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| 1 | 鞘内注射巴氯芬治疗卒中后痉挛性肌张力增高的专家共识指南显示文摘卒中后痉挛性肌张力增高可导致畸形、不适和运动功能缺损加重,鞘内注射巴氯芬(ITB)已经被越来越多地用于这种并发症的处理。由于它在卒中中的应用不像其他适应证一样得到肯定,因此ITB治疗尚未经过严格的研究。指导临床医生在这类患者中进行ITB治疗的证据非常有限。本文旨在对有关这一主题的现有科学文献和一些专家观点进行评价,同时阐述这些专家针对可能影响卒中人群的常见临床问题治疗决策的推荐意见。 | Gerard E. Francisco Smart A. Yablon Mya C. Schiess Laura Wiggs Steven Cavalier Samuel Grissom 李振光(译) 孙新虎(译) 迟相林(译) 蒋东晓(译) 丛艳斌(译) | 2008 | 国际脑血管病杂志2008，16，3： | 4 |
| 2 | Terahertz pulse imaging in archaeology显示文摘在这份报纸介绍的工作在芝加哥大学在东方研究所被执行,在从他们的永久收集的目标上:一具古老的埃及鸟木乃伊和三个古老的闪族语的侵蚀的铜合金目标。我们使用了便携式的、联合纤维的兆兆赫(THz ) 时间域分光镜的成像系统,它允许我们在传播和思考几何学测量标本,和基于时间、基于频率的现在想象模式。结果证实 THz 成像能提供互补信息给那的更早的证据从计算断层摄影术(XRCT ) 木乃伊扫描的 X 光检查可获得,给低密度区域的更好的可视化。另外,我们证明 THz 成像能在金属人工制品区分使矿物化的层。 | J. Bianca JACKSON Julien LABAUNE Rozenn BAILLEUL-LESUER Laura D'ALESSANDRO Alison WHYTE John W. BOWEN Michel MENU Gerard MOUROU | 2015 | Frontiers of Optoelectronics2015，8，1： | 3 |
| 3 | Bone density of the radius, spine, and hip in relation to percent of ideal body weight in postmenopausal women显示文摘 | Bess Dawson-Hughes M.D. Clanton Shipp Laura Sadowski Gerard Dallal | 1987 | Calcified Tissue International1987，，6： | 2 |
| 4 | Retrospective evaluation of FOLFIRI3 alone or in combination with bevacizumab or aflibercept in metastatic colorectal cancer显示文摘BACKGROUND The treatment of metastatic colorectal cancer(mCRC) relies of chemotherapy. The efficacy of the standard FOLFIRI-therapy could be improved by a modification of the regimen by splitting the dose of irinotecan on day 1 and day 3 in the FOLFIRI3 regimen.AIM To determine safety and efficacy of FOLFIRI3 regimen.METHODS This is a monocentric retrospective study evaluating the efficacy and safety of the FOLFIRI3 regimen given alone or in combination with bevacizumab or aflibercept in patients with previously treated mCRC.RESULTS One hundred and fifty-three consecutive patients were included(18 treated with FOLFIRI3, 99 with FOLFIRI3 plus bevacizumab and 36 with FOLFIRI3 plus aflibercept). The overall response rate(ORR) and disease control rate were 51%and 62%, respectively. Similar ORRs were observed in all 3 cohorts. Median progression-free survival(PFS) and overall survival(OS) were 3.9 mo(95%CI:3.2-4.9) and 9.4 mo(95%CI: 6.6-12), respectively. Median PFS and OS values were improved in the FOLFIRI3 plus aflibercept group. The most common grade 3-4 adverse events were diarrhoea(21.6%) and neutropenia(11.8%), and these toxicities were more frequent in the FOLFIRI3 plus aflibercept group. According to the multivariate Cox proportional model, previous surgery of metastasis andaflibercept were associated with outcomes.CONCLUSION The modification of the FOLFIRI regimen impacted treatment response of mCRC patients. The addition of an antiangiogenic agent, in particular aflibercept,enhanced the clinical benefit and improved survival. | Madeline Devaux Laura Gerard Corentin Richard Leila Bengrine-Lefevre Julie Vincent Antonin Schmitt Fran?ois Ghiringhelli | 2019 | World Journal of Clinical Oncology2019，10，2： | 2 |
| 5 | SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation显示文摘 | Gergana Dobreva Maria Chahrour Marcel Dautzenberg Laura Chirivella Benoit Kanzler Isabel Fari?as Gerard Karsenty Rudolf Grosschedl | 2006 | Cell2006，，5： | 1 |
| 6 | The Effect of Combined Calcium and Vitamin D 3 Supplementation on Serum Intact Parathyroid Hormone in Moderate CKD显示文摘 | Laura Kooienga Linda Fried Robert Scragg Jessica Kendrick Gerard Smits Michel Chonchol | 2009 | American Journal of Kidney Diseases2009，，3： | 1 |
| 7 | Fulminant hepatic failure associated with bicalutamide显示文摘 | Laura A. Dawson Edward Chow Gerard Morton | 1997 | Urology1997，，2： | 1 |
| 8 | Dipeptidyl aminopeptidase IV and aminopeptidase P, two proline specific enzymes from the cytoplasm of guinea pig brain: their role in metabolism of peptides containing consecutive prolines显示文摘 | LAURA G GERARD C | 1999 | Neurosei Res1999，，34： | 1 |
| 9 | The ups and downs of myc biology 显示文摘 | Laura S Gerard I E | 2010 | Curr Opin Genet2010，20，1： | 1 |
| 10 | Interaction of TSH,insulin and insulin-like growth factorsin regulating thyroid growth and function显示文摘 | Margaret C Eggo Laura K Bachrach Gerard N Burrow | 1990 | Growth Fac-tors1990，2，2： | 1 |
| 11 | 老年人群的糖尿病控制:治疗病人,而不是治疗糖化血红蛋白显示文摘医疗服务提供者们必须准备好面对两个人口统计学变化:人们对寿命的预期增加以及我们正在变胖这个事实。各个年龄人群中,包括高龄人群中的糖尿病患病率都在提高。65岁以上的糖尿病患者的微血管和大血管并发症的发病率更高,导致住院率增加、医疗费用和护理费用增加,对社会照顾的需求也增加。治疗老年糖尿病患者是一个挑战,不仅因为低血糖的风险,过于激进的治疗也会导致并发症增加。 | Laura A McLaren Terence J Quinn Gerard A McKay 柳雨(译) 李玉秀(校) | 2013 | 英国医学杂志中文版2013，16，5： | 0 |
| 12 | Global mapping of volumetric water retention at 100,330 and 15000 cm suction using the WoSIS database显示文摘Present global maps of soil water retention(SWR)are mostly derived from pedotransfer functions(PTFs)applied to maps of other basic soil properties.As an alternative,'point-based'mapping of soil water content can improve global soil data availability and quality.We developed point-based global maps with estimated uncertainty of the volumetric SWR at 100,330 and 15000 cm suction using measured SWR data extracted from the WoSIS Soil Profile Database together with data estimated by a random forest PTF(PTF-RF).The point data was combined with around 200 environmental covariates describing vegetation,terrain morphology,climate,geology,and hydrology using DSM.In total,we used 7292,33192 and 42016 SWR point observations at 100,330 and 15000 cm,respectively,and complemented the dataset with 436108 estimated values at each suction.Tenfold cross-validation yielded a Root Mean Square Error(RMSE)of6380,7.112 and 6.48510^(-2)cm^(3)cm^(-3),and a Model Efficiency Coefficient(MEC)of0.430,0386,and 0.471,respectively,for 100,330 and 15000 cm.The results were also compared to three published global maps of SWR to evaluate differences between point-based and map-based mapping approaches.Point-based mapping performed better than the three map-based mapping approaches for 330 and 15000 cm,while for 100 cm results were similar,possibly due to the limited number of SWR observa-tions for 100 cm.Major sources or uncertainty identified included the geographical clustering of the data and the limitation of the covariates to represent the naturally high variation of SWR. | Maria Eliza Turek Laura Poggio Niels H.Batjes Robson Andre Armindo Quirijn de Jong van Lier Luis de Sousa Gerard B.M.Heuvelink | 2023 | International Soil and Water Conservation Research2023，11，2： | 0 |
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