|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment显示文摘 | Musselman DL Betan E Larsen H | 2003 | Biol Psychiatry2003，54，3： | 1 |
| 3 | Genes that regulate both development and longevity in caenorhabditis elegans显示文摘 | Larsen PL Albert PS Riddle DL | 1995 | Genetics1995，139，： | 1 |
| 4 | Uhrastructural analysis of pressuretreated human hypertrophic scars显示文摘 | Baur PS Larsen DL Stacey HR | 1976 | J Trauma1976，16，8： | 1 |
| 5 | Relationship of depressionto diabetes types 1 and 2 : Epidemiology, biology, and treatment 显示文摘 | Musselman DL Betan E Larsen H rt al | 2003 | Hoi Psychiatry2003，54，3： | 1 |
| 6 | Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment显示文摘 | Musselman DL Betan E Larsen H | 2003 | Biol Psychiatry2003，54，3： | 1 |
| 7 | Prevalence and the duration of linear enamel hypoplasia:A comparative study of Neandertals and Inuit foragers显示文摘 | Guatelli-Steinberg D Larsen CS Hutchinson DL | 2004 | Journal of Human Evolution2004，47，1： | 1 |
| 8 | A systematic review of salvage therapy to patients with metastatic colorectal cancer previously treated with fluorouracil,oxaliplatin and irinotecan+/-targeted therapy显示文摘 | Nielsen DL Palshof JA Larsen FO | 2014 | Cancer Treat Rev2014，40，6： | 1 |
| 9 | Immunization of pigs against influenza virus infection by DNA vaccine priming followed by killed- virus vaccine boosting 显示文摘 | Larsen DL Karasin A Olsen CW | 2001 | Vaccine2001，19，2022： | 1 |
| 10 | Relationship of depres- sion to diabetes types 1 and 2: epidemiology, biology, and treat- ment 显示文摘 | Musselman DL Betan E Larsen H | 2003 | Biological Psychiatry2003，54，3： | 1 |
| 11 | Relationship of depression to diabetes types 1 and 2 : epidemiology, biology, and treatment 显示文摘 | Musselman DL Betan E Larsen H | 2003 | Bio Psychiatry2003，54，： | 1 |
| 12 | A systematic review of salvage therapy to patients with metastatic colotctal cancer previ- ously treated with fluorouracil, oxaliplatin and irinotecan + / - tar- geted therapy显示文摘 | Nielsen DL Palshof JA Larsen FO et 81 | 2014 | Cancer Treat Roy2014，40，6： | 1 |
| 13 | Systematic review of trastuzumab and lapatinib in the treatment of women with brain metastases from HER2-positive breast cancer显示文摘 | Larsen PB Kümler I Nielsen DL | 2013 | Cancer Treat Rev2013，39，70： | 1 |
| 14 | Relationship of depression to diabetes types 1 and 2:epidemiology,biology,and treatment显示文摘 | Musselman DL Betan E Larsen H | 2003 | Biol Psychiatry2003，54，3： | 1 |
| 15 | Clinical Practice Guidelines for the Management of Cryptococcal Disease:2010 Update by the Infectious Diseases Society of America显示文摘 | Perfect JR Dismukes WE Dromer F Goldman DL Graybill JR Hamill RJ Harrison TS Larsen RA Lortholary O Nguyen MH Pappas PG Powderly WG Singh N Sobel JD Sorrell TC | 2010 | Clin Infect Diss2010，50，3： | 1 |
| 16 | Genes that regulate both devel-opment and longevity in Caenorhabditis elegans 显示文摘 | Larsen PL Albert PS Riddle DL | 1995 | Genetics1995，139，4： | 1 |
| 17 | A systematic review of salvage therapy to patients with metastatic eolorectal cancer previ- ously treated with fluorouracil, oxaliplatin and irinotecan +/- targeted therapy显示文摘 | Nielsen DL Palshof JA Larsen FO | 2014 | Cancer Treat Rev2014，40，6： | 1 |
| 18 | Relationship of de- pression to diabetes types 1 and 2:epidemiology,biology, and treatment显示文摘 | Musselman DL Betan E Larsen H | 2003 | Biol Psychiatry2003，54，3： | 1 |
| 19 | Relationship of depressionto diabetes types 1 and 2 : epidemiology,biology, and treatment显示文摘 | Musselman DL Betan E Larsen H | 2003 | Biol Psychiatry2003，54，： | 1 |
| 20 | A systematic review of trastuzumab and lapatinib in the treatment of women with brain metastases from HER2-positive breast cancer显示文摘 | Larsen PB Kumler I Nielsen DL | 2013 | Cancer Treat Rev2013，39，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员