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| 1 | Effectiveness of Inactivated COVID-19 Vaccines Against Symptomatic,Pneumonia,and Severe Disease Caused by the Delta Variant:Real World Study and Evidence—China,2021显示文摘Summary What is already known about this topic?Effectiveness of China’s 2 inactivated vaccines(BBIBPCorV and CoronaVac)against pre-Delta severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)variants ranged from 47%to over 90%,depending on the clinical endpoint,and with greater effectiveness against more severe coronavirus disease 2019(COVID-19).During an outbreak in Guangdong,inactivated vaccine effectiveness(VE)against the Delta variant was 70%for symptomatic infection and 100%for severe COVID-19.However,separate or combined VE estimates for the two inactivated vaccines against Delta are not available.What is added by this report?In an outbreak that started in a hospital,VEs of completed primary vaccination with inactivated COVID-19 vaccines against symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant were 51%,61%,and 82%.Completed primary vaccination reduced the risk of progressing from mild to moderate or severe COVID-19 by 74%.VE estimates for BBIBP-CorV and CoronaVac or combined vaccination were similar,and partial vaccination was ineffective.What are the implications for public health practice?Completed primary vaccination with either of the 2 inactivated COVID-19 vaccines reduces risk of symptomatic COVID-19,COVID-19 pneumonia,and severe COVID-19 caused by the Delta variant.Completion of the completed primary vaccination with two doses is necessary for protection from Delta. | Dan Wu Yanyang Zhang Lin Tang Fuzhen Wang Ying Ye Chao Ma Hui Zheng Wenzhou Yu Lei Cao Yifan Song Abuduwaili Reyimu Xiaoxiao Zhang Haifeng Wang Yifei Nie Mingxia Lu Muge Qi Jun Li Ruolin Wang Kaichao Yang Changshuang Wang Lawrence Everett Rodewald Geroge Fu Gao Zhijie An Zundong Yin | 2022 | China CDC weekly2022，4，4： | 7 |
| 2 | Current and future molecular diagnostics in colorectal cancer and colorectal adenoma显示文摘Colorectal cancer(CRC)is one of the most prevalent cancers in developed countries.On the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy.Since CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the disease.Fecal occult blood test is a widely used non-invasive screening tool for CRC.Although fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the test.Genetic dysregulations have been found to play an important role in CRC development.With better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC.In this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were discussed.This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma. | Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 3 | Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer显示文摘 | Brian M. Wolpin Ying Bao Zhi Rong Qian Chen Wu Peter Kraft Shuji Ogino Meir J. Stampfer Kaori Sato Jing Ma Julie E. Buring Howard D. Sesso I-Min Lee John Michael Gaziano Anne McTiernan Lawrence S. Phillips Barbara B. Cochrane Michael N. Pollak JoAnn E. Ma | 2013 | JNCI Journal of the National Cancer Institute2013，，14： | 2 |
| 4 | Morphology and orientation evolution of Cu_(6)Sn_(5)grains on(001)Cu and(011)Cu single crystal substrates under temperature gradient显示文摘The morphology and orientation evolution of Cu_(6)Sn_(5)grains formed on(001)Cu and(011)Cu single crystal substrates under temperature gradient(TG)were investigated.The initial orientated prism-type Cu_(6)Sn_(5)grains transformed to non-orientated scallop-type after isothermal reflow.However,the Cu_(6)Sn_(5)grains with strong texture were revealed on cold end single crystal Cu substrates by imposing TG.The Cu_(6)Sn_(5)grains on(001)Cu grew along their c-axis parallel to the substrate and finally merged into one grain to form a fully IMC joint,while those on(011)Cu presented a strong texture and merged into a few dominant Cu_(6)Sn_(5)grains showing about 30°angle with the substrate.The merging between neighboring Cu_(6)Sn_(5)grain pair was attributed to the rapid grain growth and grain boundary migration.Accordingly,a model was put forward to describe the merging process.The different morphology and orientation evolutions of the Cu_(6)Sn_(5)grains on single crystal and polycrystal Cu substrates were revealed based on crystallographic relationship and Cu flux.The method for controlling the morphology and orientation of Cu_(6)Sn_(5)grains is really benefitial to solve the reliability problems caused by anisotropy in 3 D packaging. | Yuanyuan Qiao Xiaoying Liu Ning Zhao Lawrence C M Wu Chunying Liu Haitao Ma | 2021 | Journal of Materials Science & Technology2021，，36： | 2 |
| 5 | Initial genome sequencing and analysis of multiple myeloma 显示文摘 | Chapman MA Lawrence MS Keats JJ | 2011 | Nature2011，471，7339： | 1 |
| 6 | Initial genome sequencing and analysis of multiple myeloma显示文摘 | Chapman MA Lawrence MS Keats J J | 2011 | Nature2011，471，7339： | 1 |
| 7 | Rearrangement of ALL1(MLL)in acute myeloid leukemia with normal cytogenetics显示文摘 | Caligiuri MA Strout MP Lawrence D | 1998 | Cancer Res1998，58，1： | 1 |
| 8 | Stereoselec- tive absorption and hydrolysis of cefuroxime axetil diastereomers using the Caco-2 cell monolayer model显示文摘 | BARRETr MA LAWRENCE M J HUTY AJ | 1997 | Eur J Drug Metab Pharmacokine1997，22，4： | 1 |
| 9 | Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer显示文摘 | Brian M. Wolpin Ying Bao Zhi Rong Qian Chen Wu Peter Kraft Shuji Ogino Meir J. Stampfer Kaori Sato Jing Ma Julie E. Buring Howard D. Sesso I-Min Lee John Michael Gaziano Anne McTiernan Lawrence S. Phillips Barbara B. Cochrane Michael N. Pollak JoAnn E. Ma | 2013 | JNCI Journal of the National Cancer Institute2013，，14： | 1 |
| 10 | Heteroduplex molecules formed between allelic sequences cause nonparental RAPD bands显示文摘 | Ayliffe MA Lawrence GJ Ellis JG | 1994 | Nucleic Acid Research1994，22，9： | 1 |
| 11 | Fluorescent stai ning of kappa opioid receptors using naltrexamine derivativesand phycoerythrin显示文摘 | Lawrence DM Hutchinson I Seyed MA etal | 1997 | J Immunol Methods1997，201，2： | 1 |
| 12 | Radiotherapy: What can be achieved by technical improvements in dose delivery显示文摘 | Moran JM Elshaikh MA Lawrence TS | 2005 | The Lancet Oneology2005，6，1： | 1 |
| 13 | Silk film biomaterials for cornea tissue engineering 显示文摘 | Lawrence BD Marchant JK Pindrus MA | 2009 | Biomaterials2009，30，7： | 1 |
| 14 | The role of apoptosis in 2 , 2 difluoro-2 deoxycytidine ( gemcitabine ) -mediated radiosensltization显示文摘 | Lawrence TS Davis MA Hough A | 2001 | Clin Cancer Res2001，7，2： | 1 |
| 15 | Radiotherapy: what can be achieved by technical improvements in dose delivery? 显示文摘 | Moran JM Elshaikh MA Lawrence TS | 2005 | Lancet Oncol2005，6，1： | 1 |
| 16 | Rearrangement of ALL1(MLL) in acute myeloid leukemia with normal显示文摘 | Caligiuri MA Strout MP Lawrence D | 1998 | Cancer Res1998，58，1： | 1 |
| 17 | A network biology approach to prostate cancer 显示文摘 | Ergun A Lawrence CA Kohanski MA | 2007 | Mol Syst Biol2007，3，： | 1 |
| 18 | Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study显示文摘 | Catharina C Boehme Mark P Nicol Pamela Nabeta Joy S Michael Eduardo Gotuzzo Rasim Tahirli Ma Tarcela Gler Robert Blakemore William Worodria Christen Gray Laurence Huang Tatiana Caceres Rafail Mehdiyev Lawrence Raymond Andrew Whitelaw Kalaiselvan Sagadevan | 2011 | The Lancet2011，，9776： | 1 |
| 19 | Initial genome sequencing and analysis of multiple myeloma显示文摘 | Chapman MA Lawrence MS Keats JJ | | 0，，7339： | 1 |
| 20 | Initial genome se quencing and analysis of multiple myeloma显示文摘 | Chapman MA Lawrence MS Keats J J | | 0，，7339： | 1 |
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