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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 3 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 4 | 肠道微生态失调与高血压的关系显示文摘新出现的证据表明,肠道菌群是维持生理动态平衡的关键,该研究旨在验证微生态失衡的肠道菌群与高血压相关这一假设,因为遗传、环境和膳食因素对肠道菌群和血压有很大影响。方法:从2种高血压模型大鼠和一个小队列患者人群的粪便样本中提取细菌DNA,用于细菌基因组的分析. | 刘莉 叶鹏 Yang T Santisteban MM Rodriguez V Li E Ahmari N Carvajal JM Zadeh M Gong M Qi Y Zubcevic J Sahay B Pepine CJ Raizada MK Mohamadzadeh M | 2015 | 中华高血压杂志2015，23，5： | 4 |
| 5 | Lipopolysaccharide decreasing albumin expression in rat hepatocytes显示文摘The relations of the severity of hypoalbu-minemia to morbidity and mortality of patients with critical illness illustrate the need for better understanding of molecular mechanism of hypoalbuminemia. This study was undertaken to investigate the response of albumin synthesis to lipopolysaccharide(LPS)in rat hepatocytes in vitro in early acute phase of sepsis. METHODS:Hepatocytes were cultured at an initial cell density of 1.5×106 cells/well in 3 ml culture medium. There were two groups of samples which received either normal saline or 1 μg/L LPS randomly. Albumin mRNA in hepatocytes was assessed by reverse transcription-poly-merase chain reaction(RT-PCR) and albumin level in the supernatant was measured by ELISA at 0,2,8,12,24 hours after exposure. Meanwhile, the albumin precursor was evaluated at the same time points by flow cytometry. RESULTS:The quantitative changes of mRNA, albumin precursor and its protein were analogous. All of them tended to decline at 12 hours post-treatment and did not decrease significantly until 24 hours after LPS exposure. Meanwhile, albumin mRNA decreased about 30% and the levels of albumin precursor and albumin reduced approximately 50%. CONCLUSIONS: LPS can inhibit albumin synthesis in rat hepatocytes by prevention of albumin transcription. Moreover, the response of hepatic albumin synthesis to LPS changes with the stage of sepsis process. The results show that albumin metabolism in sepsis is a complicated process and further studies are required to understand the molecular mechanism of LPS-induced hypoalbuminemia in sepsis. | Research Institute of General Surgery, Jinling Hospital, Nanjing 210002, China (Wang XY, Li WQ, Li N and Li JS) and Department of Orthopaedics, Zhongda Hospital, Nanjing 210009, China (Lu J) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 2 |
| 6 | Investigation of the electrochemical and electrocatalytic behavior of single-wall carbon nanotube film on a glassy carbon electrode显示文摘 | Luo H X Shi Z J Li N Q | 2001 | Anal Chem2001，73，5： | 2 |
| 7 | Preparation of Co3O4 nanoparticles by a polymer combustion route显示文摘 | JIU J T GE Y LI X N | 2002 | Materials Letters2002，54，： | 2 |
| 8 | Robust channel estimation for OFDM systems with rapid dispersive fading channels显示文摘 | Li Y Cimini Jr L J Sollenberger N R | 1998 | IEEE Trans Commun1998，46，7： | 2 |
| 9 | Understanding SPKI/SDSI using first-order logic 显示文摘 | Li N Mitchell J | 2006 | International Journal of Information Security2006，5，1： | 1 |
| 10 | Phenotypic analysis of c-Kit expression in epithelial monolayers derived from postnatal rat pancreatic islets 显示文摘 | Wang R Li J Yashpal N | 2004 | J Endocrinol2004，182，1： | 1 |
| 11 | Development and characterization of monoclonal antibody specific to nuclear protein of avian influenza virus type A 显示文摘 | LI N QIN A J SHAO H X | 2008 | Agricuhural Science & Technology2008，9，1： | 1 |
| 12 | Simultaneous detection of classical swine fever virus and North American genotype Porcine reproductive and respiratory syndrome virus using a duplex real-time RT-PCR 显示文摘 | Cheng D Zhao J J Li N | 2008 | J Virol Methods2008，151，2： | 1 |
| 13 | High-temperature oxidation of Fe-Cr alloys in wet oxygen显示文摘 | Shen J N Zhou L J Li T F | 1997 | Oxidation of Metals1997，48，： | 1 |
| 14 | IL-27 regulates IL-12 responsiveness of naive CD4 + T cells through Statl-dependent and-independent mechanisms 显示文摘 | Lucas S Ghilardi N Li J | 2003 | Proc Natl Acad Sci USA2003，100，15： | 1 |
| 15 | Cancer gene therapy using a survivin mutant adenovirus显示文摘 | Wall N R Li J | 2001 | J Clin Invest2001，108，7： | 1 |
| 16 | Work of Adhesion and Contact-Angle Isotherm of Binary Alloys on Ionocovalent Oxides 显示文摘 | Li J G Coudurier L Eustathopoulos N | 1989 | Journal of Materials Science1989，24，： | 1 |
| 17 | On the construction of Boolean functions with optimal algebraic immunity显示文摘 | Li N Qu L J Qi W F | 2008 | IEEE Trans on Information Theory2008，54，3： | 1 |
| 18 | A comprehensive review of current local features for computer vision 显示文摘 | Li J Allinson N M | 2008 | Neurocomputing2008，71，1： | 1 |
| 19 | The scaleless wings mutant in Bombyx mori is associated with a lack of scale precursor cell dif- ferentiation followed by excessive apoptosis 显示文摘 | Zhou Q X Li Y N Shen X J et at | 2006 | Dev Genes Evol2006，216，11： | 1 |
| 20 | Investigation of an arbitrary oriented crack meeting an interface between two elastic materials显示文摘 | Li J Zhang X B Recho N | 1997 | Eur J Mech A:Soids1997，16，5： | 1 |
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