|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Femoral atherosclerosis in an old British population: prevalence and risk factors 显示文摘 | Leng GC Papacosta O Whincup P | 2002 | Atherosclerosis2002，，： | 1 |
| 3 | Application of age-adjusted D- dimer threshold for exclusion thromboembolism (PTE) in older patients : a retrospective study 显示文摘 | Leng O Sitaraaman HB | 2012 | Acute Med2012，11，3： | 1 |
| 4 | femoral atherosclerosis in an old British population: prevalence and risk factors显示文摘 | Leng GC Papacosta O Whincup P | 2002 | Atherosclerosis2002，152，： | 1 |
| 5 | Study of the zinc electroplating process using electrochemical noise technique显示文摘 | ZHANG Z LENG W H CAI O Y CAO F H ZHANG J Q | 2005 | J Electroanal Chem2005，578，2： | 1 |
| 6 | Grading quality of evidence and strength of recotmnendations 显示文摘 | Atkins D Best D Briss PA Eccles M Falck-Ytter Y Flottorp S Guyatt GH Harbour R T Haugh MC Henry D Hill S Jaeschke R Leng G Liberati A Magrini N Mason J Middleton P Mrukowicz J O'Connell D Oxman AD Phillips B Schunemann HJ Edejer TT Varonen H Vist GE Williams JW Jr Zaza S GRADE Working Group | 2004 | BMJ2004，328，7454： | 1 |
| 7 | Femoral atherosclerosis in an older British Population:Prevalence and risk factors显示文摘 | Leng GC Papacosta O Whincup P | 2000 | Atherosclerosis2000，152，： | 1 |
| 8 | GH-deficient dw/dw rats and lit/lit mice show increased Fos expression in the hypothalamic arcuate nucleus following systemic injection of GHreleasing peptide-6显示文摘 | Dickson S L Doutrelant-Viltart O Leng G | 1995 | J Endocrinol1995，146，： | 1 |
| 9 | Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4 显示文摘 | Leng X Noble M Adams PD o | 2002 | Mol Cell Biol2002，22，7： | 1 |
| 10 | Femoral atherosclerosis in old British population:prevalence and risk factors显示文摘 | Leng G C Papacosta O Whincup P | 2002 | Atherosclerosis2002，152，： | 1 |
| 11 | Thermal properties of microsilica and nanosilica filled polypropylene composite with epoxy as dispersing aid 显示文摘 | Leng P B Hazizan M A Lin O H | 2007 | Journal of Reinforced Plastics and Composites2007，26，8： | 1 |
| 12 | Applicationofage-adjustedD-dimerthresh-old for exclusion thromboembolism(PTE)in older patients:a retro-spective study显示文摘 | Leng O Sitaraaman HB | | 0，，03： | 1 |
| 13 | femoral atheroselerosis in an old British population: prevalence and risk factors显示文摘 | Leng GC Papacosta O Whincup P | 2002 | Atherosclerosis2002，152，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员