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| 1 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 2 | Quality Improvement Guidelines for the Treatment of Lower Extremity Deep Vein Thrombosis with Use of Endovascular Thrombus Removal显示文摘 | Suresh Vedantham Patricia E. Thorpe John F. Cardella Clement J. Grassi Nilesh H. Patel Hector Ferral Lawrence V. Hofmann Bertrand M. Janne d’Othée Vittorio P. Antonaci Elias N. Brountzos Daniel B. Brown Louis G. Martin Alan H. Matsumoto Steven G. Meranze | 2006 | Journal of Vascular and Interventional Radiology2006，，3： | 3 |
| 3 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 4 | Identification of inertial and friction parameters for excavator arms 显示文摘 | Tafazoli S Lawrence P D Salcudean S E | 1999 | IEEE Transactions on Robotics and Automation1999，15，5： | 1 |
| 5 | The Sunnybrook Stroke Study: A Prospective Study of Depressive Symptoms and Functional Outcome显示文摘 | Herrmann N Black S E Lawrence J | 1998 | Stroke1998，29，3： | 1 |
| 6 | A theory of high-frequency distortion in bipolar transistors显示文摘 | Vaidyanathan Mani Iwamoto Masaya Larson Lawrence E | 2003 | IEEE Trans on Microwave Theory and Techniques2003，51，2： | 1 |
| 7 | Pilot scale study of trace element vaporization and condensation during combustion of a pulverized subbituminous coal显示文摘 | Constance L Lawrence E | 2000 | Fuel Processing Technology2000，，63： | 1 |
| 8 | Disease resistance conferred by expression of a gene encoding H2O2-generating glucose oxidase in transgenic potato plants显示文摘 | WU G SHORTT B J LAWRENCE E B | 1995 | Plant Cell1995，9，： | 1 |
| 9 | Improved endpoint detector for isolated word recognition显示文摘 | Lori F Lamel Lawrence R Rabiner Aaron E Rosenberg | | 0，，04： | 1 |
| 10 | Geohydrologic,geochemical,and geologic controls on the occurrence of radon in groundwater near Conifer,Colorado,USA显示文摘 | Lawrence E Poeter E Wanty R | 1991 | Journal of Hydrology1991，127，14： | 1 |
| 11 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 12 | Liquidity, Trading Rules, and Electronic Trading Systems 显示文摘 | Harris Lawrence E | 1990 | Monograph Series in Finance and Economics1990，，4： | 1 |
| 13 | Disease resistance conferred by expression of a gene encoding H2O2- generating glucose oxidase in transgenic potato plant 显示文摘 | Wu G B J Shortt E B Lawrence | 1995 | The Plant Cell1995，7，： | 1 |
| 14 | Rate effects in uniaxial dynamic compression of concrete显示文摘 | Tang T X Lawrence E Malvern Dacid A Jenkins | 1992 | Journal of Engineering Mechanics1992，118，1： | 1 |
| 15 | Identification of regions in alleles of the flax rust resistance gene L that determine ditierences in gene-for-fene spocificity显示文摘 | ELLIS J G LAWRENCE G J LUCK J E | 1999 | Plant Cell1999，11，： | 1 |
| 16 | The deuterium to hydrogen ratios of sap in trees: implications for water sources and tree ring deuterium to hydrogen ratios显示文摘 | White J W C Cook E R Lawrence J R | 1985 | Geochimica Et Cosmochimiea Aeta1985，49，： | 1 |
| 17 | Spatial analysis of Honolulu motor vehicle crashes: I spatial patterns 显示文摘 | Ned Levine Karl E Kim Lawrence H Nitz | 1996 | Accident Analysis and Prevention1996，27，5： | 1 |
| 18 | Fast accurate fuzzy clustering through data reduction 显示文摘 | Steven E Jing W K Lawrence O | 2003 | IEEE Trans on Fuzzy Systems2003，11，2： | 1 |
| 19 | Time- accurate computational fluid dynamics approach to tran- sonic store separation trajectory prediction显示文摘 | LAWRENCE E LIJEWSKI NORMAN E SUHS | 1994 | Journal of Aircraft1994，31，4： | 1 |
| 20 | Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism显示文摘 | Alexander EK Marqusee E Lawrence J | 2004 | N Engl J Med2004，351，3： | 1 |
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