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| 1 | Dopamine: an immune transmitter显示文摘The dopaminergic system controls several vital central nervous system functions, including the control of movement, reward behaviors and cognition. Alterations of dopaminergic signaling are involved in the pathogenesis of neurodegenerative and psychiatric disorders, in particular Parkinson’s disease, which are associated with a subtle and chronic inflammatory response. A substantial body of evidence has demonstrated the non-neuronal expression of dopamine, its receptors and of the machinery that governs synthesis, secretion and storage of dopamine across several immune cell types. This review aims to summarize current knowledge on the role and expression of dopamine in immune cells. One of the goals is to decipher the complex mechanisms through which these cell types respond to dopamine, in order to address the impact this has on neurodegenerative and psychiatric pathologies such as Parkinson’s disease. A further aim is to illustrate the gaps in our understanding of the physiological roles of dopamine to encourage more targeted research focused on understanding the consequences of aberrant dopamine production on immune regulation. These highlights may prompt scientists in the field to consider alternative functions of this important neurotransmitter when targeting neuroinflammatory/neurodegenerative pathologies. | Sarah Thomas Broome Krystal Louangaphay Kevin AKeay Gian Marco Leggio Giuseppe Musumeci Alessandro Castorina | 2020 | Neural Regeneration Research2020，15，12： | 5 |
| 2 | Liver Transplantation in Alcoholic Patients: Impact of an Alcohol Addiction Unit Within a Liver Transplant Center显示文摘 | Giovanni Addolorato Antonio Mirijello Lorenzo Leggio Anna Ferrulli Cristina D’Angelo Gabriele Vassallo Anthony Cossari Giovanni Gasbarrini Raffaele Landolfi Salvatore Agnes Antonio Gasbarrini | 2013 | Alcohol Clin Exp Res2013，，9： | 2 |
| 3 | Gamma hydroxybutyrric acid(GliB)withdrawal does not occur at therapeutic dosage显示文摘 | Addolorato G Leggio L Abenavoli L | 2005 | Drug Mcohol Depend2005，77，2： | 1 |
| 4 | Experimental analysis of viscoelastic criteria for crack initiation and growth in polymers显示文摘 | R. Frassine M. Rink A. Leggio A. Pavan | 1996 | International Journal of Fracture1996，，1： | 1 |
| 5 | Marked decrease of serum CA125 levers after Denver shunt placement in a patient with cirrhosis and refractory ascites 显示文摘 | Leggio | 2006 | Digestive disease and sciences2006，51，9： | 1 |
| 6 | Acute alcohol intoxication显示文摘 | Luisa Vonghia Lorenzo Leggio Anna Ferrulli | 2008 | European Journal of Internal Medicine2008，19，： | 1 |
| 7 | Phonological grouping is specifically affected in cerebellar patients:a verbal fluency study 显示文摘 | Leggio MG Silveri MC Petrosini L | 2000 | Neurol Neurosurg Psychiat2000，9，1： | 1 |
| 8 | The neuropsychological profile of cerebellar damage:the sequencing hypothesis显示文摘 | Leggio MG Chiricozzi FR Clausi S | 2011 | Cortex2011，47，： | 1 |
| 9 | Cognitive sequencing impairment in patients with focal or atrofic cerebellar damage显示文摘 | Leggio MG Tedesco AM Chiricozzi FR | 2008 | Brain2008，1315，： | 1 |
| 10 | NAC transcription factors, Structurally distinct, functionally diverse 显示文摘 | Olsen A N Ernst H A Leggio L | 2005 | Trends Plant Sci2005，10，2： | 1 |
| 11 | An efficient preparation of N - methyl - alpha - amino acids from N - nosyl - alpha - amino acid phenacyl esters显示文摘 | Leggio A Belsito E L De Marco R | 2010 | J Org Chem2010，75，5： | 1 |
| 12 | Systo-Diastolic vent ricular function in patients with hypertension:an eehoeardiography tissue Doppler evaluation study 显示文摘 | Leggio M Sgorbini L Pugliese M | 2007 | Int J Cardiovase Imaging2007，23，2： | 1 |
| 13 | Marked decrease of serum Ca 125 levels after Denver shunt placement in a patient with cirrhosis and refractory ascites显示文摘 | Leggio L Abenavoli L D'Angelo C | 2006 | Dig Dis Sci2006，51，9： | 1 |
| 14 | Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study显示文摘 | Addolorato G Leggio L Ferrulli A | 2007 | Lancet2007，370，9603： | 1 |
| 15 | A preparation of N -Fmoc - N - methyl - alpha - amino acids and N - nosyl - N - methyl - alpha - amino acids显示文摘 | Di Gioia M L Leggio A Liguori A | 2010 | Amino Acids2010，38，1： | 1 |
| 16 | Systole-diastolic ventricular function in patient a with hypertension:an Echocardiographic disseat doppler imaging evaluation study显示文摘 | Leggio M Sgorbini L Pugliese M | | 0，，： | 1 |
| 17 | Safety and efficacy of baclofen in the treatment of alcohol-dependent patients显示文摘 | Addplorato G Leggio L | 2010 | Curr Pharm Des2010，16，19： | 1 |
| 18 | Tackling dipeptidyl peptidase Ⅳ in neurological disorders显示文摘Dipeptidyl peptidase Ⅳ(DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1(GLP-1), pituitary adenylate cyclase-activating polypeptide(PACAP) and glucose-dependent insulinotropic peptide(GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inhibition of DPP-IV enzyme activity is considered as an attractive treatment option for diabetic patients. Nonetheless, increasing studies support the idea that DPP-IV might also be involved in the development of neurological disorders with a neuroinflammatory component, potentially through its non-incretin activities on immune cells. In this review article, we aim at highlighting recent literature describing the therapeutic value of DPP-IV inhibitors for the treatment of such neurological conditions. Finally, we will illustrate some of the promising results obtained using berberine, a plant extract with potent inhibitory activity on DPP-IV. | Ghaith Al-Badri Gian Marco Leggio Giuseppe Musumeci Rubina Marzagalli Filippo Drago Alessandro Castorina | 2018 | Neural Regeneration Research2018，13，1： | 1 |
| 19 | Determination by gas chromatography/mass spectrometry of p-phenylenediamine in hair dyes after conversion to an imine derivative显示文摘 | Di Gioia M L Leggio A Le Pera A Liguori A Napoli A Perri F | | 0，，： | 1 |
| 20 | Insights into the oxidative degradation of cellulose by a copper metalloenzyme that exploits biomass components显示文摘 | Quinlan R J Sweeney M D Lo Leggio L | | 0，，： | 1 |
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