|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rapid and efficient reprogramming of human fetal and adult blood CD34~ cells into mesenchymal stem cells with a single factor显示文摘进体的干细胞的皮房间的直接变换在再生药打开了新治疗学的可能性。这里,我们证明人的导致的间充质的干细胞(iMSCs ) 能高效地从绳索血(CB ) 被产生 - 或由有一个单个因素的直接 reprogramming 的成年的外部血(PB )-CD34+ 房间, OCT4。面对一个 GSK3 禁止者, 16% OCT4-transduced CD34 + 房间在 2 个星期以内被变换成 iMSCs。有效直接 reprogramming 与两 episomal 被完成调停向量的短暂 OCT4 表示和 lentiviral 调停向量的 OCT4 transduction。iMSCs 快车 MSC 标记,类似于骨头髓(BM ) 在形态学的 -MSCs,并且在 vitro multilineage 区别能力拥有,还与 BM-MSCs 相比有一个更大的 proliferative 能力。类似于 BM-MSCs,植入的 iMSCs 形式骨头和结缔组织,并且是在老鼠的 non-tumorigenic。然而, BM-MSCs 不而 iMSCs 确实形成肌肉纤维,显示 iMSCs 的一个潜在的功能的优点。另外,我们观察到 OCT4 表示的高水平为起始的 reprogramming 和最佳的 iMSC 自强被要求,当 OCT4 表示的减小为 multilineage 区别被要求时。我们的方法将贡献病人特定的 iMSCs 的产生,它能在再生药有应用。这发现可以也为血房间的直接变换便于策略的发展进临床的重要性的房间的另外的类型。 | Xianmei Meng Rui-Jun Su David J Baylink Amanda Neises Jason B Kiroyan Wayne Yuk-Wai Lee Kimberly J Payne Daila S Gridley Jun Wang K-H William Lau Gang Li Xiao-Bing Zhang | 2013 | Cell Research2013，23，5： | 2 |
| 2 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 3 | Effect of Milk Fat on the Stability of Vitamin A in Ultra-High Temperature Milk 显示文摘 | LAU B L T KAKUDA Y ARNOTT D R | 1986 | J Dairy Sci1986，69，： | 1 |
| 4 | Deoxycholic acid activates protein kinase C and phospholipase C via increased Ca^2+ entry at plasma membrane显示文摘 | Lau B W Colella M Ruder W C | 2005 | Gastroenterology2005，128，3： | 1 |
| 5 | Sound alters visual motion pereeption显示文摘 | Sekuler R Sekuler A B Lau T | 1997 | Nature1997，385，6614： | 1 |
| 6 | Remote sea surface variations during ENSO: evidence for a tropical atmospheric bridge显示文摘 | KLEIN S A SODEN B J LAU N C | 1999 | J Clim1999，12，： | 1 |
| 7 | Robust fixture configuration design for sheet metal assembly with laser welding显示文摘 | Li Bing Shiu B W Lau K J | 2003 | Journal of Manufacturing Science and Engineering2003，125，1： | 1 |
| 8 | Polycrystalline ZnO thin films on Si (100) deposited by filtered cathodic vacuum arc 显示文摘 | XU X L LAU S P CHEN J S CHEN G Y TAY B K | 2001 | Journal of Crystal Growth2001，223，12： | 1 |
| 9 | Bone mineral density reference norms for Hong Kong Chinese 显示文摘 | Lynn HS Lau EMC Au B | 2005 | Osteoporos Ints2005，16，12： | 1 |
| 10 | Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases显示文摘 | Cowling B J Jin L Lau E H Y | | The Lancet0，382，9887： | 1 |
| 11 | Ethanolic fermentation of hydroly- sates from ammonia fiber expansion ( AFEX) treated com stover and distillers grain without detoxification and external nutrient supplementation显示文摘 | Lau M W Dale B E Balan V | 2008 | Biotechnology and bioengineering2008，99，3： | 1 |
| 12 | Which Ore field signs/symptoms predict protracted recovery from sport- related concussion among high school football players? 显示文摘 | LAU B C KONTOS A P COLLINS M W | 2011 | Am J Sports Med2011，39，11： | 1 |
| 13 | Twice-Weekly paclitaxel and weekly carboplatin with concurrent thoracic radiation followed by carboplatin/paclitaxel consolidation for stage Ⅲ non-small-cell lung cancer: a California Cancer Consortium phase Ⅱ trial显示文摘 | Lau D Leigh B Gandara D | 2001 | J Clin Oncol2001，19，： | 1 |
| 14 | Spectroscopic Ellipsometry of Metal Phthalocyanine Thin Films 显示文摘 | DjuriSic A B Kwong C Y Lau T W et at | 2003 | Applied Optics2003，42，31： | 1 |
| 15 | Twice - weekly paclitaxel andweekly carboplatin with concurrent thoracic radiation followed bycarboplation/paclitaxel consolidation for stage Id non - small celllung canner: a California Cancer Consortium Phase H Trial 显示文摘 | Lau D Leigh B Gandara D | 2001 | J Clin Oncol2001，19，2： | 1 |
| 16 | Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus(MRSA)and inhibition of MRSA pyruvate kinase显示文摘 | Chan B C Ip M Lau C B | 2011 | J Ethnopharmacol2011，137，1： | 1 |
| 17 | C-reactive protein is a marker for human immunodeficiency virus disease progression 显示文摘 | Lau B Sharrett AR Kingsley LA | 2006 | Arch Intern Med2006，166，1： | 1 |
| 18 | Emergence of enterovirus 71 'double-recombinant' strains belonging to a novel genotype D originating from southern China: first evidence for combination of intratypic and intertypic recombination events in EV71 显示文摘 | Yip C C Lau S K Zhou B | 2010 | Arch Virol2010，9，： | 1 |
| 19 | Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries显示文摘 | Diatchenko L Lau YF Campbell AP Chenchik A Moqadam F Huang B | 1996 | Proc Natl Acad Sci USA1996，93，12： | 1 |
| 20 | Improving equipment purcha- sing decisions through human factors engineering显示文摘 | Lau L Vargo B Gieras I | 2008 | Bi- omed Instrum Technol2008，42，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员