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| 1 | WJD 5^(th) Anniversary Special Issues(2): Type 2 diabetes Effects of exercise training on mitochondrial function in patients with type 2 diabetes显示文摘Type 2 diabetes is characterized by a decreased ability of insulin to facilitate glucose uptake into insulin sensitive tissue,i.e.,skeletal muscle.The mechanism behind this is at the moment unresolved.It has been suggested that increased amount of lipids inside the skeletal muscle(intramuscular triglyceride,diacylglycerol and ceramides)will impair insulin action in skeletal muscle,but data are not consistent in the human literature.It has also been hypothesized that the impaired insulin sensitivity is due to a dysfunction in the mitochondria resulting in an impaired ability to oxidize lipids,but the majority of the literature is not supporting this hypothesis.Recently it has been suggested that the production of reactive oxygen species play an essential role in skeletal muscle insulin sensitivity.It is well accepted that physical activity(endurance,strength and high intensity training)improves insulin sensitivity in healthy humans and in patients with type 2 diabetes.Whether patients with type 2 diabetes have the same beneficial effects(same improvement)as control subjects,when it comes to regular physical activity in regard to mitochondrial function,is not established in the literature.This review will focus only on the effect of physical activity on skeletal muscle(mitochondrial function)in patients with type 2 diabetes. | Steen Larsen Stinna Skaaby J rn W Helge Flemming Dela | 2014 | World Journal of Diabetes2014，5，4： | 2 |
| 2 | The Permo-Carboniferous Oslo Rift through six stages and 65 million years显示文摘 | BjФrn T. Larsen Snorre Olaussen BjФrn Sundvoll Michel Heeremans | 2008 | Episodes2008，31，1： | 2 |
| 3 | 13C-NMR studies of monomeric composition and sequence in alginate 显示文摘 | Hans Grasdalen Bjφrn Larsen Olav Smidsrφd | 1981 | Carbohydr Res1981，89，： | 1 |
| 4 | Anomalies of the coronary arteries originating from the right sinus of Valsalva显示文摘 | Alf Inge Larsen Stein ?rn St?le Barvik Dennis W.T. Nilsen | 2006 | International Journal of Cardiology2006，，2： | 1 |
| 5 | Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects显示文摘 | Steen Larsen Joachim Nielsen Christina Neigaard Hansen Lars Bo Nielsen Flemming Wibrand Nis Stride Henrik Daa Schroder Robert Boushel J?rn Wulff Helge Flemming Dela Martin Hey‐Mogensen | 2012 | The Journal of Physiology2012，，14： | 1 |
| 6 | REPAIR OF GIANT INCISIONAL HERNIAS WITH POLYPROPYLENE MESH: A RETROSPECTIVE STUDY显示文摘 | Jaime Rodriguez San Pio Tine Engberg Damsgaard Ole Momsen Villadsen Ivan J?rn Larsen | 2003 | Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery2003，，2： | 1 |
| 7 | Ultrasonographic study of mechanosensory properties in human esophagus during mechanical distension显示文摘瞄准:在远侧的食管在控制卷的斜面扩张期间用内视镜的 ultrasonography 学习食道的几何学和 mechanosensation。方法:12 个健康志愿者经历了一只袋子的扩张。在直到中等疼痛的扩张期间,感觉紧张在视觉类似物规模(管) 上被估计。食道的变丑在不同体积和管层次以多维的段比率和紧张被计算。扩张被做在前并且在反副交感神经生理的药丁基莨菪胺的管理期间。结果:刺激反应(体积 -- 管) 没有或与丁基的管理,曲线没不同莨菪胺。段比率的分析在纵的方向在环绕的方向,在光线的方向的压缩和小张力的段表明了张力的段。一个紧张坡度在粘膜表面与最大的环绕的变丑在整个食道的墙存在。感觉紧张作为紧张的功能指数地增加了。结论:方法提供相关到感觉紧张的食道的变丑坡度的信息。因此,在人的食管学习 mechanosensation 能被用来。进一步的研究被需要为食道的 mechanoreceptors 决定准确变丑刺激。 | Ejnar Larsen Hariprasad Reddy AsbjΦrn Mohr Drewes Lars Arendt-Nielsen Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，28： | 1 |
| 8 | Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects显示文摘 | Steen Larsen Joachim Nielsen Christina Neigaard Hansen Lars Bo Nielsen Flemming Wibrand Nis Stride Henrik Daa Schroder Robert Boushel J?rn Wulff Helge Flemming Dela Martin Hey‐Mogensen | 2012 | The Journal of Physiology2012，，14： | 1 |
| 9 | Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet显示文摘 | Morten M?ller Poulsen Jens ?. Larsen Stephen Hamilton-Dutoit Berthil F. Clasen Niels Jessen S?ren K. Paulsen Thomas N. Kj?r Bj?rn Richelsen Steen B. Pedersen | 2012 | Nutrition Research2012，，9： | 1 |
| 10 | Resveratrol up-regulates hepatic uncoupling protein 2 and prevents development of nonalcoholic fatty liver disease in rats fed a high-fat diet显示文摘 | Morten M?ller Poulsen Jens ?. Larsen Stephen Hamilton-Dutoit Berthil F. Clasen Niels Jessen S?ren K. Paulsen Thomas N. Kj?r Bj?rn Richelsen Steen B. Pedersen | 2012 | Nutrition Research2012，，9： | 1 |
| 11 | Comparison of fin-and-tube interlaced and face split evaporators with flow maldistribution and compensation显示文摘 | Martin Ryhl K?rn Brian Elmegaard Lars Finn Sloth Larsen | 2013 | International Journal of Refrigeration2013，，1： | 1 |
| 12 | The effect of highprotein,low-carbohydrate diets in the treatment of type 2diabetes:a 12 month randomised controlled trial显示文摘 | Larsen RN Mann NJ Maclean E | 2011 | Diabetologia2011，54，4： | 1 |
| 13 | The effect of high- protein, low-carbohydrate diets in the treatment of type 2 diabetes: a 12 month randomised controlled trial 显示文摘 | Larsen RN Mann N J Maclean E | 2011 | Diabetologia2011，54，： | 1 |
| 14 | Non-homologous functions of the AlkB homologs显示文摘TheDNArepair enzyme AlkB was identified in E.coli more than three decades ago.Since then,nine mammalian homologs,all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases,have been identified(designated ALKBH1–8 and FTO).While E.coli AlkB serves as a DNA repair enzyme,only two mammalian homologs have been confirmed to repair DNA in vivo.The other mammalian homologs have remarkably diverse substrate specificities and biological functions.Substrates recognized by the different AlkB homologs comprise erroneous methyl-and etheno adducts in DNA,unique wobble uridine modifications in certain tRNAs,methylated adenines in mRNA,and methylated lysines on proteins.The phenotypes of organisms lacking or overexpressing individual AlkB homologs include obesity,severe sensitivity to inflammation,infertility,growth retardation,and multiple malformations.Here we review the present knowledge of the mammalian AlkB homologs and their implications for human disease and development. | Rune Ougland Torbjørn Rognes Arne Klungland Elisabeth Larsen | 2015 | Journal of Molecular Cell Biology2015，7，6： | 0 |
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