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| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | In-vitro synergistic effects of double and triple combinations of beta-lactam, vancomycin, and netilmicin against methicillin resistant Staphylococcus aureus strains显示文摘 | Rochon -Edouard S Pestel-Caron M Lemeland JF | 2000 | Antimicrob Agents Chemother2000，44，： | 1 |
| 3 | Bifidobacterium from fermented milks:survival during gastric transit显示文摘 | BERADA N LEMELAND J E LAROCHE G | 1991 | J Dairy Sci1991，74，： | 1 |
| 4 | Tolerance to the glyeopeptides vaneomyein and teieoplanin in eoagulase negative staphylococci 显示文摘 | Bourgeois I Pestercaron M Lemeland JF | 2007 | Antimicrob Agents Chemother2007，51，2： | 1 |
| 5 | Emergence of ex- tended-spectrum beta-lactamases in Pseudomonas aeruginosatabout 24 cases at Rouen University Hos- pital 显示文摘 | David M Lemeland JF Boyer S | 2008 | Pathol Biol (Paris)2008，56，78： | 1 |
| 6 | Bifidobacteriumfrom Fermented Milks:Survival during Gastric Transit显示文摘 | BERRADA N LEMELAND F LAROCHE G | 1991 | Journal ofDairy Science1991，74，2： | 1 |
| 7 | Bifidobacterium from fermented milks:survival during gastric transit显示文摘 | Berrada N Lemeland J F Laroch G | | 0，，02： | 1 |
| 8 | Eff-icacy of pefloxacin-fosfomycin in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus显示文摘 | THAUVIN C LEMELAND J F HUMBERT G | 1988 | Antimicrob Agents Chemother1988，32，6： | 1 |
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