|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An Investigation of Oxidative DNA Damage in Pharmacy Technicians Exposed to Antineoplastic Drugs in Two Chinese Hospitals Using The Urinary 8-OHdG Assay显示文摘Objective To investigate oxidative DNA damage in pharmacy technicians preparing antineoplastic drugs at the PIVAS (Pharmacy Intravenous Admixture Service) in two Chinese hospitals.Methods Urinary 8-OHdG served as a biomarker.5-Fluorouracil (5-FU) concentrations in air,masks and gloves were determined.The spill exposure of each PIVAS technician to antineoplastic drugs was investigated.Eighty subjects were divided into exposed group I,II,and control group I,II.Results 5-FU concentration ratios for gloves and masks in exposed group I were significantly higher than those in exposed group II (P<0.05 or P<0.01).The average urinary 8-OHdG concentrations in exposed group I,control group I,exposed group II,and control group II were 14.69±0.93,10.68±1.07,10.57±0.55,and 11.96±0.73 ng/mg Cr,respectively.Urinary 8-OHdG concentration in exposed group I was significantly higher than that in control group I or that in exposed group II (P<0.01).There was a significant correlation between urinary 8-OHdG concentrations and spill frequencies per technician (P<0.01).Conclusion There was detectable oxidative DNA damage in PIVAS technicians exposed to antineoplastic drugs.This oxidative DNA damage may be associated with their spill exposure experience and contamination of their personal protective equipment. | HUANG Yu Wen JIAN Le ZHANG Mei Bian ZHOU Quan YAN Xiao Feng HUA Xu Dong ZHOU Ying HE Ji Liang | 2012 | Biomedical and Environmental Sciences2012，25，1： | 30 |
| 2 | SbHKT1;4, a member of the high‐affinity potassium transporter gene family from Sorghum bicolor, functions to maintain optimal Na^+/K^+ balance under Na^+ stress显示文摘In halophytic plants, the high‐affinity potassium transporter HKT gene family can selectively uptake Kt in the presence of toxic concentrations of Nat. This has so far not been well examined in glycophytic crops. Here, we report the characterization of SbHKT1;4, a member of the HKT gene family from Sorghum bicolor. Upon Nat stress, SbHKT1;4 expression was more strongly upregulated in salt‐tolerant sorghum accession, correlating with a better balanced Nat/ Kt ratio and enhanced plant growth. Heterogeneous expression analyses in mutants of Saccharomyces cerevisiae and Arabidopsis thaliana indicated that overexpressing SbHKT1;4 resulted in hypersensitivity to Nat stress, and such hypersensitivity could be alleviated with the supply of elevated levels of Kt, implicating that SbHKT1;4 may mediate Kt uptake in the presence of excessive Nat. Further electrophysiological evidence demonstrated that SbHKT1;4 could transport Nat and Kt when expressed in Xenopus laevis oocytes. The relevance of the finding that SbHKT1;4 functions to maintain optimal Nat/Kt balance under Nat stress to the breeding of salt‐tolerant glycophytic crops is discussed. | Tian‐Tian Wang Zhi‐Jie Ren Zhi‐Quan Liu Xue Feng Rui‐Qi Guo Bao‐Guo Li Le‐Gong Li Hai‐Chun Jing | 2014 | Journal of Integrative Plant Biology2014，56，3： | 11 |
| 3 | First Oligocene mummified plant Lagerst?tte at the low latitudes of East Asia显示文摘Mummified fossils are extraordinarily important for understanding both biotic evolution and ecology in the geological time,by uniquely providing a far more detailed source of information in comparison to impression materials.However,mummified fossils are extremely rare because of the inevitable requirement of unusual preservation conditions during fossilization,including the lithological features and deposition rate of surrounding rocks,and moisture and temperature conditions(Taylor et al.,2009).To date,only a few Cenozoic sites have been reported to yield mummified plant fossils around the world,such as the middle | QUAN Cheng FU Qiong Yao SHI Gong Le LIU Yu Sheng LI Long LIU Xiao Yan JIN Jian Hua | 2016 | Science China Earth Sciences2016，59，3： | 4 |
| 4 | It Takes Two to Tango: Entrepreneurship and Creativity in Troubled Times--Vietnam 2012显示文摘 | Nancy K. Napier Dang Le Nguyen Vu Quan Hoang Vuong | 2012 | Journal of Sociology Study2012，2，9： | 2 |
| 5 | Two new terpenes from Tripterygium wilfordii显示文摘Two new terpenes,wilfornine H(1) and triptobenzene Q(2) were isolated from Tripterygium wilfordii,as well as 11 terpenes. Their structures were elucidated by spectroscopic methods.Compounds 5,9-13 showed significant immunosuppressive activities. | Bo Le Li Qian Shen Mei Na Jin Hong Quan Duan | 2010 | Chinese Chemical Letters2010，21，7： | 2 |
| 6 | Involement of C - Abl tyrosine kinase in lipopolysaccharide- induced macrophage activation 显示文摘 | Le Quan Daniel R Chung S W | 1998 | J Immunnol1998，160，： | 2 |
| 7 | Hepatoprotective effect of majonoside R2,the majorsaponin from vietnamese ginseng 显示文摘 | Quan le Tran | 2002 | Plsnta Med2002，68，： | 1 |
| 8 | Global Burden of Cardiovascular Disease Attributable to High Temperature in 204 Countries and Territories from 1990 to 2019显示文摘Objective This study aimed to estimate spatiotemporal variations of global heat-related cardiovascular disease(CVD)burden from 1990 to 2019.Methods Data on the burden of heat-related CVD were derived from the Global Burden of Disease Study 2019.Deaths and disability-adjusted life years(DALYs)were used to quantify heat-induced CVD burden.We calculated the age-standardized mortality rate(ASMR)and DALY rate(ASDR)per 100,000population to compare this burden across regions.Generalized linear models were applied to evaluate estimated annual percentage changes(EAPC)for temporal trends from 1990 to 2019.The correlation between the socio-demographic index(SDI)and age-standardized rate was measured using the Spearman rank test.Results Heat-induced CVD caused approximately 90 thousand deaths worldwide in 2019.Global ASMR and ASDR of heat-related CVD in 2019 were 1.17[95%confidence interval(CI):0.13-1.98]and 25.59(95%CI:2.07-44.17)per 100,000 population,respectively.The burden was significantly increased in middle and low-SDI regions and slightly decreased in high-SDI regions from 1990 to 2019.ASMR showed an upward trend,with the most considerable increase in low-latitude countries.We observed a negative correlation between SDI and EAPC in ASMR(rs=-0.57,P<0.01)and ASDR(rs=-0.59,P<0.01)among204 countries.Conclusion Heat-attributable CVD burden substantially increased in most developing countries and tropical regions. | HONG Le YAN Miao Miao ZHANG Yun Quan WANG Kai WANG Ya Qi LUO Si Qi WANG Fang | 2023 | Biomedical and Environmental Sciences2023，36，3： | 1 |
| 9 | Acute membrane effects of trimetazidine in human platelets 显示文摘 | Devynck MA Le Quan Sang KH Joulin Y | 1993 | Eur J Pharmacol1993，245，2： | 1 |
| 10 | Discovery and in vitro biosynthesis of haloduracin, a two-component antibiotic 显示文摘 | McClerren AL Cooper LE Quan C | 2006 | Proc NatlAcadSci USA2006，103，17： | 1 |
| 11 | Sustainable and Facile Route to Nearly Monodisperse Spherical Aggregates of CeO2 Nanocrystals with Ionic Liquids and Their Catalytic Activities for CO Oxidation显示文摘 | ZHEN Xingli LE Leli QUAN Yuan | 2008 | Journal of Physical Chemistry C2008，112，18： | 1 |
| 12 | A 95 - Db linear low- power variable gain amplifier, IEEE Trans显示文摘 | Duong Q H Quan Le | 2006 | On Circuits and Systems Ⅰ: Regular Papers2006，53，8： | 1 |
| 13 | A 95-dB linear low-power variable gain amplifier显示文摘 | Duong Q H Le Quan Kim Chang Wan | 2006 | IEEETransactions on Circuits and Systems I: Regular Pa-pers2006，53，8： | 1 |
| 14 | Real time monito- ring system of cutting process based on cutting temperature 显示文摘 | Quan Yanming Zhao Jing Le Youshu | 2009 | Key Engineering Materials2009，，392394： | 1 |
| 15 | Unilateral colloid milium of the arm显示文摘 | Lewis A Le E Quan L | 2002 | J Am Acad Dermatol2002，46，2： | 1 |
| 16 | Constrained planar motion analysis by decomposition 显示文摘 | Long Quan Yichen Wei Le Lu | 2004 | Image and Vision Computing2004，22，： | 1 |
| 17 | Successful treatment of congenital hyperinsulinism with long-acting release octreotide显示文摘 | Le Quan Sang KH Amoux JB Mamoune A | 2012 | Eur J Endocrinol2012，166，2： | 1 |
| 18 | Membrane mi croviscosity and plasma triacylglycerols in the rat 显示文摘 | Devynck MA Kunes J Le - Quan - Sang KH | 2009 | Clin Sci2009，94，1： | 1 |
| 19 | Successful treatment of congenital hyperinsulinism with long-acting release octreotide 显示文摘 | Le Quan Sang K H Arnoux J B Mamoune A | 2012 | Eur J Endocrinol2012，166，2： | 1 |
| 20 | Successful treatment of congenital hyperinsulinism with tong-acting release octreotide显示文摘 | Le Quan Sang KH Arnoux JB Mamoune A | 2012 | Eur J Endocrinol2012，166，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员