was dominant. Tiller nodes of ramets can propagate vegetatively for a maximum of 3 generations. The population of ramets consisted of 3 age classes of ramets at the middle of the growth season, and showed a stable age structure. In the two sampling events, there was no significant difference between quantities and age structure of the population. The maximum age of an excavated rhizome was 12 years old. Rhizomes were classified in 8 age classes, and age classes 4-6 contributed most to the total biomass. There was no significant difference in total length and total biomass per unit area, or in biomass per unit length in rhizomes between the two samplings. Four age classes of active buds were recognized, and their number increased from July to August. The Carex middendorffii clonal population achieved regeneration by budding from the tiller nodes of ramets. The age structures of the 3 modules suggested that the Carex middendorffii clonal population could persist in the early development phase of the oligotrophic peatland in the Xiao Hinggan Mountains, but it could not be dominant. It also faces the risk to disappear from the community as the peatland develops further. | BU Zhao-jun YANG Yun-fei Hakan RYDIN LANG Hui-qing | 2005 | Chinese Geographical Science2005，15，3： | 1 |
| 6 | Seroprevalence of Brucella infection in yaks (Bos grunniens) on the Qinghai- Tibet plateau of China显示文摘 | Lang X L Qu H L Bu Z Y | 2011 | Trop Anim Health Prod2011，43，2： | 1 |
| 7 | Primary extranodal CD8 positive epitheliotrupic T-cell lymphoma arising in a leiomyoma of the uterus 显示文摘 | Merz H Lange K Koch BU | 2003 | BJOG2003，110，5： | 1 |
| 8 | Seroprevalence of Brucella infection in yaks(Bos grunniens)on the Qinghai-Tibet Plateau of China显示文摘 | Lang X L Qu H L Bu Z Y | 2011 | Trop Anim Health Prod2011，43，： | 1 |
| 9 | Experimental study on thermal and mechanical properties of tailings-based cemented paste backfill with CaCl_(2)·6H_(2)O/expanded vermiculite shape stabilized phase change materials显示文摘CaCl_(2)·6H_(2)O/expanded vermiculite shape stabilized phase change materials(CEV)was prepared by atmospheric impregnation method.Using gold mine tailings as aggregate of cemented paste backfill(CPB)material,the CPB with CEV added was prepared,and the specific heat capacity,thermal conductivity,and uniaxial compressive strength(UCS)of CPB with different cement-tailing ratios and CEV addition ratios were tested,the influence of the above variables on the thermal and mechanical properties of CPB was analyzed.The results show that the maximum encapsulation capacity of expanded vermiculite for CaCl_(2)·6H_(2)O is about 60%,and the melting and solidification enthalpies of CEV can reach 98.87 J/g and 97.56 J/g,respectively.For the CPB without CEV,the specific heat capacity,thermal conductivity,and UCS decrease with the decrease of cement-tailing ratio.For the CPB with CEV added,with the increase of CEV addition ratio,the specific heat capacity increases significantly,and the sensible heat storage capacity and latent heat storage capacity can be increased by at least 10.74%and 218.97%respectively after adding 12%CEV.However,the addition of CEV leads to the increase of pores,and the thermal conductivity and UCS both decrease with the increase of CEV addition.When cement-tailing ratio is 1:8 and 6%,9%,and 12%of CEV are added,the 28-days UCS of CPB is less than 1 MPa.Considering the heat storage capacity and cost price of backfill,the recommended proportion scheme of CPB material presents cement-tailing ratio of 1:6 and 12%CEV,and the most recommended heat storage/release temperature cycle range of CPB with added CEV is from 20 to 40℃.This work can provide theoretical basis for the utilization of heat storage backfill in green mines. | Xiaoyan Zhang Tianrun Cao Lang Liu Baoyun Bu Yaping Ke Qiangqiang Du | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，2： | 1 |
| 10 | Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells显示文摘Nucleic acid-based systems play important roles in antiviral defense,including CRISPR/Cas that adopts RNA-guided DNA cleavage to prevent DNA phage infection and RNA interference(RNAi)that employs RNA-guided RNA cleavage to defend against RNA virus infection.Here,we report a novel type of nucleic acid-based antiviral system that exists in mouse embryonic stem cells(mESCs),which suppresses RNA virus infection by DNA-mediated RNA cleavage.We found that the viral RNA of encephalomyocarditis virus can be reverse transcribed into complementary DNA(vcDNA)by the reverse transcriptase(RTase)encoded by endogenous retrovirus-like elements in mESCs.The vcDNA is negative-sense single-stranded and forms DNA/RNA hybrid with viral RNA.The viral RNA in the heteroduplex is subsequently destroyed by cellular RNase H1,leading to robust suppression of viral growth. | Junyu Wu Chunyan Wu Fan Xing Liu Cao Weijie Zeng Liping Guo Ping Li Yongheng Zhong Hualian Jiang Manhui Luo Guang Shi Lang Bu Yanxi Ji Panpan Hou Hong Peng Junjiu Huang Chunmei Li Deyin Guo | 2021 | Cell Research2021，31，9： | 0 |
| 11 | Enhancing the singlet oxygen capture and release rate of metal-organic frameworks through interpenetration tuning显示文摘Recognized as one of the important active species involved in varicus ractions,singlet oxygen(^(1)O_(2))shows potential applications in chemical.blological,and environmental related fields.However,the con-trolled capture and release of^(1)O_(2)are still facing huge challenges due to its short lifetime and high re-activity.Herein,a framework-interpenetration tuning strategy was applied on a metal-organic framework(MOF)that aiming to improve the capture and release rate of O.The porosity of the MOF was remark-ably enhanced with the structural evolution from seven-fold(termed NKM-181)to six-fold interpene-tration(termed NKM-182),and the active anthracene sites became much mare accessible.Such drastic process can be achieved as simple as exchanging the primitive MOF in selected solvent and occurred surprisingly as single-crystal to single-crystal transformation.Also,additionally owing to the unblocked regular channels,NKM-182 shown significantly improved^(1)O_(2)trapping and releasing rates compared to strates an unprecedented regulation of^(1)O_(2)capture and release that of in NKM-181.This work demon process,along with achieving the highest^(1)O_(2)capture and release rate among reported porous materi-als.furthermore.the obtalned endoperoxides with^(1)O_(2)loaded(termed EPO-NKM-181 and EPO-NKM-182)can be used as a high efficiency smart material for anti-fake application. | Jing Hao Feifan Lang Liqin Hao Yi Yang Lulu Zhang Hao Zhang Quan-Wen Li Jiandong Pang Xian-He Bu | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 12 | The study of complex focussing acoustic field of a convex phased array probe used in ultrasonic diagnostic B-scanner显示文摘This paper reports a study of complex focussing acoustic fieldsof a convex phased array probe widely used in ultrasonic diagnosticB-scanner.The time delay necessary for electronic focussing and forgeometric focussing of complex focussing is given.By means ofHelmholtz‘s integral formula,the expressions of acoustic fields wereobtained for the electronic focussing and complex focussing.With simpson‘snumerical integral,a great deal of computations was carried out withan 86 /330 computer.By means of using different parameters,an optimum focal range and beam width of a 4 sequences electronic andcomplex focussing acoustic system was selected.With an EUB-40ultrasound diagnostic B-scanner produced by the Hitachi company,the lateral focussing acoustic field and lateral resolution in an echoic tankwere photographed by latticing method and the experimental result is con-sistent with the theory. | LANG Yifu,BU Shuzhong, JIANG Nanxiang and CAI Chongcheng(Harbin Shipbuilding Engineering Institute ) | 1991 | Chinese Journal of Acoustics1991，10，2： | 0 |
| 13 | Recent advances in metal-organic frameworks for oxygen evolution reaction electrocatalysts显示文摘The anodic oxygen evolution reaction(OER)can be combined with various cathodic reactions to enable the electrochemical synthesis of diverse chemicals and fuels,particularly in water electrolysis for hydrogen production.It is however exhibiting a high overpotential due to the sluggish four-electron transfer process,which is considered the decisive reaction in energy conversion systems.In recent years,metal-organic frameworks(MOFs)have emerged as the ideal catalysts for accelerating OER.This is primarily because of their orderly porous architecture,structural tailorability,and compositional diversity.This review systematically summarizes the recent research progress in pristine MOF electrocatalysts for OER,which covers the construction strategies and electrocatalytic performance of more than eight types of MOFs.Additionally,the partial/complete structural reconstructions and their effects on MOF-based OER electrocatalysts are highlighted.In particular,the development process of“discovery,explanation,and utilization”for the structural reconstructions of MOF electrocatalysts is outlined.Furthermore,the catalytic mechanisms are elaborated in detail,aiming to provide insight into the rational design and performance optimization of MOF-based OER electrocatalysts.The challenges and future perspectives of MOF-based OER electrocatalysts for industrial applications are also discussed. | Ming Liu Yin-Qiang Zhang Xuemin Wang Feifan Lang Na Li Xian-He Bu | 2023 | Science China Chemistry2023，66，10： | 0 |
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