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| 1 | Modeling the role of public health education in Ebola virus disease outbreaks in Sudan显示文摘Public involvement in Ebola Virus Disease(EVD)prevention efforts is key to reducing disease outbreaks.Targeted education through practical health information to particular groups and sub-populations is crucial to controlling the disease.In this paper,we study the dynamics of Ebola virus disease in the presence of public health education with the aim of assessing the role of behavior change induced by health education to the dynamics of an outbreak.The power of behavior change is evident in two outbreaks of EVD that took place in Sudan only 3 years apart.The first occurrence was the first documented outbreak of EVD and produced a significant number of infections.The second outbreak produced far fewer cases,presumably because the population in the region learned from the first outbreak.We derive a system of ordinary differential equations to model these two contrasting behaviors.Since the population in Sudan learned from the first outbreak of EVD and changed their behavior prior to the second outbreak,we use data from these two instances of EVD to estimate parameters relevant to two contrasting behaviors.We then simulate a future outbreak of EVD in Sudan using our model that contains two susceptible populations,one being more informed about EVD.Our finding show how a more educated population results in fewer cases of EVD and highlights the importance of ongoing public health education. | Benjamin Levy Christina Edholm Orou Gaoue Roselyn Kaondera-Shava Moatlhodi Kgosimore Suzanne Lenhart Benjamin Lephodisa Edward Lungu Theresia Marijani Farai Nyabadza | 2017 | Infectious Disease Modelling2017，2，3： | 2 |
| 2 | Drug-induced liver injury and COVID-19:A review for clinical practice显示文摘Coronavirus disease 2019(COVID-19)consists of a systemic disease that can present many complications.The infection presents broad clinical symptoms and a high rate of transmissibility.In addition to severe acute respiratory syndrome,the patients manifest complications beyond the respiratory system.The frequency of liver damage in COVID-19 patients ranges from 14.8% to 53% of patients.One should pay attention to drug-induced liver injury(DILI)in patients with COVID-19,especially considering the off-label use of drugs in prophylactic and therapeutic regimens applied on large scales.This review aims to present relevant information on the medication used so far in COVID-19 patients and its possible hepatotoxicity.We reviewed liver damage in patients with COVID-19 on PubMed and Virtual Health Library to investigate DILI cases.Four studies were selected,involving the medicines remdesivir,tocilizumab and a pharmacovigilance analysis study.The hepatotoxicity profile of drugs presented in the literature considers use in accordance to usual posology standards for treatment.However,drugs currently used in the management of COVID-19 follow different dosages and posology than those tested by the pharmaceutical industry.The deficiency of uniformity and standardization in the assessment of hepatotoxicity cases hinders the publication of information and the possibility of comparing information among healthcare professionals.It is suggested that severe liver injury in COVID-19 patients should be reported in pharmacovigilance institutions,and physicians should pay attention to any considerable abnormal liver test elevation as it can demonstrate unknown drug hepatotoxicity.Liver disorders in COVID-19 patients and the use of several concomitant off-label medications—with a potential risk of further damaging the liver-should at least be a warning sign for rapid identification and early intervention,thus preventing liver damage from contributing to severe impairment in patients. | Gabriela Xavier Ortiz Gabriele Lenhart Matheus William Becker Karin Hepp Schwambach Cristiane Valle Tovo Carine Raquel Blatt | 2021 | World Journal of Hepatology2021，13，9： | 2 |
| 3 | Backward Bifurcation and Optimal Control in Transmission Dynamics of West Nile Virus显示文摘 | Kbenesh W. Blayneh Abba B. Gumel Suzanne Lenhart Tim Clayton | 2010 | Bulletin of Mathematical Biology2010，，4： | 2 |
| 4 | Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig 显示文摘 | LENHART J A RYAN P L OHLETH K M | 2001 | Endocrinology2001，142，9： | 1 |
| 5 | Comparison of two dif ferent approaches of sensitivity analysis显示文摘 | Lenhart L Eckhardt K Fohrer N | 2002 | Physics and Chemistry of the Earth2002，27，910： | 1 |
| 6 | Pereutaneous therapy of inoperable biliary stenoses and occlusions with a new self- expanding nitinol stent显示文摘 | Zorger N Lenhart M Stratzer M | 2002 | Rofo2002，174，10： | 1 |
| 7 | Cerebral CT angiography in the diagnosis of acute subarachnoid hemorrhage显示文摘 | Bretschneider T Gmeinwieser J | 1997 | Acta Radiol1997，38，5： | 1 |
| 8 | Effects of Land Use Changes on the Nutrient Balance in Mesoscale Catchments显示文摘 | LENHART T FOHRER N FREDE H G | 2003 | Physics and Chemistry of the Earth2003，28，33343536： | 1 |
| 9 | Time-resolved contrast-enhanced magnetic resonance angiography of the carotid arteries: diagnostic aceuracy and inter-observer variability compared with selective catheter angiog- raphy显示文摘 | Lenhart M Framme N Yolk M | 2002 | Invest Radio12002，37，10： | 1 |
| 10 | Comparison of two different approaches of sensitivity analysis显示文摘 | Lenhart T Eckhardt K Fohrer N | 2002 | Phys Chem Earth2002，27，910： | 1 |
| 11 | Optimal Control of the Obstacle for an Elliptic Variational Inequality显示文摘 | D. R. Adams S. M. Lenhart J. Yong | 1998 | Applied Mathematics & Optimization1998，，2： | 1 |
| 12 | Global Stability of a Biological Model with Time Delay 显示文摘 | Lenhart S M Travis C C | 1986 | Proc Amer Math Soc1986，96，1： | 1 |
| 13 | Optimal control of the chemotherapy of HIV显示文摘 | Kirschner D Lenhart S Serbin S | 1997 | Journal of Mathematical Biology1997，35，： | 1 |
| 14 | Optimal control of treatments in a two-strain tuberculosis model显示文摘 | Jung E Lenhart S Feng Z | 2002 | Discrete and Continuous Dynamical Systems-Series B2002，2，4： | 1 |
| 15 | Comparison of twodifferent approachevS of sensitivity analysis 显示文摘 | Lenhart T Eckhardt K Fohrer N | 2002 | Physics andChemistry of the Earth Parts A/B/C2002，27，9： | 1 |
| 16 | Enzymatic modification of the synthetic polymer polyhydroxystyrene显示文摘 | SHAO L KUMAR G LENHART J L | 1999 | Enzyme Microb Technol1999，25，89： | 1 |
| 17 | Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig显示文摘 | Lenhart JA Ryan PL Ohleth KM | 2001 | Endocrinology2001，142，8： | 1 |
| 18 | MDCT of acute mild (nonnecrotizing) pancreatitis: abdominal complications and fate of fluid col lect ions 显示文摘 | Lenhart DK Balthazar EJ | 2008 | Air2008，190，3： | 1 |
| 19 | Superselective arterial embolization with a liquid polyvinyl alcohol copolymer in patients with acute gastrointestinal haemorrhage 显示文摘 | Lenhart M Paetzel C Saekmann M | 2010 | Eur Radiol2010，20，8： | 1 |
| 20 | Contrast-enhanced MRangiography in the routine work-up of the lower extreies arteries显示文摘 | Lenhart M Fmkenzeller T Paetzel C | 2002 | Roof Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr2002，174，10： | 1 |
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