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| 1 | Qingyi decoction protects against myocardial injuries induced by severe acute pancreatitis显示文摘BACKGROUND We studied the protective effects of Qingyi decoction(QYD)(a Traditional Chinese Medicine)against severe acute pancreatitis(SAP)-induced myocardial infarction(MI).AIM To study the function and mechanism of QYD in the treatment of myocardial injuries induced by SAP.METHODS Ultrasonic cardiography,hematoxylin and eosin staining,immunohistochemistry,qRT-PCR,western blot,enzyme-linked immunosorbent assays,and apoptosis staining techniques were used to determine the effects of QYD following SAP-induced MI in Sprague-Dawley rats.RESULTS Our SAP model showed severe myocardial histological abnormalities and marked differences in the symptoms,mortality rate,and ultrasonic cardiography outputs among the different groups compared to the control.The expression of serum cytokines[interleukin(IL)-1?,IL-6,IL-8,IL-12,amyloidβ,and tumor necrosis factor-α]were significantly higher in the SAP versus QYD treated group(P<0.05 for all).STIM1 and Orai1 expression in myocardial tissue extracts were significantly decreased post QYD gavage(P<0.001).There was no significant histological difference between the 2-aminoethyl diphenylborinate inhibitor and QYD groups.The SAP group had a significantly higher apoptosis index score compared to the QYD group(P<0.001).CONCLUSION QYD conferred cardio-protection against SAP-induced MI by regulating myocardial-associated protein expression(STIM1 and Orai1). | Lei Li Yong-Qi Li Zhong-Wei Sun Cai-Ming Xu Jun Wu Ge-Liang Liu Ahmed MH Bakheet Hai-Long Chen | 2020 | World Journal of Gastroenterology2020，26，12： | 17 |
| 2 | 槲皮素结合Irinotecan或SN-38治疗或许对胃癌细胞的生长有抑制作用显示文摘目前尚无槲皮素结合irinotecan/SN-38治疗胃癌(GC)的研究报道。本文研究的目的是探讨槲皮素结合iri—notecan/SN-38能否更有效地降低癌细胞转移相关基因和蛋白质的表达,并减缓GC的发展。对象与方法:①体外研究。将经培养后的人类胃癌细胞(AGS)分别放入槲皮素(6.25,12.5,25,50,100μM)、SN-38(2.5,5,25,50,100nM)和槲皮素+SN-38中进行48h等处理后. | 张晗思 Lei CS Hou YC Pai MH | 2018 | 国际老年医学杂志2018，39，2： | 10 |
| 3 | The gene for glycogen-storage diseasetype 1b maps to chromosome 11q23显示文摘 | Annabi B Hiraiwa H Mansfield BC Lei KJ Ubagai T Polymeropoulos MH | 1998 | Am J Hum Genet1998，62，2： | 1 |
| 4 | Cardiopulmonaryresuscitation in the mouse显示文摘 | Lei S Weil MH Tang WCh etal | 2002 | J Appl Physiol2002，93，4： | 1 |
| 5 | Cyclosporine a eye drop- induced elongated eyelashes: a case report 显示文摘 | Lei HL Ku WC Sun MH | 2011 | Case Report Ophthalmo12011，2，： | 1 |
| 6 | Clinical evaluation of the Asian proximal femur intramedullary nail antirotation system ( PFNA - II) for treatment of intertrechanteric fractures 显示文摘 | Li MH Lei W Yang L | 2014 | J Ortho Surg Res2014，9，1： | 1 |
| 7 | Bilateral coronary-to-pulmonary artery fistulas显示文摘 | Huang YK Lei MH Lu MS | 2006 | Ann Thorac Surg2006，82，5： | 1 |
| 8 | Favorable clinical outcome of cervical cancers infected with human papillomavirus type 58 and related types 显示文摘 | Lei HG Sun CA Yu MH | 1999 | Int J Cancer1999，84，： | 1 |
| 9 | Peroxisome proliferators-actirated receptor gamma Pro12Ala gene variant is strongly associated with larger bodyss in the Taiwanese 显示文摘 | Lei HH Chen MH Yang WS | 2000 | Metabolism2000，49，10： | 1 |
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