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| 1 | Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response显示文摘混乱毛细管扩张变异(ATM ) 调停由控制导致照耀的 foci 形成,房间周期检查点,和 apoptosis 的 DNA 损坏反应。然而,在上游的发信号怎么调整 ATM,完全没被理解。这里,我们证明在照耀刺激之上, ATM 与联系并且在 DNA 双海滨裂缝的地点在 Tyr370 (Y370 ) 是由表皮的生长因素受体(EGFR ) 的 phosphorylated。内长的 EGFR 的弄空损害调停 ATM 的 foci 形成,相应再结合,和 DNA 修理。而且,有一个 EGFR kinase 禁止者, gefitinib,块 EGFR 和 ATM 协会的预告的处理,妨碍 CHK2 激活和随后的 foci 形成,和增加放射敏感度。因此,我们揭示 EGFR 直接在 DNA 损坏反应由调整 ATM 激活的批评机制,并且我们的结果建议 ATM Y370 phosphorylation 的地位有潜力用作 biomarker 成层为独自一个的任何一个放射疗法或在有 EGFR 抑制的联合的病人。 | Hong-Jen Lee Li Lan Guang Peng Wei-Chao Chang Ming-Chuan Hsu Ying-Nai Wang Chien-Chia Cheng Leizhen Wei Satoshi Nakajima Shih-Shin Chang Hsin-Wei Liao Chung-Hsuan Chen Martin Lavin K Kian Ang Shiaw-Yih Lin Mien-Chie Hung | 2015 | Cell Research2015，25，2： | 4 |
| 2 | Functional polymorphism rs4072037 in MUC1 gene contributes to the susceptibility to gastric cancer: evidence from pooled 6,580 cases and 10,324 controls显示文摘 | Leizhen Zheng Chen Zhu Jianchun Gu Pan Xi Jiangbo Du Guangfu Jin | 2013 | Molecular Biology Reports2013，，10： | 3 |
| 3 | Prognostic significance of HER2 expression based on trastuzumab for gastric cancer (ToGA) criteria in gastric cancer: an updated meta-analysis显示文摘 | Jianchun Gu Leizhen Zheng Yajie Wang Meiling Zhu Qin Wang Xiaoping Li | 2014 | Tumor Biology2014，，6： | 1 |
| 4 | Molecular basis of gastric cancer development and progression 显示文摘 | Leizhen Zheng Liwei Wang Jaffer Ajani | 2004 | Gastric Cancer2004，7，： | 1 |
| 5 | The surviving rate of a graph for the firefighter problem显示文摘 | Cai Leizhen Wang Weifan | 2009 | SlAM J Discrete Math2009，23，4： | 1 |
| 6 | Labeling planar graphs without 4-cycles with a condition on distance two显示文摘 | WANG Weifan CAI Leizhen | 2008 | J Discrete Ap-plied Mathematics2008，156，： | 1 |
| 7 | Labeling planar graphs without 4-cycles with a conditionon distance two显示文摘 | WANG Weifan CAI Leizhen | | 0，，： | 1 |
| 8 | Effect of Ultrasonication on the Properties of Multi-walled Carbon Nanotubes/Hollow Glass Microspheres/Epoxy Syntactic Foam显示文摘Multi-walled carbon nanotubes(MWCNTs) reinforced hollow glass microspheres(HGMs)/epoxy syntactic foam was fabricated. The effects of ultrasonication on the density, compression strength, and water absorption properties were studied. Better dispersed MWCNTs can be obtained after ultrasonication treatment, but an increasing viscosity will lead to a larger amount of voids during syntactic foam preparation especially when the content of HGMs is more than 70 vol%. The existing voids will decrease the density of epoxy syntactic foam. However, the ultrasonication does not change the compression strength much. Ultrasonication treatment will decrease the water absorption content due to the better dispersion and hydrophobic properties of MWCNTs. But a significant increase of water absorption content occurs when HGMs is more than 70 vol%, which is attributed to the higher viscosity and larger amount of voids. | 亚斌 ZHOU Bingwen YIN Shijian HUANG Bingkun PEI Leizhen JIA Fei 张兴国 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，3： | 1 |
| 9 | Advances of high intensity focused ultra- sound(HIFU) for pancreatic cancer 显示文摘 | Xiaoping L Leizhen Z | 2013 | Int J Hyperthermia2013，29，7： | 1 |
| 10 | Molecular basis of gastric cancer development and progression显示文摘 | Leizhen Zheng Liwei Wang Jaffer Ajani Keping Xie | 2004 | Gastric Cancer2004，，2： | 1 |
| 11 | Labeling planar graphs withom 4-cycles wilh a condition on distance two 显示文摘 | WANG Weifan CAl Leizhen | 2008 | Discrete Applied Mathematics2008，156，： | 1 |
| 12 | Molecular basis of gastric cancer development and progression显示文摘 | Leizhen Zheng Liwei Wang Jaffer Ajani el al | 2004 | Gastric Cancer2004，7，2： | 1 |
| 13 | Molecular basis of gastric cancer development and progression 显示文摘 | Leizhen Zheng Liwei Wang Jaffer Ajani | 2004 | Gastric Cancer2004，7，2： | 1 |
| 14 | Star3 activation regulates the expression of vascular endothelial growth factor and hmnan pancreatic cancer angiogenesis and metastasis 显示文摘 | Daoyan Wei Xiangdong Le Leizhen Zheng | 2003 | Oncogene2003，22，： | 1 |
| 15 | Molecular basis of gastric cancer development and progression显示文摘 | Leizhen Zheng Liwei Wang Jaffer Ajani Keping Xie | 2004 | Gastric Cancer2004，，2： | 1 |
| 16 | Investigation of pre-stall mode and pip inception in high speed compression through the use of correlation integral显示文摘 | BRIGHT M M HELEN K Q WANG Leizhen | 1999 | AEME Journal of Turbomachinary1999，121，4： | 1 |
| 17 | Investigation of pre-stall mode and pip inception in high speed compression through the use of correlation integral 显示文摘 | Bright M M Helen K Q Wang Leizhen | 1999 | AEME Journal of Turbomachinary1999，121，4： | 1 |
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