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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | 地表紫外辐射的变化显示文摘近年来紫外(UV)辐射测量的质量和数量已大大提高。不同仪器测量值之间的差异工减少到5%的量级。但长期变化的探测仍是一个问题,几乎没有历史数据可用来作本底的估计。所增加的UV辐射明显与南极春季臭氧减少相关。测量表明南极UV辐射极大值正好出现在夏至之前,南极洲Palmer站(64°S)春季臭氧耗损期间危害DNA的辐射可超过美国圣迭戈站(32°N)的夏季最高值。中纬度地区UV辐射增加较小。但对特定波长进行检查可发现,与1992/1993年北半球低柱臭氧量记录相联系的UV辐射增加是很明显的。阿根廷、智利、新西兰和澳大利亚的观测表明,这些地区的UV辐射水平比北半球相应纬度地区要高,平流层臭氧以及对流层污染的差别可能对此起了作用。对流层臭氧和气溶胶对UV-B总辐照度的减少作用是明显的。在一些地方,对流层污染自工业化前以来已有明显增加,这导致了地表UV辐射的减少。然而现在对流层污染变化对UV辐射变化的影响相对平流层臭氧减少的影响来说可能仅是一个小量。卫星测得的1979~1993年全球臭氧资料表明,在南北半球的中高纬度地区都有显著的UV-B辐射增加,而热带地区的变化小。然而这个估计的前提是在这段时期云和对流层污染保持不变。按照现在的氯氟烃(CFC)逐步禁止计划,全球UV辐射水平预计在本世纪末将达列峰值,这是与平流层氯含量出现峰值以及相应的臭氧耗损相联系的。可望在今后50年中逐步恢复到臭氧耗损之前的水平。 | Sasha Madronich Richard L.McKenzie Martyn M.Caldwell Lars Olof Bjrn 李卫 | 1995 | 人类环境杂志1995，24，3： | 3 |
| 3 | Shot-noise limited, supercontinuum-based optical coherence tomography显示文摘We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography(SD-OCT)with an axial resolution of 5.9μm at a center wavelength of 1370 nm.Current supercontinuumbased SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-topulse relative intensity noise of the supercontinuum source.To overcome this disadvantage,we have developed a low-noise supercontinuum source based on an all-normal dispersion(ANDi)fiber,pumped by a femtosecond laser.The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate.We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast,better sensitivity,and improved penetration.From SD-OCT imaging of skin,retina,and multilayer stacks we conclude that supercontinuumbased SD-OCT can enter the domain of shot-noise limited detection. | Shreesha Rao D.S. Mikkel Jensen Lars Grüner-Nielsen Jesper Toft Olsen Peter Heiduschka Björn Kemper Jürgen Schnekenburger Martin Glud Mette Mogensen Niels Møller Israelsen Ole Bang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 4 | 环境变化背景下北极生物的多样性、分布及其适应性显示文摘生物个体是对气候变化和紫外线B(UV-B)辐射变化产生反应的基础,而且这种反应会在各种时间尺度上发生。北极地区的动物、植物以及微生物种类的多样性从表面上看是低的,而且从北方针叶林到极地荒漠逐渐减少,但其原始物种却很丰富。与这种物种多样性随纬向梯度减少的趋势相反,一些空间分布范围很广的单一优势物神的优势度则呈增长趋势。全球气候变暖可能会减少该地区的物种多样性,并限制到这些物种的分布范围,尤其是在该地区生物分布的北部边缘,一些极地特有的动物和植物种类会面临着灭绝的危险。最有可能侵入苔原地带的物种是那些目前生存在极地外缘的北方地区生物。许多植物都具有自身的特征使它们能够在以下环境中生存;短暂的无冰雪覆盖的生长季节,低的太阳高度角,永久冻结地带及低的土壤温度,贫乏的养分获取条件以及极少的物理扰动。以上这些特征有些可能会限制当地物种对气候变暖的反应,但其最主要的因素是这些物种与那些潜在的入侵物种相比缺乏竞争能力。北极地区陆生动物拥有许多适应特性,这使它们能够适应北极地区剧烈的温度变化。许多动物通过冬眠或迁移来逃避极地地区的恶劣天气和资源短缺。北极地区动物生存的生物环境则相对简单:几乎没有天敌、竞争者、疾病、寄生生物,但同时食物资源也很短缺。极地陆生动物可能对由气候变化带来的温暖而干旱的夏季非常不适应,这种变化将会影响到动物的迁移路线、途中栖息地,并会改变冬季积雪的状况和冻融的循环过程。气候变化还会改变动物繁殖和发育的季节,并会引来新的竞争者、捕食者、寄生生物以及疾病等。极地微生物也能很好地适应该地区的气候:一些微生物甚至在-39℃的低温下还能进行代谢活动。蓝藻细菌和藻类生物有着很广泛的适应策略,这能够使它们避免(至少可以减少)紫外线的伤害。微生物能够忍受许多环境条件,而且其生长周期很短,这些特点将使它们能很快适应新的生存环境。与此形成对比的是,极地植物和动物很可能通过改变其分布范围而不是积极的生物进化来适应环境的变暧。 | Terry V.Callaghan Lars Olof Bjrn Yuri Chernov Terry Chapin Torben R.Christensen Brian Huntley Rolf A.Ims Margareta Johansson Dyanna Jolly Sven Jonasson Nadya Matveyeva Nicolai Panikov Walter Oechel Gus Shaver Josef Elster Heikki Henttonen Kari Laine Kari Taulavuori Erja Taulavuori Christoph Zckler 何永涛 | 2004 | AMBIO-人类环境杂志2004，33，B11： | 2 |
| 5 | Genome sequence of a food spoilage lactic acid bacterium, Leuconostoc gasicomitatum LMG 18811T, in association with specific spoilage reactions 显示文摘 | PER JOHANSSON LARS PAULIN K JOHANNA BJ?RKROTH | 2011 | Appl Environ Microb2011，77，43： | 1 |
| 6 | Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction显示文摘 | Lars Gullestad Stein ?rn Kenneth Dickstein Christian Eek Thor Edvardsen Svend Aakhus Erik T. Askevold Annika Michelsen Bj?rn Bendz Rita Sk?rdal Hans-J?rgen Smith Arne Yndestad Thor Ueland P?l Aukrust | 2012 | International Journal of Cardiology2012，，： | 1 |
| 7 | Color-stable, ITO-free white organic light-emitting diodes with enhanced efficiency using solution-processed transparent electrodes and optical outcoupling layers显示文摘 | Hong-Wei Chang Yong Hyun Kim Jonghee Lee Simone Hofmann Bj?rn Lüssem Lars Müller-Meskamp Malte C. Gather Karl Leo Chung-Chih Wu | 2014 | Organic Electronics2014，，5： | 1 |
| 8 | Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study显示文摘 | Sten Nilsson Lars Franzén Christopher Parker Christopher Tyrrell René Blom Jan Tennvall Bo Lennern?s Ulf Petersson Dag C Johannessen Michael Sokal Katharine Pigott Jeffrey Yachnin Michael Garkavij Peter Strang Johan Harmenberg Bj?rg Bolstad ?yvind S Brula | 2007 | Lancet Oncology2007，，7： | 1 |
| 9 | Toxicity and 7-ethoxyresorufin O-deethylase-inducing potency of coplanar polychlorinated biphenyls (PCBs) in chick embryos显示文摘 | Bj?rn Brunstr?m Lars Andersson | 1988 | Archives of Toxicology1988，，4： | 1 |
| 10 | Sensitive troponin assaysand NT-proBNP in acute coronary syndrome: prediction of significant coronary lesions and long-term prognosis显示文摘 | J?rgen Gravning Marit Kristine Smedsrud Torbj?rn Omland Christian Eek Helge Skulstad Lars Aaberge Bj?rn Bendz John Kjekshus Lars M?rkrid Thor Edvardsen | 2013 | American Heart Journal2013，，： | 1 |
| 11 | 增强的紫外线B辐射对副极地石南灌丛生态系统的影响显示文摘为了研究增强紫外线B辐射对天然的副极地生态系统的影响,在瑞典北部的阿比斯库进行了实地辐照试验。样方中的植被由低矮的灌木层和它下面的苔藓和地衣组成。对这些样方内植被和土壤的许多反应变量,诸如光合作用、生长、物候、品种组成和分解的变化等都作了测定。这份报告介绍采用的方法和一些初步结果。分解作用被增强的紫外线B辐射削弱。紫外线B直接影响分解过程并通过改变叶的组织化学成分产生间接影响。在增强的紫外线B的条件下,低矮灌木的年生长较慢。常绿树种比落叶树种所受影响更明显。低矮灌木的叶片厚度被紫外线B改变。常绿灌木越桔(Vaccinium vitis-idaea)的叶片长得较厚,而两种落叶灌木欧洲越桔(V.myrtillus)和驾斯越桔(V.uliginosum)的叶片长得较薄。在苔藓中,多育糙藓(Hylocomium splendens)在增强的紫外线 B辐射下物候发育加快。其生长(主枝的数目、长度和干重)也增加了。 | UIf Johanson Carola Gehrke Lars Olof Bjrn Terry V.Callaghan Mats Sonesson 郑斯中 | 1995 | 人类环境杂志1995，24，2： | 1 |
| 12 | Knowledge bases and regional innovation systems: Comparing Nordic clusters显示文摘 | Bj?rn T. Asheim Lars Coenen | 2005 | Research Policy2005，，8： | 1 |
| 13 | Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization显示文摘 | Tuva B. Dahl Arne Yndestad Mona Skjelland Erik ?ie Arve Dahl Annika Michelsen Jan K. Dam?s Siv H. Tunheim Thor Ueland Camilla Smith Bj?rn Bendz Serena Tonstad Lars Gullestad Stig S. Fr?land Kirsten Krohg-S?rensen David Russell P?l Aukrust Bente Halvorsen | 2007 | Circulation2007，，8： | 1 |
| 14 | The majority of nondipping men do not have increased cardiovascular risk: a population-based study显示文摘 | Kristina Bj?rklund Lars Lind Bertil Andrén Hans Lithell | 2002 | Journal of Hypertension2002，，8： | 1 |
| 15 | 温度对UV-B诱导的烟草叶圆片DNA损伤的影响显示文摘环丁烷嘧啶二聚体(CPD)和6-4光产物(6-4PP)是两种主要的UV-B诱导的DNA光损伤产物。利用单克隆抗体酶联免疫吸附分析法(ELISA),研究了温度对UV-B诱导的烟草叶圆片DNA损伤的影响。室温(24℃)条件下,UV-B处理引起了烟草叶圆片DNA中CPD和6-4PP的积累。0℃条件下,UV-B处理的烟草叶圆片DNA中CPD和6-4PP的积累比室温下分别降低了9.8%和12%。UV-B诱导的DNA损伤曾被认为是纯粹的光化学过程而与不受温度影响,而本实验结果表明,UV-B诱导的烟草叶圆片DNA形成CPD和6-4PP的过程具有温度依赖性。这一特性有利于植物对全球变化的适应,因而具有重要的生态学意义。 | 李韶山 王艳 Lars Olof Bjrn | 2002 | 生态科学2002，21，2： | 1 |
| 16 | Proteasome inhibition causes nigral degeneration with inclusion bodies in rats显示文摘 | Kevin St. P. McNaught Lars M. Bj?rklund Roger Belizaire Ole Isacson Peter Jenner C. Warren Olanow | 2002 | Neuroreport2002，，11： | 1 |
| 17 | Enhancing performance in anaerobic high-solids stratified bed digesters by straw bed implementation显示文摘 | Svensson Lars Mattias Bj?rnsson Lovisa Mattiasson Bo | 2006 | Bioresource Technology2006，98，1： | 1 |
| 18 | Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization显示文摘 | Tuva B. Dahl Arne Yndestad Mona Skjelland Erik ?ie Arve Dahl Annika Michelsen Jan K. Dam?s Siv H. Tunheim Thor Ueland Camilla Smith Bj?rn Bendz Serena Tonstad Lars Gullestad Stig S. Fr?land Kirsten Krohg-S?rensen David Russell P?l Aukrust Bente Halvorsen | 2007 | Circulation2007，，8： | 1 |
| 19 | Prevalence of colonic neoplasia and advanced lesions in the normal population: a prospective population-based colonoscopy study显示文摘 | Anna M Forsberg Lars Kjellstr? m Lars Agré us Anna Nixon Andreasson Henry Nyhlin Nicholas J Talley Erik Bj? rck | 2012 | Scandinavian Journal of Gastroenterology2012，，2： | 1 |
| 20 | Clinical features and determinants of VO_(2peak) in de novo heart transplant recipients显示文摘AIM To study exercise capacity and determinants of early peak oxygen consumption(VO_(2peak)) in a cohort of de novo heart transplant(HTx) recipients. METHODS To determine possible central(chronotropic responses, cardiopulmonary and hemodynamic function) and peripheral factors(muscular exercise capacity and body composition) predictive of VO_(2peak), a number of different measurements and tests were performed, as follows: Cardiopulmonary exercise testing(CPET) was performed mean 11 wk after surgery in 81 HTx recipients > 18 years and was measured with breath by breath gas exchange on a treadmill or bicycle ergometer. Metabolic/respiratory measures include VO_(2peak) and VE/VCO2 slope. Additional measures included muscle strength testing, bioelectrical impedance analysis, echocardiography, blood sampling and health-related quality of life. Based on the VO_(2peak)(mL/kg per minute) median value, the study population was divided into two groups defined as a low-capacity group and a high-capacity group. Potential predictors were analyzed using multiple regression analysis with VO_(2peak)(L/min) as the dependent variable.RESULTS The mean ± standard deviation(SD) age of the total study population was 49 ± 13 years, and 73% were men. This de novo HTx cohort demonstrated a median VO_(2peak) level of 19.4 mL/kg per min at 11 ± 1.8 wk postHTx. As compared with the high-capacity group, the low-capacity group exercised for a shorter time, had lower maximal ventilation, O_2 pulse, peak heart rate and heart rate reserve, while the VE/VCO_2 slope was higher. The low-capacity group had less muscle strength and muscular exercise capacity in comparison with the highcapacity group. In order of importance, O_2 pulse, heart rate reserve, muscular exercise capacity, body mass index, gender and age accounted for 84% of the variance in VO_(2peak)(L/min). There were no minor or major serious adverse events during the CPET. CONCLUSION Although there is great individual variance among de novo HTx recipients, early VO_(2peak) measures appear to be influenced by both central and peripheral factors. | Katrine Rolid Arne K Andreassen Marianne Yardley Elisabeth Bj?rkelund Kristjan Karason Julia P Wigh Christian H Dall Finn Gustafsson Lars Gullestad Kari Nytr?en | 2018 | World Journal of Transplantation2018，8，5： | 1 |
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