| 1 | Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells显示文摘转变生长因素 --(TGF-) 在恶意的细胞的各种各样的类型上施加 apoptotic 效果,包括肝癌症细胞。然而, TGF- 由导致 apoptosis 的精确机制仍然保持糟糕已知。在现在的学习,我们显示出那 threonine 32 (Thr32 ) FoxO3 的残余是批评的让 TGF- 在 hepatocarcinoma Hep3B 房间经由 Bim 导致 apoptosis。我们的数据证明 TGF- 在 Thr32 通过特定的 de-phosphorylation 导致了 FoxO3 激活。TGF -- 激活的 FoxO3 与 Smad2/3 合作了调停 Bim 起来规定和 apoptosis。在 Thr32 的 FoxO3 (de ) phosphorylation 被酷蛋白 kinase 调整我 --(CKI-) 。由小分子 D4476 的 CKI 抑制能废除 TGF -- 导致的 FoxO/Smad 激活,反向的 Bim 起来规定,和块顺序的 apoptosis。更重要地, CKI- 和 p32FoxO3 的 deregulated 层次在人的恶意的肝纸巾被发现。一起拿,我们的调查结果建议可能有 FoxO3 的 Thr32 为 TGF 是枢轴的一台 CKI-FoxO/Smad-Bim 在引擎 -- 导致的 apoptosis,为肝癌症治疗使它成为一个潜在的治疗学的目标。 | Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni Junbo Hu Dahai Zhu Quan Chen | 2015 | Protein & Cell2015，6，2： | 3 |
| 2 | CDK1在紫外线诱导的细胞凋亡中重要作用的研究(英文)显示文摘Objective:To find out whether CDK1 could appear the important role in the cell apoptosis that induced by ultraviolet ray.Methods:We constructed two kinds of plasmids, one can expressed CDK1 but mutated the fifth amino acid(group A ) and the other can effectively silence the expression of CDK1(group B).When we transfected these plasmids into the 293 cells and at the same time following ultraviolet radiation, we detected the difference of two group cells' apoptosis ratio by subG1 peak assay and want to clarify the mechanism by Western blot assay.Results:Two kinds of plasmids could effectively express in 293 cells.The apoptosis ratio of group A was higher than the group B(P < 0.01).And the apoptosis ratio of group B was lower than the group C(P < 0.01).Compared with group A and C, the expression of Bcl2 of group B was significantly reduced.Conclusion:CDK1 may take a very important role in the programmed cell death. | Xin Wei Leya He Xiaolan Li Hui Xiao Deding Tao Junbo Hu Jianping Gong | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员