|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 2 | Role of tissue - plasminogen activator in a mouse model of neonatal white matter lesions : Interaction with plasmin inhibitors and anti - inflammatory drugs 显示文摘 | Leroux P Hennebert O Legros H | 2007 | Neuroscience2007，146，2： | 1 |
| 3 | Impact of growth hor-mone (GH) deficiency and GH replacement upon thymus functionin adult patients显示文摘 | Morrhaye G Kermani H Legros JJ | 2009 | PLoS One2009，4，5： | 1 |
| 4 | Clomiphene, mefformin, or both for infertility in the polycystic ovarysyndrome 显示文摘 | Legro R S Bamhart H X Schlaff W D | 2007 | N Engl J Med2007，356，6： | 1 |
| 5 | The effects of a whole grain enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndromel 显示文摘 | Katcher H I Legro R S Kunselman A R | 2008 | Am J 'Clin Nutr2008，87，1： | 1 |
| 6 | Synergistic effects af CoCI(2) and ROCK inhibition on mesenchymal stem cell differentiation intcJ neuron-like cells 显示文摘 | Paeary E Legros H Valo/le S et ' d | 2006 | J Cell Sci2006，119，13： | 1 |
| 7 | Cancer Research显示文摘 | Pequeux C Breton C Hendrick J C Hagelstein M T Martens H Winkler R Geenen V Legros J J | 2002 | 62(16):46232002，62，16： | 1 |
| 8 | Clomiphene,metformin,or both for infertility in the polycystic ovary syndrome显示文摘 | LEGRO R S BARNHART H X SCHLAFF W D | 2007 | N Engl J Med2007，356，4： | 1 |
| 9 | Cloning, expression,and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT Ⅱ)显示文摘 | LeGros H L J Halim A B GeUer A M | 2000 | Biol Chem2000，275，： | 1 |
| 10 | Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells显示文摘 | Pacary E Legros H Valable S | | 0，，13： | 1 |
| 11 | Intrathecal immune response pattern for improved diagnosis of central nervous system involvement in trypanosomiasis显示文摘 | Lejon V Reiber H Legros D | 2003 | J Infect Dis2003，187，9： | 1 |
| 12 | In situ obser- vation of dislocation nucleation and escape in a sub- micrometre aluminium single crystal 显示文摘 | Oh S H Legros M Kiener D | 2006 | Nature Materials2006，，8： | 1 |
| 13 | Synergistic effects of COC1(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells 显示文摘 | Pacary E Legros H Valable S | 2006 | J Cell Sci2006，119，： | 1 |
| 14 | In situ observation of dislocation nucleation and escape in a submicrometre aluminium single crystal显示文摘 | OH S H LEGROS M KIENER D | 2006 | Nature Materials2006，，8： | 1 |
| 15 | Clomiphene,metformin,or both for infertility in the polycystic ovary syndrome显示文摘 | Legro R S Barnhart H X Schlaff W D | 2007 | N Engl J Med2007，356，6： | 1 |
| 16 | Influence of operating parameters on NO2 emissions from a circulating fluidizcd bed eombustor显示文摘 | ZHAO J GRACE J R LIM C J BRERETON C M H LEGROS R | 1994 | Fuel1994，73，10： | 1 |
| 17 | The role of genes and environment in the etiology of PCOS显示文摘 | Diamanti-Kandarakis E Kandarakis H Legro RS | 2006 | Endocr2006，30，1： | 1 |
| 18 | Clinical qualitative evaluation of the diagnosis of acute otitis media in general practice显示文摘 | Legros JM Hitoto H Gamier F | 2005 | lnt J Pediatr Otorhinolaryngol2005，72，1： | 1 |
| 19 | Letrozole or clomiphene for infertility in the polycystic ovary syndrome 显示文摘 | Legro RS Zhang H | 2014 | N Engl J Med2014，371，15： | 1 |
| 20 | Calcium-activated Potassium Channels in Insect Pacemaker Neurons as Unexpected Target Site for the Novel Fumigant Dimethyl Disulfide显示文摘 | GAUTIER H AUGERJ LEGROS C et a1 | 2008 | J Pharmacol Exp Ther2008，324，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员