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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Earth observation in service of the 2030 Agenda for Sustainable Development显示文摘This paper reviews the key role that Earth Observations(EO)play in achieving the Sustainable Development Goals(SDGs)as articulated in the 2030 Agenda document and in monitoring,measuring,and reporting on progress towards the associated targets.This paper also highlights how the Group on Earth Observations(GEO)would contribute to ensure the actual use of EO in support of the 2030 Agenda;and how the Global Earth Observations System of Systems meets requirements for efficient investments in science and technology and a good return on investment,which is elaborated in the Addis Ababa Action Agenda on development financing.Through a number of examples,we first discuss how extensive EO use would:provide a substantial contribution to the achievements of the SDGs by enabling informed decision-making and by allowing monitoring of the expected results;improve national statistics for greater accuracy,by ensuring that the data are“spatially-explicit”and directly contribute to calculate the agreed SDG Targets and Indicators support the fostering of synergy between the SDGs and multilateral environmental agreements by addressing cross-cutting themes such as climate and energy;and facilitate countries’approaches for working across different development sectors,which is,according to the special adviser on the 2030 Agenda,a key challenge to achieve the SDGs.We then focus on the role that GEO could play in enabling actual use of EO in support of the 2030 Agenda by directly addressing the Strategic Development Goal 17 on partnerships. | Katherine Anderson Barbara Ryan William Sonntag Argyro Kavvada Lawrence Friedl | 2017 | Geo-Spatial Information Science2017，20，2： | 8 |
| 3 | Next-Generation Stool DNA Test Accurately Detects Colorectal Cancer and Large Adenomas显示文摘 | David A. Ahlquist Hongzhi Zou Michael Domanico Douglas W. Mahoney Tracy C. Yab William R. Taylor Malinda L. Butz Stephen N. Thibodeau Linda Rabeneck Lawrence F. Paszat Kenneth W. Kinzler Bert Vogelstein Niels Chr. Bjerregaard S?ren Laurberg Henrik Toft S? | 2012 | Gastroenterology2012，，2： | 7 |
| 4 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 5 | A multi‐institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer显示文摘 | Edward J. Kim Edgar Ben‐Josef Joseph M. Herman Tanios Bekaii‐Saab Laura A. Dawson Kent A. Griffith Isaac R. Francis Joel K. Greenson Diane M. Simeone Theodore S. Lawrence Daniel Laheru Christopher L. Wolfgang Terence Williams Mark Bloomston Malcolm J. Moo | 2013 | Cancer2013，，15： | 3 |
| 6 | Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial显示文摘 | William T Cefalu Lawrence A Leiter Kun-Ho Yoon Pablo Arias Leo Niskanen John Xie Dainius A Balis William Canovatchel Gary Meininger | 2013 | The Lancet2013，，： | 3 |
| 7 | Returns to scale in different DEA models显示文摘 | Rajiv D. Banker William W. Cooper Lawrence M. Seiford Robert M. Thrall Joe Zhu | 2003 | European Journal of Operational Research2003，，2： | 2 |
| 8 | Volumetric Analysis Predicts Hepatic Dysfunction in Patients Undergoing Major Liver Resection显示文摘 | Margo Shoup Mithat Gonen Michael D’Angelica William R Jarnagin Ronald P DeMatteo Lawrence H Schwartz Scott Tuorto Leslie H Blumgart Yuman Fong | 2003 | Journal of Gastrointestinal Surgery2003，，3： | 2 |
| 9 | Kidney Damage and Renal Functional Changes are Minimized by Waveform Control that Suppresses Cavitation in Shock Wave Lithotripsy显示文摘 | Andrew P. Evan Lynn R. Willis James A. McAteer Michael R. Bailey Bret A. Connors Youzhi Shao James E. Lingeman James C. Williams Naomi S. Fineberg Lawrence A. Crum | 2002 | The Journal of Urology2002，，4： | 2 |
| 10 | Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis显示文摘 | William R Kessler Oscar W Cummings George Eckert Naga Chalasani Lawrence Lumeng Paul Y Kwo | 2004 | Clinical Gastroenterology and Hepatology2004，，7： | 2 |
| 11 | 美国佛罗里达州阿波普卡湖水文和土地利用变化的生物突变响应显示文摘阿波普卡(Apopka)湖位于佛罗里达中北部,是一个富营养化的浅水湖泊。1947年,湖泊的初级生产群落结构(PPCS)发生了巨大的变化。在1947年,水下的水生植物被飓风连根拔起,并在数周之内被浮游植物所替代,初级生产群落结构发生了突然演替。在此我们提出两个假设解释群落结构向浮游植物的突然演替。首先,流域在19世纪初后期的水文变化使湖泊的水位大约下降了1.0m,从而使生态系统通过大型植物群落生产力提高适应了中等的、人为的营养物质富集的环境。第二,开始于1942年的泛滥平原湿地的水文变化和大规模的农业发展,改变了湖泊中磷载荷的模式和规模,引起了1947年浮游植物占优势的突然变化。历史上土地利用变化和古湖泊在营养物的生物响应数据方面也支持这些假设。 | Claire L.Schelske Edgar F.Lowe Lawrence E.Battoe Mark Brenner Michael F.Coveney William F.Kenney 刘相超 | 2005 | AMBIO-人类环境杂志2005，34，3： | 2 |
| 12 | Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection显示文摘 | Margo Shoup M.D. Mitbat Gonen Ph.D. Michael D'Angelica M.D. William R. Farnagin M.D. Ronald P. DeMatteo M.D. Lawrence H. Schwartz M.D. Scott Tuorto Leslie H. Blumgart M.D. Yuman Fong M.D | 2003 | Journal of Gastrointestinal Surgery2003，，3： | 2 |
| 13 | Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen‐positive hepatocellular carcinoma: a comparison with chronic carriers显示文摘 | Myron J.Tong Lawrence M.Blatt Jia‐HorngKao Jason TzuyingCheng William G.Corey | 2007 | Liver International2007，，10： | 2 |
| 14 | Comparison of magnetic resonance and endoscopic retrograde cholangiopancreatography in malignant pancreaficobiliary obstruction显示文摘 | STEVE K LAWRENCE H WILLIAM R el al | 1999 | Arch Surg1999，134，： | 1 |
| 15 | Intrahepatic Cholangiocarcinoma: Rising Frequency, Improved Survival, and Determinants of Outcome After Resection显示文摘 | Itaru Endo Mithat Gonen Adam C. Yopp Kimberly M. Dalal Qin Zhou David Klimstra Michael D?Angelica Ronald P. DeMatteo Yuman Fong Lawrence Schwartz Nancy Kemeny Eileen O?Reilly Ghassan K. Abou-Alfa Hiroshi Shimada Leslie H. Blumgart William R. Jarnagin | 2008 | Annals of Surgery2008，，1： | 1 |
| 16 | Subcortieal and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression 显示文摘 | Lawrence NS Williams AM Surguladze S | 2004 | Biol Psychiatry2004，15，4： | 1 |
| 17 | Subcortical and Ventral prefrontal cortical neural responses to facial expression distinguish patients with bipolar disorder and major depression显示文摘 | Lawrence NS Williams AM Surguladze S | 2004 | Biol Psychiatry2004，55，： | 1 |
| 18 | Design, implementation, and evaluation of an innovative anatomy course显示文摘 | Lawrence J.Rizzolo William C.Rando Michael K.O’Brien Andrew H.Haims James J.Abrahams William B.Stewart | 2010 | Anat Sci Ed2010，，3： | 1 |
| 19 | External Fixation of Tibial Plafond Fractures: Is Routine Plating of the Fibula Necessary?显示文摘 | Todd M. Williams J. Lawrence Marsh James V. Nepola Thomas A. DeCoster Shepard R. Hurwitz Susan B. Bonar | 1998 | Journal of Orthopaedic Trauma1998，，1： | 1 |
| 20 | Synthetic Vision Enhanced Surface Operations With Head-Worn Display for Commercial Aircraft显示文摘 | Jarvis J. Arthur Lawrence J. Prinzel Kevin J. Shelton Lynda J. Kramer Steven P. Williams Randall E. Bailey Robert M. Norman | 2009 | The International Journal of Aviation Psychology2009，，2： | 1 |
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