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| 1 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 2 | Initial assessment of chest X-ray in thoracic trauma patients: Awareness of specific injuries显示文摘AIM: To compare the reported injuries on initial assessment of the chest X-ray (CXR) in thoracic trauma patients to a second read performed by a dedicated trauma radiologist. METHODS: By retrospective analysis of a prospective database, 712 patients with an injury to the chest admitted to the University Medical Center Utrecht were studied. All patients with a CXR were included in the study. Every CXR was re-evaluated by a trauma radiologist, who was blinded for the initial results. The findings of the trauma radiologist regarding rib fractures, pneumothoraces, hemothoraces and lung contusions were compared with the initial reports from the trauma team, derived from the original patient files. RESULTS: A total of 516 patients with both thorax trauma and an initial CXR were included in the study. After re-evaluation of the initial CXR significantly more lung contusions (53.3% vs 34.1%, P < 0.001), hemothoraces (17.8% vs 11.0%, P < 0.001) and pneumothoraces (34.4% vs 26.4%, P < 0.001) were detected.During initial assessment significantly more rib fractures were reported (69.8% vs 62.3%, P < 0.001). CONCLUSION: During the initial assessment of a CXR from trauma patients in the emergency department, a significant number of treatment-dictating injuries are missed. More awareness for these specific injuries is needed. | Tjeerd S Aukema Ludo FM Beenen Falco Hietbrink Luke PH Leenen | 2012 | World Journal of Radiology2012，4，2： | 3 |
| 3 | Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats 显示文摘 | Huang BS Leenen FHH | 1999 | hypertension1999，34，1： | 2 |
| 4 | 请求权结构与制定法:案例分析法与制定法的互动显示文摘这是无数德国法学院学生的困扰,一方面需要掌握法律规范,另一方面还需要学习如何将这些规范运用于'鉴定书式'的框架中。本文旨在说明,制定法及其各单个规范之间存在内部联系,而'鉴定书式'的案例分析练习与认识和强化制定法规范间的内在联系,互有助益。请求权基础的案例分析方法并不会为我们的法律学习与法学教育平添负担,相反,它自始即服务于更系统化和更条理化地掌握制定法的规定。以'鉴定书式'框架为导向进行思维,可以学会对制定法中的规范进行重新梳理与排序。更为重要的是,在请求权基础的案例分析过程中,学生将自己发现问题,并且意识到规则体系中的断裂和不足之处。 | 贺栩栩(译) | 2016 | 法律方法2016，22，1： | 2 |
| 5 | Brain 'ouahain' in the median preoptic nucleus mediates sodium sensitive hypertension in SHR 显示文摘 | Budzikowski AS Leenen FH | 1997 | Hypertension1997，29，2： | 1 |
| 6 | Twenty-Iwo novel mutations in Ihe lysosomal alpha-glucosidase gene ( GAA ) underscore the genoIype-phenoIype correlation in glycogen sIorage disease Iype Ⅱ 显示文摘 | Hermans MM van Leenen D Kroos MA el al | 2004 | Hum Mutat2004，23，1： | 1 |
| 7 | Some factors influencing the outcome of stoma surgery显示文摘 | Leenen LP Kuypers JH | 1989 | Dis Colon Rectum1989，32，6： | 1 |
| 8 | ANG Ⅱ in median preoptic nucleus and pressor responses to CSF sodium and high sodium intake in SHR 显示文摘 | Budzikowski AS Leenen FH | 2001 | Am J Physiol Heart Cire Physiol2001，281，3： | 1 |
| 9 | Central sympathoinhibitory effects of calcium channel blockers显示文摘 | Leenen FH Ruzicka M Huang BS | 2001 | Curr Hypertens Rep2001，3，4： | 1 |
| 10 | Brain'ouabain'mediates sympathetic hyperactivity in congestive heart failure显示文摘 | Leenen F H H Huang B S Yu H | 1995 | Circ Res1995，77，5： | 1 |
| 11 | Langerhans cell histiocytosis insight into DC biology显示文摘 | Laman JD Leenen PJ Annels NE | 2003 | Trends Immunol2003，24，4： | 1 |
| 12 | Immunotherapeutic strategies in neuroblastoma:antitumoral activity of deglycosylated Ricin A conjugated anti-GD2 antibodies and anti-CD3xanti-GD2 bispecific antibodies显示文摘 | Manzke O Russello O Leenen C | 2001 | Medical and pediatric oncology2001，36，1： | 1 |
| 13 | Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31 (hi) Ly-6C (neg)bone marrow precursors in a mouse model of asthma显示文摘 | van Rijt IS Prims JB Leenen PJ | 2002 | Blood2002，1130，10： | 1 |
| 14 | Langerhans- cell histiocytosis: insight into DC biology 显示文摘 | Laman JD Leenen PJ Annels NE et ol | 2003 | Trends Immunol2003，24，4： | 1 |
| 15 | Keratinocyte growth factor induces expansion of murine peripheral CD4 + Foxp3+ regulatory T cells and increases their thymic output 显示文摘 | Bruinsma M Van Soest P L Leenen P J | 2007 | J Immunol2007，179，11： | 1 |
| 16 | Brain 'ouabain' mediates the sympathoexcitatory and hypertensive effects of high sodium intake in Dahl salt-sensitive rats显示文摘 | Huang BS Leenen FHH | 1994 | Circ Res1994，74，4： | 1 |
| 17 | The dutch contribution to thMBR development in perspective显示文摘 | Vander R H Leenen J | 2001 | H2O MBR Special2001，12，6： | 1 |
| 18 | ALLHAT: what has it taught us so far? 显示文摘 | Leenen FH | 2004 | CMAJ2004，171，： | 1 |
| 19 | Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients:amlodipine versus felodipine extended release显示文摘 | Frans Hh Leenen Elizabeth | 2006 | Journal of hypertension2006，24，1： | 1 |
| 20 | ANG II in median preoptic nucleus and pressor responses to CSF sodium and high sodium intake in SHR显示文摘 | Budzikowski AS Leenen FH | 2001 | Am J Physiol Heart Circ Physiol2001，281，3： | 1 |
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