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| 1 | Association between orofacial granulomatosis and Crohn's disease in children:Systematic review显示文摘AIM:To review pediatric cases of orofacial granulomatosis(OFG),report disease characteristics,and explore the association between OFG and Crohn’s disease.METHODS:We conducted a systematic review according to the PRISMA guidelines.We searched Medline,LILACS,Virtual Health Library,and Web of Knowledge in September 2013 for cases of OFG in the pediatric age range(<18 years),with no language limitations.All relevant articles were accessed in full text.The manual search included references of retrieved articles.We extracted data on patients’characteristics,disease characteristics,association with other diseases,and treatment.We analyzed the data and reported the results in tables and text.RESULTS:We retrieved 173 reports of OFG in children.Mean age at onset was 11.1±3.8 years(range:2.0-18years).Prevalence in males was significant higher than in females(P<0.001),with a male:female ratio of 2:1.Gastrointestinal signs or symptoms were present in 26.0%of children at the time of OFG diagnosis.Overall,70/173(40.4%)children received a concomitant diagnosis of Crohn’s disease.In about half(51.4%)of the cases the onset of OFG anticipated the diagnosis of Crohn’s disease,with a mean time between the two diagnoses of 13.1±11.6 mo(range:3-36 mo).Overall,21/173(12.1%)of the children with OFG had perianal disease,while 11/173(6.4%)had a family history of Crohn’s disease.Both perianal disease and a family history of Crohn’s disease were significantly associated with a higher risk of Crohn’s disease diagnosis in children with OFG[relative risk(RR)=3.10,95%confidence interval(CI):2.46-3.90;RR=2.74,95%CI:2.24-3.36,P<0.0001 for both).Treatment of OFG included steroids(70.8%of children)and other immunosuppressive drugs(42.7%),such as azathioprine,thalidomide and infliximab.CONCLUSION:High prevalence of Crohn’s disease in children with OFG suggests that OFG may be a subtype of Crohn’s disease. | Marzia Lazzerini Matteo Bramuzzo Alessro Ventura | 2014 | World Journal of Gastroenterology2014，20，23： | 2 |
| 2 | Hyperhomo- cysteniemia, inflammation and autnimmunity 显示文摘 | LAZZERINI P E CAPECCHI P L SELVI E | 2007 | Autoimmun Rev2007，6，7： | 1 |
| 3 | Time dependence and freezing-in of the electrode oxygen plasma-in- duced work function enhancement in polymer semiconductor hetero-structures 显示文摘 | BROWN T M LAZZERINI G M PARROT L J | 2011 | Electron2011，12，4： | 1 |
| 4 | Hyperhomocysteinemia:a cardiovascular risk factor in autoimmune diseases显示文摘 | Lazzerini PE Capecchi PL Selvi E | 2007 | Lupus2007，16，： | 1 |
| 5 | Hy- perhomocysteinemia, in- flammation and auto- immunity 显示文摘 | Lazzerini PE Capecchi PL Selvi E | 2007 | Autoimmun Rev2007，6，： | 1 |
| 6 | Surgically induced astigmatism after manual extracapsular cataract extraction or after phacoemulsification procedure 显示文摘 | Cavallini GM Liugli L Lazzerini A | 1996 | Eur J Ophthalmol1996，6，3： | 1 |
| 7 | Statins as a new therapeutic perspective in myocarditis and postmyocarditis dilated cardiomyopathy 显示文摘 | Lazzerini PE Capecchi PL Laghi-Pasini F | 2013 | Cardiovasc Drugs Ther2013，27，5： | 1 |
| 8 | Connective tissue diseases andcardiac rhythm disordere ; an overview 显示文摘 | Lazzerini PE Capecchi PL Guideri F | 2006 | Autoimmun Rev2006，5，5： | 1 |
| 9 | Hyperhomoeys- teinemia,inflammation and autoimmunity显示文摘 | Lazzerini PE Capeeehi PL Selvi E | 2007 | Autoim- munity Reviews2007，6，7： | 1 |
| 10 | Association between high sensitivity C-reactive protein, heart rate variability and corrected QT interval in patients with chronic infla minatory arthritis 显示文摘 | Lazzerini PE Acampa M Capecchi PL | 2013 | Eur J Intern Med2013，24，4： | 1 |
| 11 | A neuro-fuzzy approch to hybrid intelligent control显示文摘 | Beatrice Lazzerini Leonardo M Marcello Chiaberge | 1999 | IEEE Trans on Industry Applications1999，35，2： | 1 |
| 12 | Short- term prevention of thromboembolic complications in patients with atrial fibrillation with aspirin plus clopidogrel: the Clopidogrel-Aspirin Atrial Fibrillation (CLAAF) pilot study显示文摘 | Lorenzoni R Lazzerini G Cocci F | 2004 | Am Heart J2004，148，1： | 1 |
| 13 | Compari- son of frequency of complex ventricular arrhythmias in pa- tients with positive versus negative anti-Ro/SSA and con- nective tissue disease 显示文摘 | Lazzerini P E Capecchi P L Guideri F | 2007 | Am J Cardiol2007，100，6： | 1 |
| 14 | A Genetic Algorithm for Generating Optimal Assembly Hans显示文摘 | Lazzerini B Marcelloni F | 2000 | Artificial Intelligence in Engineering2000，14，： | 1 |
| 15 | At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesive molecule-1 induction by advanced glycation end products 显示文摘 | Basta G Lazzerini G Del Turco S | 2005 | Arterioscler Thromb Vase Biol2005，25，： | 1 |
| 16 | At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products显示文摘 | Basta G Lazzerini G Del Turco S | 2005 | Arterioscler Thromb Vasc Biol2005，25，7： | 1 |
| 17 | Homocysteine en- hances cytokine production in cultured synoviocytes from rheumatoid arthritis patients 显示文摘 | Lazzerini PE Selvi E Lorenzini S | 2006 | Clinical and Experimental Rheumatology2006，24，： | 1 |
| 18 | Hyperhomocysteinemia : a cardiovascular risk fac- tor in autoimmune diseases 显示文摘 | Lazzerini PE | 2007 | Lupus2007，16，： | 1 |
| 19 | A genetic algorithm for generating optimal assembly plans显示文摘 | LAZZERINI B MARCELLONI F | 2000 | Artificial Intelligence in Engineering2000，14，1： | 1 |
| 20 | A genetic algorithm for generating optimal assembly plans显示文摘 | Lazzerini B Marcelloni F | | 0，，04： | 1 |
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