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| 1 | Trans-arterial chemoperfusion for the treatment of liver metastases of breast cancer and colorectal cancer: Clinical results in palliative care patients显示文摘AIM To evaluate the clinical value and efficiency of transarterial chemoperfusion(TACP) in patients with liver metastases from breast cancer(BC) and colorectal cancer(CRC).METHODS We treated 36 patients with liver metastases of BC(n = 19, 19 females) and CRC(n = 17; 8 females, 9 males) with repeated TACP. The treatment interval was 4 wk. TACP was performed with gemcitabine(1000 mg/m2) and mitomycin(10 mg/m2), administered within 1 h after positioning the catheter tip in the hepatic artery. Before treatment, the size, location, tumour volume, vascularization and number of liver tumours were evaluated using magnetic resonance imaging(MRI). Tumour response was evaluated according to the Response Evaluation Criteria in Solid Tumors guidelines.RESULTS TACP using gemcitabine and mitomycin for metastases from CRC and BC was performed without any serious side effects. The follow-up MRI showed a therapeutic response in 84.2% of the BC patients-stable disease 47.4% and partial response 36.8%. A progression was seen in 15.8%.CRC patients showed a therapeutic response in 52.9% of cases. A progression of the disease was documented in 47.1% of the patients with CRC. These data show that TACP in patients with liver metastases of BC leads to a significantly better therapeutic response compared with CRC patients(P = 0.042). The median survival time was 13.2 mo for the BC patients, which is significantly longer than for CRC patients at 9.3 mo(P = 0.001).CONCLUSION TACP for liver metastases of BC appears to be a safe and effective palliative treatment with improved outcomes in comparison to patients with CRC. | Tatjana Gruber-Rouh Marcel Langenbach Nagy NN Naguib Nour-Eldin M Nour-Eldin Thomas J Vogl Stephan Zangos Martin Beeres | 2017 | World Journal of Clinical Oncology2017，8，4： | 7 |
| 2 | Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2显示文摘 | Loftin CD Tiano HF Langenbach R | 2002 | Prostag Lip Mediat2002，6869，： | 2 |
| 3 | Functional movemants of putative jaw muscle insertions显示文摘 | Goto TK Langenbach GE Korioth TW | | 0，，02： | 1 |
| 4 | A proposed COX-2 and PGE (2) receptor interaction in UV-exposed mouse skin显示文摘 | Chun KS Langenbach R | 2007 | Mol Carcinog2007，46，8： | 1 |
| 5 | Male-female differences in fertility and blood-pressure in ace-deficient mice显示文摘 | Krege JH John SW Langenbach LL | 1995 | Nature1995，375，6527： | 1 |
| 6 | Misoprostol in preventing postpartum hemorrhage: a meta-analysis 显示文摘 | LANGENBACH C | 2006 | Int J Gynaecol Obstet2006，92，1： | 1 |
| 7 | Agerelated changes in collagen properties~and mineralization in cancellous and cortical bone in the porcine mandibular condyle显示文摘 | Willems NMBK Langenbach GEJ Everts V | 2010 | Calcif Tissue Int2010，86，4： | 1 |
| 8 | The Prostaglandin E2Receptor,EP2,Regulate Survivin Expression Via an EGFR/STAT3 Pathway in UVB-Exposed Mouse Skin显示文摘 | Chun Kyung-Soo Langenbach | 2011 | Molecular Carcinogenesis2011，50，6： | 1 |
| 9 | 显示文摘 | OLDEROG M LANGENBACH M MICHEL O | 2004 | Laryngorhinootologie2004，83，： | 1 |
| 10 | Comparison of biomateri-als: three meshes and TAPP for inguinal hernia显示文摘 | Langenbach MR> Schmidt J Zimgibl H | 2006 | Surg Endosc2006，20，10： | 1 |
| 11 | Malignant transformation and anti-neoplastic actions of nonsteroidal anti-inflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts显示文摘 | ZHANG X MORHAM S G LANGENBACH R | 1999 | J Exp Med1999，190，4： | 1 |
| 12 | Prostaglandin E2 and microsomal prostaglandin E synthase-2 expression are decreased in the cyclooxygennase-2-deficient mouse brain despite compensatory induction of cyclooxygenase-1 and Ca2+ -dependent phospholipase A2显示文摘 | Bosetti F Langenbach R Weerasinghe G | 2004 | J Neurochem2004，91，6： | 1 |
| 13 | Mass properties of the pig mandible显示文摘 | Zhang F Langenbach GEJ Hannam AG | 2001 | J Dental Res2001，80，1： | 1 |
| 14 | Why there are two cyclooxygenase isozymes显示文摘 | Smith WL Langenbach R | 2001 | J Clin Investig2001，107，： | 1 |
| 15 | Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration 显示文摘 | Langenbach R Morham SG Tiano HF | 1995 | Cell1995，83，3： | 1 |
| 16 | Fiber-type composition of the human jaw muscles--(part 1) origin and functional significance of fiber-type diversity 显示文摘 | Korfage JA Koolstra JH Langenbach GE | 2005 | J Dent Res2005，84，9： | 1 |
| 17 | Safety,tolerability,pharmacokinetics,and pharmacodynamics of irbesartan after single and multiple doese in healthy male subjects显示文摘 | Marino MR Langenbacher KM Ford NF | 1997 | Clin Pharmacol Ther1997，61，： | 1 |
| 18 | Assessment of microsatellite instability and loss of heterozygosity in sporadic keratoacanthomas 显示文摘 | Langenbach N Kroiss MM Ruschoff J | 1999 | Arch Dermatol Res1999，291，1： | 1 |
| 19 | Why there are two cyclooxy- genase isozymes显示文摘 | Smith WL Langenbach R | 2001 | Clin lnvest2001，107，12： | 1 |
| 20 | The adaptive response of jaw muscles to varying functional demands 显示文摘 | Grtinheid T Langenbach GE Korfage JA | 2009 | Eur J Orthod2009，31，6： | 1 |
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