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| 1 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 2 | Mitochondrial Composition,Function and Stress Response in Plants显示文摘The primary function of mitochondria is respiration,where catabolism of substrates is coupled to ATP synthesis via oxidative phosphorylation.In plants,mitochondrial composition is relatively complex and flexible and has specific pathways to support photosynthetic processes in illuminated leaves.This review begins with outlining current models of mitochondrial composition in plant cells,with an emphasis upon the assembly of the complexes of the classical electron transport chain (ETC).Next,we focus upon the comparative analysis of mitochondrial function from different tissue types.A prominent theme in the plant mitochondrial literature involves linking mitochondrial composition to environmental stressresponses,and this review then gives a detailed outline of how oxidative stress impacts upon the plant mitochondrial proteome with particular attention to the role of transition metals.This is followed by an analysis of the signaling capacity of mitochondrial reactive oxygen species,which studies the transcriptional changes of stress responsive genes as a framework to define specific signals emanating from the mitochondrion.Finally,specific mitochondrial roles during exposure to harsh environments are outlined,with attention paid to mitochondrial delivery of energy and intermediates,mitochondrial support for photosynthesis,and mitochondrial processes operating within root cells that mediate tolerance to anoxia and unfavorable soil chemistries. | Richard P. Jacoby Lei Li Shaobai Huang Chun Pong Lee A. Harvey Millar Nicolas L. Taylor | 2012 | Journal of Integrative Plant Biology2012，54，11： | 7 |
| 3 | 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia显示文摘 | Dinesh Khanna John D. Fitzgerald Puja P. Khanna Sangmee Bae Manjit K. Singh Tuhina Neogi Michael H. Pillinger Joan Merill Susan Lee Shraddha Prakash Marian Kaldas Maneesh Gogia Fernando Perez‐Ruiz Will Taylor Frédéric Lioté Hyon Choi Jasvinder A. Singh Ni | 2012 | Arthritis Care Res2012，，10： | 4 |
| 4 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 5 | 新型冠状病毒肺炎及其心血管效应:流行病学研究的系统综述显示文摘少数新型冠状病毒肺炎(新冠肺炎)患者病情严重,其特征是炎症、微血管损伤和凝血障碍,可能导致心肌损伤、静脉血栓栓塞症(venous thromboembolism, VTE)和动脉闭塞事件。有心血管病危险因素或既往有心血管病的个体可能面临更大的风险。目的:评估各种环境(包括社区、疗养院和医院)中,与新冠肺炎疑似或确诊病例相关的既往存在心血管合并症的患病率。研究者还评估了疑似或确诊新冠肺炎患者随后发生心血管并发症和临床事件的性质和发生率。 | Pellicori P Doolub G Wong CM Lee KS Mangion K Ahmad M Berry C Squire I Lambiase PD Lyon A McCon-nachie A Taylor RS Cleland JG 刘青(摘译) 练桂丽(审校) | 2021 | 中华高血压杂志2021，29，5： | 3 |
| 6 | Clinical outcomes of pregnancy in women with type 1 diabetes 1 1 The Northern Regional Maternity Survey Office kindly provided corroborative data on congenital abnormalities.显示文摘 | Roy Taylor Choy Lee D Kyne-Grzebalski S.M Marshall J.M Davison | 2002 | Obstetrics & Gynecology2002，，4： | 2 |
| 7 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 8 | 2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis显示文摘 | Dinesh Khanna Puja P. Khanna John D. Fitzgerald Manjit K. Singh Sangmee Bae Tuhina Neogi Michael H. Pillinger Joan Merill Susan Lee Shraddha Prakash Marian Kaldas Maneesh Gogia Fernando Perez‐Ruiz Will Taylor Frédéric Lioté Hyon Choi Jasvinder A. Singh Ni | 2012 | Arthritis Care Res2012，，10： | 2 |
| 9 | Resveratrol Does Not Benefit Patients with Non-alcoholic Fatty Liver Disease显示文摘 | Veronique S. Chachay Graeme A. Macdonald Jennifer H. Martin Jonathan P. Whitehead Trisha M. O’Moore-Sullivan Paul Lee Michael Franklin Kerenaftali Klein Paul J. Taylor Maree Ferguson Jeff S. Coombes Gethin P. Thomas Gary J. Cowin Carl M.J. Kirkpatrick Joh | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 10 | The cellular transducer in damage-stimulated bone remodelling: a theoretical investigation using fracture mechanics 显示文摘 | Taylor D Hazenberg JG Lee TC | 2003 | J Theor Biol2003，225，1： | 1 |
| 11 | DNA methyltransferase 1 -associ ated protein ( DMAP1 ) is a co-repressor that stimulates DNA methy lation globally and locally at sites of double strand bread repair显示文摘 | Lee GE Kim JH Taylor M | 2010 | Biol Chen2010，285，37： | 1 |
| 12 | Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopie endometrium 显示文摘 | Lee B Du H Taylor HS | 2009 | Biol Reprod2009，80，1： | 1 |
| 13 | The development of care pathways and packages in mental health based on the Model of Human Occupation Screening Tool 显示文摘 | Lee S W Morley M Taylor R R | 2011 | Bri J Occup Ther2011，74，6： | 1 |
| 14 | Disease-causing mutations in parkin impair mitochondrial ubiquitination,aggregation,and HDAC6 dependent mitophagy显示文摘 | Lee JY Naqano Y Taylor JP | | 0，，04： | 1 |
| 15 | Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD)显示文摘 | Taylor PA Ehrhardt MJ Lees CJ | | 0，，： | 1 |
| 16 | The infusion of ex vivo activated and expanded CD4+CD25+immune regulatory cells inhibits graft-versus-host disease lethality显示文摘 | Taylor PA Lees CJ Blazar BR | 2002 | Blood2002，99，10： | 1 |
| 17 | Arterial biology for theinvestigation of the treatment effects of reducing cholesterol(ARBI-TER)2:a double-blind,placebo-controlled study of extended-re-lease niacin on atherosclerosis progression in secondary preventionpatients treated with statins显示文摘 | Taylor AJ Sullenberger LE Lee HJ | 2004 | Circulation2004，110，23： | 1 |
| 18 | The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality显示文摘 | Taylor PA Lees CJ Blazar BR | | 0，，10： | 1 |
| 19 | Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease(GVHD)显示文摘 | Taylor PA Ehrhardt M J Lees C J | | 0，，09： | 1 |
| 20 | Cesium removel from high-pH,high-salt wastewater using crystalline silicotitanate sorbent显示文摘 | Jr WALKER J F TAYLOR P A LEE D D | 1999 | Separation Science and Technology1999，34，67： | 1 |
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