|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells显示文摘AIM: To analyze the ability of nine different potentially probiotic bacteria to induce maturation and cytokine production in human monocyte-derived dendritic cells (moDCs). METHODS: Cytokine production and maturation of moDCs in response to bacterial stimulation was analyzed with enzyme-linked immunosorbent assay (ELISA) and flow cytometric analysis (FACS), respectively. The kinetics of mRNA expression of cytokine genes was determined by Northern blotting. The involvement of different signaling pathways in cytokine gene expression was studied using specific pharmacological signaling inhibitors. RESULTS: All studied bacteria induced the maturation of moDCs in a dose-dependent manner. More detailed analysis with S. thermophilus THS, B. breve Bb99, and L. lactis subsp. cremoris ARH74 indicated that these bacteria induced the expression of moDC maturationmarkers HLA class Ⅱ and CD86 as efficiently as pathogenic bacteria. However, these bacteria differed in their ability to induce moDC cytokine gene expression. S. thermophilus induced the expression of pro-inflammatory (TNF-α, IL-12, IL-6, and CCL20) and Th1 type (IL-12 and IFN-γ) cytokines, while B. breve and L. lactis were also potent inducers of anti- inflammatory IL-10. Mitogen-activated protein kinase (MAPK) p38, phosphatidylinositol 3 (PI3) kinase, and nuclear factor-kappa B (NF-κB) signaling pathways were shown to be involved in bacteria-induced cytokine production. CONCLUSION: Our results indicate that potentially probiotic bacteria are able to induce moDC maturation, but their ability to induce cytokine gene expression varies significantly from one bacterial strain to another. | Sinikka Latvala Taija E Pietil Ville Veckman Riina A Kekkonen Soile Tynkkynen Riitta Korpela Ilkka Julkunen | 2008 | World Journal of Gastroenterology2008，14，36： | 8 |
| 2 | Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults显示文摘AIM: To evaluate the effects of three potentially anti- inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults. | Riina A Kekkonen Netta Lummela Heli Karjalainen Sinikka Latvala Soile Tynkkynen Salme Jrvenp Hannu Kautiainen Ilkka Julkunen Heikki Vapaatalo Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，13： | 6 |
| 3 | Expression of cellular fibronectin and tenascin in the rabbit cornea after excimer laser photorefractive keratectomy:a 12 month study显示文摘 | Latvala T Tervo K Mustonen R | 1995 | Br J Ophthalmol1995，79，： | 2 |
| 4 | Influnence of iridectomy on the tea film显示文摘 | Latvala T Barraquer C | 1993 | Ophthalmic Surg1993，，： | 1 |
| 5 | Genetic influences on physical activity in young adults:a twin study 显示文摘 | Mustelin L Joutsi J Latvala A | 2012 | Med Sci Sports Exerc2012，44，7： | 1 |
| 6 | Minimizers of the variable exponent, non-uniformly convex Dirichlet energy 显示文摘 | HARJULEHTO P HASTO P LATVALA V | 2008 | International Jour- nal of Pure and Applied Mathematics2008，，89： | 1 |
| 7 | Genetic influenceson physical activity in young adults : a twin study 显示文摘 | Mustelin L Joutsi J Latvala A | 2012 | Med Sci Sports Exerc2012，44，7： | 1 |
| 8 | Efficacy of coldgel for soft tissue injuries : a prospective randomized double - blin-ded trial 显示文摘 | Airaksinen OV Kyrklund N Latvala K | 2003 | Am J Sports Med2003，31，： | 1 |
| 9 | Predictive factors for neck and shoulder pain:a longitudinal study in young adults显示文摘 | Siivola SM Levoska S Latvala K | 2004 | Spine2004，29，15： | 1 |
| 10 | Histone acetyltrauferase / deacetyltranferase and cancer: an open and short case 显示文摘 | Latvala J Parkkila S Melkko J | 2001 | Mol Med2001，1，4： | 1 |
| 11 | An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample 显示文摘 | Bogl LH Latvala A Kaprio J | 2011 | J Bone Miner Res2011，26，： | 1 |
| 12 | Porous carriers for biomedical applications based on alginate hydrogels显示文摘 | Eiselt P Yeh J Latvala RK | | 0，，： | 1 |
| 13 | Influence of iridectomy on the tear film显示文摘 | Latvala T Barraquer C | 2003 | Ophthalmic Sury2003，20，2： | 1 |
| 14 | Anaemia and other predictors of fatigue among patients on palliative therapy for advanced cancer显示文摘 | Latvala A Syrj(a)nen K Salmenoja H | | 0，，07： | 1 |
| 15 | Corneal wound healing and nerve morphology after exeimer laser in situ keratomileusis in human eyes显示文摘 | Latvala T Barraquer-Coll C Tervo K | 1996 | J Refract Surg1996，12，6： | 1 |
| 16 | Immune responses to ethanol metabolites and cytokine profiles differentiate alcoholics with or without liver disease显示文摘 | Latvala J Hietala J Koivisto H | | 0，，06： | 1 |
| 17 | Simple measurements in assessing muscle performance after an ACL reconstruction显示文摘 | Jarvela T Kannus P Latvala K | 2002 | Int J Sports Med2002，23，3： | 1 |
| 18 | Multilayer intermittent sand filter显示文摘 | Latvala A | 1993 | Wat Sci Tech1993，28，10： | 1 |
| 19 | Biomarkers of alcohol consumption in patients classified according to the degree of liver disease severity显示文摘 | Anttila P Jarvi K Latvala J | 2005 | Scand J Clin Lab Invest2005，65，2： | 1 |
| 20 | Cell mediated immune response during primary Chlamydia pneumoniae infection显示文摘 | Halme S Latvala J Karttunen R | 2000 | Infect Immun2000，68，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员