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| 1 | Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharide-induced acute liver injury in mice显示文摘Objective: To investigated the protective potential of ethanol extracts of Scutellaria baicalensis(S. baicalensis) against lipopolysaccharide(LPS)-induced liver injury. Methods: Dried roots of S. baicalensis were extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS(5 mg/kg of body weight, intraperitoneal injection). Both protein and m RNA levels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. C yclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB protein levels in liver tissues were analyzed by western blotting. Results: Liver injury induced by LPS signifi cantly increased necrosis factor alpha, interleukin-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB in liver tissues. Treatment with ethanol extracts of S. baicalensis prevented all of these observed changes associated with LPS-induced injury in liver mice.Conclusions: Our study showed that S. baicalensis is potentially protective against LPS-induced liver injury in mice. | Hai Nguyen Thanh Hue Pham Thi Minh Tuan Anh Le Huong Duong Thi Ly Tung Nguyen Huu Loi Vu Duc Thu Dang Kim Tung Bui Thanh | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，9： | 3 |
| 2 | Measuring the contact angles of liquid droplets on wool fibers and determining surfaeé energy components显示文摘 | Le C V Ly N G | 1996 | Textile Res J1996，66，6： | 1 |
| 3 | Physical activity over the life course and its association with cognitive performance and impairment in old age显示文摘 | Middleton LE Barnes DE Lui LY Yaffe K | | 0，，： | 1 |
| 4 | Diagnostic accuracy of HMGB-1,sTREM-1,and CD64 as markers of sepsis in patients recently admitted to the emergency department显示文摘 | Gámez-Díaz LY Enriquez LE Matute JD | 2011 | Acad Emerg Med2011，18，8： | 1 |
| 5 | Diagnostic accuracy of HMGB-1, sTREM-1, and CD64 as markers of sepsis in patients recently admitted to the emergency department 显示文摘 | G mez-Di az LY Enriquez LE Matute JD | 2011 | Acad Emerg Med2011，18，8： | 1 |
| 6 | Production and targeting of the Brucella abortus antigen L7/L12 in Lactococcus lactis: a first step towards food-grad live vaccines against Brucellosis 显示文摘 | Ribeiro LA Azevedo V Le LY | 2002 | Appl Environ Microbiol2002，68，2： | 1 |
| 7 | Diagnostic accuracy of HMGB-1, sTREM-1, and CD64 as markers of sepsis in patients recently admitted to the emergency department 显示文摘 | Gomez-Diaz LY Enriquez LE Matute JD | 2011 | Acad Emerg Med2011，18，8： | 1 |
| 8 | Physical activity over the life course and its association with cognitive perfor- mance and impairment in old age显示文摘 | Middleton LE Barnes DE Lui LY | 2010 | J Am Geriatr Soc2010，58，7： | 1 |
| 9 | production and targeting of the Brucella abortus antigen L7/L12 in Lactococcus lactis:a first step towards food-grade live vaccines agaist Brucellosis显示文摘 | Riberio LA Azevedo V Le LY etal | 2002 | Appl Environ Microbiol2002，68，2： | 1 |
| 10 | 1 Calcitril blunts proat hero sclerotic parameters through NF kappa B and p38 in vitro显示文摘 | Ta LY Go LE Benc HS | 2008 | Eur J Clin Invest2008，38，8： | 1 |
| 11 | AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function显示文摘 | Dugan Laura L You Young-Hyun Ali Sameh S Diamond-Stanic Maggie Miyamoto Satoshi DeCleves Anne-Emilie Andreyev Aleksander Quach Tammy Ly San Shekhtman Grigory Nguyen William Chepetan Andre Le Thuy P Wang Lin Xu Ming Paik Kacie P Fogo Agnes | 2013 | Journal of Clinical Investigation2013，，11： | 1 |
| 12 | Isolation and detection of Campylobacter jejuni from chicken fecal samples by immunomagnetic separation- PCR 显示文摘 | Le Ly Thuy Tram Cuong Cao Jonas H~gberg | 2012 | Food control2012，24，12： | 1 |
| 13 | A review of the role of glial cells in understanding retinal disease显示文摘 | Fletcher EL Downie LE Ly A | | 0，，： | 1 |
| 14 | Measuring the Contract Angles of Liquid Droplets on Wool Fibers and Determining Surface Engergy Components 显示文摘 | Le CV Ly N G Stevens M G | 1996 | Textile Research J1996，66，6： | 1 |
| 15 | Alteration of fatty acid metabolism in the liver, adipose tissue, and testis of male mice conceived through assisted reproductive technologies: fatty acid metabolism in ART mice显示文摘 | Wang LY Le F Wang N | 2013 | Lipids Health Dis2013，12，1： | 1 |
| 16 | Measuring the Contract Angles of Liquid Droplets on Wool Fibers and Determining Surface Energy Components 显示文摘 | Le C V Ly N G Stevens M G | 1996 | Textile Research J1996，66，6： | 1 |
| 17 | Physical activity over the life course and its association with cognitive performance and impairment in old age显示文摘 | Middleton LE Barnes DE Lui LY | 2010 | J Am Geriatr Soc2010，58，7： | 1 |
| 18 | Measuring the contact angles of liquid droplets on wool fibers and determining surface energy components 显示文摘 | Le C Ly N Stevens M | 1996 | Text Res J1996，66，6： | 1 |
| 19 | Statistical aspects of best estimate method-- I显示文摘 | ATTILA G MIHA'LY M LE'NA'RD P | 2003 | Reliability Engineering and System Safety2003，80，3： | 1 |
| 20 | Physical activity over the life course and its association with cognitive performance and impairment in old age显示文摘 | Middleton LE Bames DE Lui LY | | 0，，： | 1 |
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