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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Analysis of the composition of the bacterial community in puffer fish Takifugu obscurus显示文摘 | Yang GM Bao BL Peatman E Li HR Huang LB Ren DM | 2007 | 中国生物学文摘2007，21，8： | 19 |
| 3 | TRH microinjection into DVC enhances motility of rabbits gallbladder via vagus nerve显示文摘TRHmicroinjectionintoDVCenhancesmotilityofrabbitsgalbladderviavagusnerveLIUChuanYong,LIUJingZhang,ZHOUJianHua,WANGHanRu,... | Liu, CY Liu, JZ Zhou, JH Wang, HR Li, ZY Li, AJ Liu, KJ | 1998 | World Journal of Gastroenterology1998，4，2： | 4 |
| 4 | Applications of nanogenerators for biomedical engineering and healthcare systems显示文摘The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment.However,conventional biomedical and healthcare devices have shortcomings such as short service life,large equipment size,and high potential safety hazards.Indeed,the power supply for conventional implantable device remains predominantly batteries.The emerging nanogenerators,which harvest micro/nanomechanical energy and thermal energy from human beings and convert into electrical energy,provide an ideal solution for self-powering of biomedical devices.The combination of nanogenerators and biomedicine has been accelerating the development of self-powered biomedical equipment.This article first introduces the operating principle of nanogenerators and then reviews the progress of nanogenerators in biomedical applications,including power supply,smart sensing,and effective treatment.Besides,the microbial disinfection and biodegradation performances of nanogenerators have been updated.Next,the protection devices have been discussed such as face mask with air filtering function together with real-time monitoring of human health from the respiration and heat emission.Besides,the nanogenerator devices have been categorized by the types of mechanical energy from human beings,such as the body movement,tissue and organ activities,energy from chemical reactions,and gravitational potential energy.Eventually,the challenges and future opportunities in the applications of nanogenerators are delivered in the conclusive remarks. | Wanli Wang Jinbo Pang Jie Su Fujiang Li Qiang Li Xiaoxiong Wang Jingang Wang Bergoi Ibarlucea Xiaoyan Liu Yufen Li Weijia Zhou Kai Wang Qingfang Han Lei Liu Ruohan Zang Mark HRümmeli Yang Li Hong Liu Han Hu Gianaurelio Cuniberti | 2022 | InfoMat2022，4，2： | 2 |
| 5 | Ischemia preconditioning is neu- roprotective in a rat cerebral ischemic injury model through autoph- agy activation and apoptosis inhibition显示文摘 | Xia DY Li W Qian HR | 2013 | Braz J Med Biol Res2013，46，7： | 1 |
| 6 | Expression of bone associated macromolecules by gingival and periodontalligament fibroblasts显示文摘 | Ivanovski S Li H Haase HR | 2001 | J Periodontal Res2001，36，3： | 1 |
| 7 | Cr(VI) reduction at rutile-catalyzed cathode in microbial fuel cells 显示文摘 | Li Y Lu AH Ding HR Jin S Yah YH Wang CQ Zen CP Wang H | 2009 | Electrochem Commun2009，11，7： | 1 |
| 8 | Impaired fibrinolysis and the risk for coronary heart disease显示文摘 | Li jnen HR Collen D | 1996 | Circulation1996，94，9： | 1 |
| 9 | Enhanced inflammatory response of blood monocytes to C- reactive protein in patients with unstable anginal显示文摘 | Li J J Wang HR Huang CX | 2005 | Clin China Acta2005，352，12： | 1 |
| 10 | IRE1 signaling affects cell fate during the unfolded protein response 显示文摘 | Lin JH Li H Yasumura D Cohen HR | 2007 | Science2007，318，5852： | 1 |
| 11 | Remifentanil requirements during sevoflurane administration to block somatic and cardiovascular responses to skin incision in children and adults显示文摘 | Munoz HR Cortinez LI Altermatt FR | 2002 | Anesthesiology2002，97，5： | 1 |
| 12 | Socio-economic factors of bacillary dysentery based on spatial correlation analysis in Guangxi Province, China 显示文摘 | NIE C J LI HR YANG LS | 2014 | PLoS One2014，9，10： | 1 |
| 13 | Transcriptional silencing of the RUNX3 gene by CPG hypermethylation is associated with lung cancer显示文摘 | Li QL Kim HR Lee YH | 2004 | Biochem Biophys Res Commun2004，314，1： | 1 |
| 14 | The influence of statin-fibrate combination therapy on lipids profile and apolipoprotein A5 in patients with acute coronary syndrome显示文摘 | Li XP Gong HR Huang XS | 2013 | Lipids Health Dis2013，12，1： | 1 |
| 15 | Chronic hepatitis B virus infection and pancreatic cancer:a case-control study in southern China显示文摘 | Zhu F Li HR Du GN | | 0，，06： | 1 |
| 16 | Exon scanning by reversetranscriptase polymerase chain reaction for detection of known andnovel EML4-ALK fusion variants in non-small cell lung cancer显示文摘 | Sanders HR Li HR Bruey JM | 2011 | Cancer Genet2011，204，1： | 1 |
| 17 | Enhanced apoptotic response to photodynamic therapy after bcl-2 transfection显示文摘 | Luo Y Li G | 1999 | Cancer Res1999，59，： | 1 |
| 18 | Biochemical and biologic properties of rt-PA del (K296-G302), a recombinat human tissue-type plasminogen activator deletion mutant resistant to plasminogen actiator inhibitor-I 显示文摘 | Li XK Lijnen HR Nelles L | 1992 | Blood1992，79，2： | 1 |
| 19 | Enhanced apoptotic response to photodynamic therapy after bcl-2 transfection 显示文摘 | Kim HR Luo Y Li G | 1999 | Cancer Res1999，59，14： | 1 |
| 20 | Annual electric load forecasting by a least squares support vector machine with a fruit flyoptimization algorithm显示文摘 | LI HZ GUO S ZHAO HR | 2012 | Energies2012，5，11： | 1 |
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