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| 1 | Damage characteristics and constitutive modeling of the 2D C/Si C composite: Part I – Experiment and analysis显示文摘This paper reports an experimental investigation on the macroscopic mechanical behaviors and damage mechanisms of the plain-woven(2D) C/Si C composite under in-plane on- and offaxis loading conditions. Specimens with 15, 30, and 45 off-axis angles were prepared and tested under monotonic and incremental cyclic tension and compression loads. The obtained results were compared with those of uniaxial tension, compression, and shear specimens. The relationships between the damage modes and the stress state were analyzed based on scanning electronic microscopy(SEM) observations and acoustic emission(AE) data. The test results reveal the remarkable axial anisotropy and unilateral behavior of the material. The off-axis tension test results show that the material is fiber-dominant and the evolution rate of damage and inelastic strain is accelerated under the corresponding combined biaxial tension and shear loads. Due to the damage impediment effect of compression stress, compression specimens show higher mechanical properties and lower damage evolution rates than tension specimens with the same off-axis angle. Under cyclic tension–compression loadings, both on-axis and off-axis specimens exhibit progressive damage deactivation behaviors in the compression range, but with different deactivation rates. | Li Jun Jiao Guiqiong Wang Bo Yang Chengpeng Wang Gang | 2014 | Chinese Journal of Aeronautics2014，27，6： | 10 |
| 2 | Damage characteristics and constitutive modeling of the 2D C/SiC composite: Part Ⅱ–Material model and numerical implementation显示文摘In this work, a macroscopic non-linear constitutive model accounting for damage, inelastic strain and unilateral behavior is proposed for the 2D plain-woven C/Si C composite. A set of scalar damage variables and a new thermodynamic potential expression are introduced in the framework of continuum damage mechanics. In the deduced constitutive equations, the material's progressive damage deactivation behavior during the compression loading is described by a continuous function, and different deactivation rates under uniaxial and biaxial compression loadings are also considered. In damage evolution laws, the coupling effect among the damage modes and impediment effect of compression stress on the development of shear damage in different plane stress states are taken into account. Besides, the general plasticity theory is applied to describing the evolution of inelastic strain in tension and/or shear stress state. The Tsai–Wu failure criterion is adopted for strength analysis. Additionally, the material model is implemented as a user-defined material subroutine(UMAT) and linked to the ABAQUS finite element software, and its performance is demonstrated through several numerical examples. | Li Jun Jiao Guiqiong Wang Bo Li Liang Yang Chengpeng | 2015 | Chinese Journal of Aeronautics2015，28，1： | 10 |
| 3 | Cellular apoptosis and Caspase-12 expression in a rat model of progressive spinal cord compression显示文摘BACKGROUND:Studies have demonstrated that the mechanisms underlying cellular apoptosis signal transduction focus on two pathways:intracellular mitochondria and extracellular death receptor.The current evidence supports that signal transduction of cellular apoptosis also includes endoplasmic reticulum stress signal transduction. OBJECTIVE:To observe Caspase-12 expression and cellular apoptosis following ischemia in rats with progressive spinal cord compression,and to verify the influence of endoplasmic reticulum stress on the apoptosis induced by spinal cord injury. DESIGN,TIME AND SETTING:A randomized,controlled,animal trial was performed at the Institute of Neuroscience in Chongqing Medical University between January and October in 2006. MATERIALS:Immunohistochemical kit,diaminobenzidine,and TUNEL kit were purchased from Beijing Zhongshan Biotechnology,China;rabbit anti-rat Caspase-12 monoclonal antibody was provided by Santa Cruz,USA. METHODS:Sixty Wistar rats,aged 3-4 months,were randomly assigned to a model group(n=50), which underwent spinal cord compression in the L_1 segment following L_1 laminectomy and articular process excision to establish a model of progressive spinal cord compression,and a sham-surgery group(n=10),which underwent only laminectomy.Starting with the first day after surgery,the rats were locally anesthetized,the skin was opened,and the screw was rotated by 1/4 of a cycle,twice weekly. MAIN OUTCOME MEASURES:At 3,7,14,21,and 28 days after surgery,rats from each group were anesthetized,and the spinal cords were resected.Pathological changes following spinal cord compression were determined using hematoxylin-eosin staining,Nissl dye,and transmission electron microscopy.The TUNEL method was used to observe neuronal apoptosis in the compressed spinal cord segments.Immunohistochemistry and Western blot were utilized to detect Caspase-12 expression in the compressed segments. RESULTS:Cellular swelling,neural degeneration,and altered endoplasmic reticulum structures were observed at 3 days following compression.Symptoms became gradually aggravated with increasing compression time.Compared with the sham-surgery group,the number of apoptotic neurons was remarkably increased in compressed segments of the model group(P<0.05),and Caspase-12 expression was also shown to increase(P<0.05). CONCLUSION:Neuronal apoptosis was a predominant pathological factor resulting in secondary spinal cord injury during progressive spinal cord compression,and Caspase-12 was shown to be possibly involved in neuronal apoptosis induced by progressive spinal cord compression. | Yijian Liang Kejian Wang Shanquan Sun Wei Li Jianhua Ran Guiqiong He | 2009 | Neural Regeneration Research2009，4，8： | 4 |
| 4 | MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models显示文摘Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues.Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease(AD).However,the role of MKP-1 in AD pathogenesis remains elusive.Here,we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse model.The reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1(Sp1)cis-acting binding elements in the MKP-1 gene promoter.Amyloid-β(Aβ)-induced Sp1 activation decreased MKP-1 expression.However,upregulation of MKP-1 inhibited the expression of both Aβprecursor protein(APP)andβ-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2(ERK)/MAPK signaling pathway.Furthermore,upregulation of MKP-1 reduced Aβproduction and plaque formation and improved hippocampal long-term potentiation(LTP)and cognitive deficits in APP/PS1 transgenic mice.Our results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD,whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related phenotypes.Thus,this study suggests that MKP-1 is a novel molecule for AD treatment. | Yehong Du Yexiang Du Yun Zhang Zhilin Huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 5 | Characteristics of carotid artery disease (CAD) and presenting cerebrovascular symptoms in an aged group显示文摘 | Qingwei Chen Ying Liu Linlin Pei Dazhi Ke Guiqiong Li Wei Deng Wuwei Yao | 2009 | The International Journal of Cardiovascular Imaging2009，，2： | 1 |
| 6 | Characteristics of carotid artery disease (CAD) and presenting cerebrovascular symptoms in an aged group显示文摘 | Qingwei Chen Ying Liu Linlin Pei Dazhi Ke Guiqiong Li Wei Deng Wuwei Yao | 2009 | The International Journal of Cardiovascular Imaging2009，，2： | 1 |
| 7 | Exaet traveling wave solutions of the Whitham-Broer-Kaup and Broer-Kaup-Kupershmidt equations显示文摘 | Xu Guiqiong Li Zhibin | 2005 | Chaos Solitons and Fraetals2005，24，： | 1 |
| 8 | Research of Climatic Zoning Index System of Red Cartridge Kiwifruit in Guizhou显示文摘The climate data of 84 meteorological stations in Guizhou from 1981 to 2010 was used,including the statistical data of daily precipitation,temperature,sunshine hours,evaporation,frost free period and so on. Using the equations of light and heat coefficient,light and heat index,latitude and temperature index,active accumulated temperature,effective accumulated temperature,aridity index,and arid-wet index,the red cartridge kiwifruit zoning index of Guizhou was analyzed and studied. The results showed that the zoning index system for the climatic characteristics of Guizhou mountainous area must be established in order to realize the variety regionalization of red cartridge kiwifruit in Guizhou mountainous area,and ten climatic factors were taken as climatic zoning indexes of red cartridge kiwifruit planting,including active accumulated temperature,effective accumulated temperature,annual average temperature,average temperature of July,light and heat coefficient,light and heat index,latitude and temperature index,frost free period,aridity index and arid-wet index. These indicators were giving a comprehensive evaluation for climate suitability conditions of red cartridge kiwifruit planting,and providing the scientific and reasonable basis for the promotion planting of red cartridge kiwifruit in mountain area of Guizhou. | Chi Zaixiang Xiao Yanlin Li Guiqiong Liu Lijuan Pan Xuyan Gong Xueqin | 2017 | Meteorological and Environmental Research2017，8，6： | 1 |
| 9 | Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells显示文摘 | Li Wang Qingwei Chen Guiqiong Li Dazhi Ke | 2011 | Peptides2011，，1： | 1 |
| 10 | Investigation on a Typical Scattered Lightning Strike Case and Response Measures显示文摘From July 31 to August 1 in 2008,a strong thunderstorm process occurred in Neijiang of Sichuan Province,and a strange scattered lightning strike phenomenon happened in office building of Dongxing Meteorological Bureau in Neijiang.Through a series of investigations and analyses,we found occurrence reason of the scattered lightning strike and improved lightning protection measures. | Wei Li Guiqiong Zhao Ping Wang | 2013 | Meteorological and Environmental Research2013，4，7： | 1 |
| 11 | Dihydroartemisinin ameliorates learning and memory in Alzheimer's disease through promoting autophagosome-lysosome fusion and autolysosomal degradation for Aβclearance显示文摘Dihydroartemisinin(DHA)is the primary active metabolite of Artemisia annua,which is used to treat malaria worldwide.DHA can activate autophagy to remove the harmful or useless su bstances from eukaryotic cells,and maintain the cell viability through autolysosomal degradation system.Autophagy activation and autophagy flux are playing an important neuroprotective role in the CNS,as they accelerate the removal of toxic protein aggregates intracellularly and extracellularly to prevent Alzheimer's disease(AD). | Zhao Yueyang Long Zhimin Ding Ya Jiang Tingting Liu Jiajun Li Yimin Liu Yuanjie Peng Xuehua Wang Kejian Feng Min He Guiqiong | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 12 | Coexistence of dopamine-beta-hydroxylase and activated protein-2 alpha in rat cerebellar Purkinje cells显示文摘BACKGROUND:Tyrosine hydroxylase and phenylethanolamine-n-methyl transferase expression coexist in Purkinje cells of the rat cerebellum.Numerous reports have also been published addressing whether dopamine-beta-hydroxylase(DBH) expression exists in cerebellar Purkinje cells. OBJECTIVE:To investigate the coexistence of DBH and activator protein-2αexpression in rat cerebellar Purkinje cells. DESIGN,TIME AND SETTING:A cell morphological study was performed at the Institute of Neuroscience,Chongqing Medical University,China in May 2007. MATERIALS:Ten healthy Wistar rats,of either gender,aged 14 weeks,served as experimental animals.Rabbit anti-mouse DBH,goat anti-mouse activator protein-2αand rabbit anti-mouseβ-actin (Santa Cruz Biotechnology,Inc.,USA),horseradish peroxidase-labeled goat anti-rabbit IgG, FITC-labeled mouse anti-rabbit IgG,and Cy3-labeled mouse anti-goat IgG(Boster,Wuhan,China), were used in this study. METHODS:Immunohistochemical staining was used to measure the expression of DBH or activator protein-2α,with double-label immunofluorescence being employed to determine coexpression of both,in the cerebellum of 5 randomly selected rats.Western blot assay was utilized to determine the expression of DBH and activator protein-2αin the cerebellum of the remaining 5 rats. MAIN OUTCOME MEASURES:Expression,localization and coexistence of DBH and activator protein-2αin the cerebellum were measured separately. RESULTS:Immunohistochemical staining demonstrated that cerebellar Purkinje cells stained positive for DBH and activator protein-2α.Western blot assay also demonstrated DBH and activator protein-2αexpression in the cerebellum.Double-labeling immunofluorescence showed the coexistence of DBH and activator protein-2αin cerebellar Purkinje cells. CONCLUSION:Norepinephrine and activator protein-2αcoexist in rat cerebellar Purkinje cells. | Kejian Wang Wei Li Shanquan Sun Zhongqin Ren Guiqiong He | 2009 | Neural Regeneration Research2009，4，6： | 0 |
| 13 | Three-dimensional quantum wavelet transforms显示文摘Wavelet transform is being widely used in the field of information processing.One-dimension and two-dimension quantum wavelet transforms have been investigated as important tool algorithms.However,three-dimensional quantum wavelet transforms have not been reported.This paper proposes a multi-level three-dimensional quantum wavelet transform theory to implement the wavelet transform for quantum videos.Then,we construct the iterative formulas for the multi-level three-dimensional Haar and Daubechies D4 quantum wavelet transforms,respectively.Next,we design quantum circuits of the two wavelet transforms using iterative methods.Complexity analysis shows that the proposed wavelet transforms offer exponential speed-up over their classical counterparts.Finally,the proposed quantum wavelet transforms are selected to realize quantum video compression as a primary application.Simulation results reveal that the proposed wavelet transforms have better compression performance for quantum videos than two-dimension quantum wavelet transforms. | Haisheng LI Guiqiong LI Haiying XIA | 2023 | Frontiers of Computer Science2023，17，5： | 0 |
| 14 | miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1- containing AMPA receptors in a mouse model of Alzheimer’s disease显示文摘Alzheimer ’s disease(AD) is a leading cause of dementia in the elderly.Mitogen-activated protein kinase phosphatase 1(MKP-1) plays a neuroprotective role in AD.However,the molecular mechanisms underlying the effects of MKP-1 on AD have not been extensively studied.MicroRNAs(miRNAs) regulate gene expression at the post-transcriptional level,thereby repressing mRNA translation.Here,we reported that the microRNA-429-3p(miR-429-3p) was significantly increased in the brain of APP23/PS45 AD model mice and N2AAPPAD model cells.We further found that miR-429-3p could downregulate MKP-1 expression by directly binding to its 3’-untranslated region(3’ UTR).Inhibition of miR-429-3p by its antagomir(A-miR-429) restored the expression of MKP-1 to a control level and consequently reduced the amyloidogenic processing of APP and Aβ accumulation.More importantly,intranasal administration of A-miR-429 successfully ameliorated the deficits of hippocampal CA1 long-term potentiation and spatial learning and memory in AD model mice by suppressing extracellular signal-regulated kinase(ERK1/2)-mediated GluAl hyperphosphorylation at Ser831 site,thereby increasing the surface expression of GluAl-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors(AMPARs).Together,these results demonstrate that inhibiting miR-429-3p to upregulate MKP-1 effectively improves cognitive and synaptic functions in AD model mice,suggesting that miR-429/MKP-1 pathway may be a novel therapeutic target for AD treatment. | Man Luo Yayan Pang Junjie Li Lilin Yi Bin Wu Qiuyun Tian Yan He Maoju Wang Lei Xia Guiqiong He Weihong Song Yehong Du Zhifang Dong | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 15 | EarthingMethod for Protection of a Railway Rail Weighbridge System against Lightning显示文摘The rail weighbridge system of a railway freight station is introduced firstly,and then the earthing method for protection of the rail weighbridge system against lightning based on YLG-60 equipotential bonding surge protection device is shown. | Li Wei Zhao Guiqiong Wang Ping | 2015 | Meteorological and Environmental Research2015，6，1： | 0 |
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