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| 1 | Nelfinavir,an HIV pro- tease inhibitor, induces apoptosis and cell cycle arrest in human cervical cancer cells via the ROS-dependent mi- tochondrial pathway 显示文摘 | Tong X Lanying D Petra P | 2015 | Cancer Letters2015，364，1： | 1 |
| 2 | Opposite clear corneal incisions on the steep meridian in phacoemulsification:early effects on the cornea显示文摘 | Tadros A Habib M Tejwani D von Lany H Thomas P | 2004 | J Cataract Refract Surg2004，30，2： | 1 |
| 3 | Infectious complications after gastrointestinal surgery in patients with ovarian carcinoma and malignant ascites显示文摘 | Donato D Angelides A Lani H | 1992 | Gynecol Oncol1992，44，： | 1 |
| 4 | An alternative approach to advancing resuscitation science显示文摘 | Karl B K Terence D V Lani L C | 2005 | Resuscitation2005，64，3： | 1 |
| 5 | TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing显示文摘 | Lanis J M Hightower L D Shen A | 2012 | Mol Microbiol2012，84，1： | 1 |
| 6 | Antisense expression of a cell wall-assoclated protein kinase, WAK4, inhibits cell elongation and alters morphology 显示文摘 | Lany D Ingmire P Tong H Y | 2001 | Plant Cell2001，13，6： | 1 |
| 7 | Opposite clear corneal incisions on the steep meridian in phacoemulsification:early effects on the cornea显示文摘 | Tadros A Habib M Tejwani D Von Lany H Thomas P | | 0，，02： | 1 |
| 8 | Validity and reliability of the observer's assessment of alertness/sedation scale:study with intravenous midazolam显示文摘 | CHERNIK D A GILLINGS D LANIE H | 1990 | J Clin Psychoparmacol1990，10，： | 1 |
| 9 | The Library department head in the context of matrix Management and reengineering显示文摘 | Bloss A Lanie D | 1997 | College & Research Libraries1997，58，6： | 1 |
| 10 | Allicin release under simulated gastrointestinal conditions from garlic powder tablets employed in clinical trials on serum cholesterol 显示文摘 | Lawson lany D Wang Z Jonathan Papadimitriou Dimitri | 2001 | Planta Medica2001，67，1： | 1 |
| 11 | Band-structure, optical properties, and defect physics of the photovoltaic semiconductor SnS 显示文摘 | Vidal J Lany S d' Avezac M | 2012 | Applied Physics Letters2012，100，03： | 1 |
| 12 | Opposite clear corneal incision on the steep meridian in phacoemulsifica- tion:early effects on the corneal 显示文摘 | Tadros A Habib M Tejwani D Von Lany H Thomas P | 2004 | J Cataract Refract Surg2004，30，2： | 1 |
| 13 | Band- Structure, Optical Properties, and Defect Physics of the Pho- tovohaic Semiconductor SnS 显示文摘 | Julien Vidal Stephan Lany Mayeul d' Avezac | 2012 | Applied Physics Letters2012，，： | 1 |
| 14 | Multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process显示文摘Red blood cells(RBCs)can act as carriers for therapeutic agents and can substantially improve the safety,pharmacokinetics,and pharmacodynamics of many drugs.Maintaining RBCs integrity and lifespan is important for the efficacy of RBCs as drug carrier.We investigated the impact of drug encapsulation by hypotonic dialysis on RBCs physiology and integrity.Several parameters were compared between processed RBCs loaded with l-asparaginase(“eryaspase”),processed RBCs without drug and non-processed RBCs.Processed RBCs were less hydrated and displayed a reduction of intracellular content.We observed a change in the metabolomic but not in the proteomic profile of processed RBCs.Encapsulation process caused moderate morphological changes and was accompanied by an increase of RBCs-derived Extracellular Vesicles release.Despite a decrease in deformability,processed RBCs were not mechanically retained in a spleen-mimicking device and had increased surface-to-volume ratio and osmotic resistance.Processed RBCs half-life was not significantly affected in a mouse model and our previous phase 1 clinical study showed that encapsulation of asparaginase in RBCs prolonged its in vivo half-life compared to free forms.Our study demonstrated that encapsulation by hypotonic dialysis may affect certain characteristics of RBCs but does not significantly affect the in vivo longevity of RBCs or their drug carrier function. | Mélanie Robert Bastien Laperrousaz Diana Piedrahita Emilie-Fleur Gautier Travis Nemkov Florian Dupuy Elie Nader Virginie Salnot Patrick Mayeux Angelo D’Alessandro Catherine Lavazec Philippe Joly Alexander Scheer Philippe Connes Agnès Cibiel | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
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