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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer:the ALMANAC trial显示文摘 | Robert EM Lesley F Kissin M | | 0，，09： | 1 |
| 3 | Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats显示文摘 | Megan R D Lesley C F Violetta MG | 2008 | Exp Neurol2008，212，2： | 1 |
| 4 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 5 | Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus显示文摘Dear Editor,Severe Acute Respiratory Syndrome(SARS)has beendescribed as the first pandemic of the 21st century andbetween November 2002 and July 2003,over 8000 peo-ple were infected with the SARS-associated coronavirus(SARS-CoV).Polymorphisms in the human leukocyteantigen(HLA)system have been shown to influencesusceptibility to SARS-CoV but here we were unable | Fang Fang Yuan Zlatibor Velickovic Lesley J Ashton Wayne B Dyer Andrew F Geczy Heather Dunckley Garry W Lynch John S Sullivan | 2014 | Virologica Sinica2014，29，2： | 1 |
| 6 | Blocking IL-25 signal- ling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13 显示文摘 | Jillian L Lesley F Daniel R | 2012 | Gastroenterol2012，47，： | 1 |
| 7 | On theorems of Jackson and Bernstein type in the complex plane显示文摘 | ANDERSON J M HINKKANEN A LESLEY F D | 1988 | Constr Approx1988，4，： | 1 |
| 8 | Advances in the Understanding of Stress Urinary Incontinence and the Promise of Stem - Cell Therapy显示文摘 | Akira F Lesley KC Naoki Y | 2007 | Rev Urol2007，9，： | 1 |
| 9 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 1 |
| 10 | Development of consistently crossable wheat genotypes for alien wheat gene transfer through Wne mapping of theKr] locus显示文摘 | ISABELLE B LESLEY F TRACIE N F | 2009 | Theoreti cal and Applied Genetics2009，119，8： | 1 |
| 11 | Impact of Hepatitis C Virus Infection on Children and Their Caregivers: Quality of Life, Cognitive, and Emotional Outcomes显示文摘 | James R Rodrigue William Balistreri Barbara Haber Maureen M Jonas Parvathi Mohan Jean P Molleston Karen F Murray Michael R Narkewicz Philip Rosenthal Lesley J Smith Kathleen B Schwarz Patricia Robuck Bruce Barton Regino P González-Peralta | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，3： | 1 |
| 12 | Blocking IL-25 signalling protectsagainst gut inflammation in a type-2 model of colitis by suppressingnuocyte and NKT derived IL-13显示文摘 | Jillian L Lesley F Daniel R | 2012 | Gastroenterol2012，47，： | 1 |
| 13 | Randomized muticenter trim of sentinel node biopsy versus standard axillary treatment in oper able breast cancer:The ALMANAC trial显示文摘 | Robert EM Lesley F Kissin M | | 0，，09： | 1 |
| 14 | Practical methods for incorporating summary time-to-event data into Meta-analysis显示文摘 | Jayne F Tierney Lesley A Stewart Davina Ghersi | 2007 | Bio Med Central2007，8，10： | 1 |
| 15 | Medical re-search methodology 显示文摘 | Trang Vu Lesley D Camline F F | 2012 | PLOS ONE2012，12，113： | 1 |
| 16 | Patterns of antidepressant therapy and clinical outcomes among ischaemic stroke survivors显示文摘Background and purpose Depression is common after stroke and is often treated with antidepressant medications(AD).ADs have also been hypothesised to improve stroke recovery,although recent randomised trials were neutral.We investigated the patterns of in-hospital AD initiation after ischaemic stroke and association with clinical and readmission outcomes.Methods All Medicare fee-for-service beneficiaries aged 65 or older hospitalised for ischaemic stroke in participating Get With The Guidelines-Stroke hospitals between April and December 2014 were eligible for this analysis.Outcome measures included days alive and not in a healthcare institution(home time),all-cause mortality and readmission within 1-year postdischarge.Propensity score(PS)-adjusted logistic regression models were used to evaluate the associations between AD use and each outcome measure.We also compared outcomes in patients prescribed selective serotonin reuptake inhibitors(SSRIs)AD versus those prescribed non-SSRI ADs.Results Of 21805 AD naive patients included in this analysis,1835(8.4%)were started on an AD at discharge.Patients started on an AD had higher rates of depression and prior ischaemic stroke,presented with higher admission National Institutes of Health Stroke Scale score and were less likely to be discharged home.Similarly,patients started on an SSRI had lower rates of discharge to home.Adjusting for stroke severity,patients started on an AD had worse all-cause mortality,all-cause readmission,major adverse cardiac events,readmission for depression and decreased home-time.However,AD use was also associated with an increased risk for the sepsis,a falsification endpoint,suggesting the presence of residual confounding.Conclusions Patients with ischaemic stroke initiated on AD therapy are at increased risk of poor clinical outcomes and readmission even after PS adjustment,suggesting that poststroke depression requiring medication is a poor prognostic sign.Further research is needed to explore the reasons why depression is associated with worse outcome,and whether AD treatment modifies this risk or not. | Mark R Etherton Shreyansh Shah Xu Haolin Ying Xian Lesley Maisch Deidre Hannah Brianna Lindholm Barbara Lytle Laine Thomas Eric E Smith Gregg C Fonarow Lee H Schwamm Deepak L Bhatt Adrian F Hernandez Emily C O'Brien | 2021 | Stroke & Vascular Neurology2021，6，3： | 0 |
| 17 | 大脑为何分左右半球显示文摘早在5亿年以前,大脑左右半球就已开始分工协作。科学家一度认为这是人类特有的现象,但现在他们发现,在早期脊椎动物上,语言、惯用“右手”、面孔识别、空间关系处理等特殊功能就已经由不同的大脑半球控制了。 | 彼得·F·麦克尼利奇(Peter F.MacNeilage) 莱斯利·J·罗杰斯(Lesley J.Rogers) 乔治·瓦洛蒂加拉(Giorgio Vallortigara) 冯泽君(翻译) | 2009 | 环球科学2009，，8： | 0 |
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