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| 1 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 2 | GENETIC PROGRAMMING TO PREDICT SKI-JUMP BUCKET SPILLWAY SCOUR显示文摘Researchers in the past had noticed that application of Artificial Neural Networks (ANN) in place of conventional statistics on the basis of data mining techniques predicts more accurate results in hydraulic predictions. Mostly these works pertained to applications of ANN. Recently, another tool of soft computing, namely, Genetic Programming (GP) has caught the attention of researchers in civil engineering computing. This article examines the usefulness of the GP based approach to predict the relative scour depth downstream of a common type of ski-jump bucket spillway. Actual field measurements were used to develop the GP model. The GP based estimations were found to be equally and more accurate than the ANN based ones, especially, when the underlying cause-effect relationship became more uncertain to model. | AZAMATHULLA H. MD GHANI A. AB ZAKARIA N. A LAI S. H CHANG C. K LEOW C. S ABUHASAN Z | 2008 | Journal of Hydrodynamics2008，20，4： | 4 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | Mathematical modelling of elliptic helicoid screw transmission systems显示文摘 | Wu D S Lai H Y Chen C K | 2002 | Proceedings of the Institution of Mechanical Engineers Part B: Journal of Engineering Manufacture2002，216，2： | 1 |
| 5 | Using single family in reforestation: gene diversity concerns 显示文摘 | Kang K S Lai H L Lindgren D | 2002 | Silvae Genetica2002，51，23： | 1 |
| 6 | Model- ling visual attention via selective tuning显示文摘 | J K Tsotsos S M Culhane Y H Lai | 1995 | Artificial Intelligence1995，78，1： | 1 |
| 7 | A cointegration test for market efficiency 显示文摘 | Lai K S Lai M | 1991 | Joumal of Futures Markets1991，11，5： | 1 |
| 8 | A partition approach to inventory routing problem显示文摘 | Zhao Q H Wang S Y Lai K K | 2007 | European Journal of Operational Research2007，177，2： | 1 |
| 9 | Intrinsic and extrinsic motivation in Internet use 显示文摘 | Teo S H Lim K G Lai Y C | 1999 | The International Journal of Management Science1999，27，： | 1 |
| 10 | Intrinsic and extrinsic motivation in Internet usage显示文摘 | Teo T S H Lim V K G Lai R Y C | 1999 | Omega1999，27，1： | 1 |
| 11 | Carbene and isocya- nide ligation at luminescent eyclometalated 6-phenyl-2,2-bipyr- idyl platinum ( Ⅱ ) complexesStruetural and spectroseopic显示文摘 | Lai S W Chan M C W Cheung K K | 1999 | Organometallics1999，18，17： | 1 |
| 12 | Some physicochemical properties of Moringa oleifera seed oil extracted using solvent and aqueous enzymatic methods 显示文摘 | Abdulkarim S M Long K Lai O M | 2005 | Food Chemistry2005，93，1： | 1 |
| 13 | Manufacturer's revenuesharing contract and retail competition显示文摘 | YAO Z LEVNG S H LAI K K | 2008 | European Journal of Operational Research2008，186，2： | 1 |
| 14 | A fixed-frequency pulsewidth modulation based quasi-sliding-mode controller for Buck converters显示文摘 | TAN S C LAI Y M TSE C K | 2005 | IEEE Transactions on Power Electronics2005，20，6： | 1 |
| 15 | A PWM method for reduction of switching loss in an full-bridge Inverter显示文摘 | LAI R S NGO K D T | 1995 | IEEE Trans on PE1995，10，3： | 1 |
| 16 | Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release显示文摘 | Choi K S Aizaki H Lai M M | 2005 | J Virol2005，79，15： | 1 |
| 17 | The effect of chemical treatment on reinforcement/matrix interaction in Kevlar-fiber/bismaleimide composites显示文摘 | Lin T K Wu S J Lai J G | 2000 | Composites Science and Technology2000，，： | 1 |
| 18 | The formation and characterization of palladium nanowire in growing carbon nanotubes using microwave plasma-enhanced chemical vapor deposition显示文摘 | CHAN L H HONG K H LAI S H | 2003 | Thin Solid Films2003，423，： | 1 |
| 19 | Identification of linear time varying systems by Haar wavelet 显示文摘 | Chen S L Lai H C Ho K C | 2006 | Interna tional Journal of System Science2006，37，： | 1 |
| 20 | Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system显示文摘 | Lai K N Tang S C Guh J Y | 2003 | J Am Soc N ephrol2003，14，12： | 1 |
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