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| 1 | 新型重组腺病毒载体埃博拉疫苗完成1期临床试验显示文摘一种新型的重组5型腺病毒载体埃博拉疫苗完成了1期临床试验。研究结果显示了疫苗的安全性和免疫原型良好,特别是高剂量组在14d就可以产生高水平的特异性抗体和T细胞反应。此前的埃博拉疫苗毒株均来自1976年的扎伊尔(Zaire)埃博拉暴发疫情。来自中国的研究者首次评价了这种利用2014年埃博拉疫情流行毒株和重组5型腺病毒载体方法研制的新型埃博拉疫苗。 | Zhu FC Hou LH Li JX 索罗丹 | 2015 | 中华预防医学杂志2015，49，6： | 36 |
| 2 | Isolation and characterization of bipotent liver progenitor cells from adult mouse显示文摘 | Li WL Su J Yao YC Tao XR Yan YB Yu HY Wang XM Li JX Yang YJ Lau JT HuYP | 2006 | 中国生物学文摘2006，20，5： | 26 |
| 3 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 4 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 5 | Molecular cloning of differentially expressed novel rice genes induced by Magnaporthe grisea显示文摘WE have applied the differential display (D. D.) of mRNA method to detect and clone tran-scripts that were differentially expressed between rice NILs (Near-isogenic lines) H7R (resis-tant) and H7S (susceptible) which were induced by Magnaporthe grisea. The cDNA gene-tags obtained from D. D. analysis were reamplified by PCR and screened by Southern | He, ZH Dong, HT Cheng, SJ Wu, YL Dong, JX Li, DB | 1997 | Chinese Science Bulletin1997，42，20： | 4 |
| 6 | Parallel algorithm for generalized matrix eigen-problem and its application in calculation of crystal electronic structure显示文摘1 Problem and algorithmMANY computing tasks arising from computational physics, chemistry and biology are relatedto solving so-called generalized eigen-decomposition problems. Consider the following general-ized eigen-decomposition problem: | Sun, JC Deng, JX Cao, JW Wang, DS Zhang, WQ Li, J | 1997 | Chinese Science Bulletin1997，42，13： | 2 |
| 7 | Three antinematodal diterpenes from Euphorbia kanbsui 显示文摘 | Shi JX Li ZX Nitoda T | 2007 | Biosci Biotechnol Biochem2007，71，4： | 1 |
| 8 | Generation of cloned transgenic pigs rich in omega-3 fatty acids显示文摘 | L Lai JX Kang R Li | 2006 | Nat Biotechnol2006，24，4： | 1 |
| 9 | Nematophin, a novel antimicrobial substance produced by Xenorhabdus nematophilus (Enterobactereaceae) 显示文摘 | Li JX Chen GH Webster JM | 1997 | Can J Microbiol1997，43，： | 1 |
| 10 | Genetic characterization of a new subtype of Hantaan virus isolated from a hemorrhagic fever with renal syndrome (HFRS) epidemic area in Hubei province, China显示文摘 | Li JL Ling JX Liu DY | 2012 | Arch Virol2012，157，10： | 1 |
| 11 | Diffusion-weighted magnetic resonance imaging of focal hepatic nodules in an experimental hepatocellular carcinoma rat model显示文摘 | Xu H Li X Xie JX | 2007 | Acad Radiol2007，14，： | 1 |
| 12 | The upregulation of glial glutamate transporter-1 participates in the induction of brain ischemic tolerance in rats 显示文摘 | Zhang M Li WB Geng JX Li Q J Sun XC Xian XH | 2007 | J Cereb Blood Flow Metab2007，27，7： | 1 |
| 13 | Simultaneous detection of respir- atory virus by a multiplex reverse transcription polymerase chain re- action combined with flow -through reverse dot blotting assay 显示文摘 | Li PQ Yang ZF Chen JX | 2008 | Diagn Microbiol Infect Dis2008，62，1： | 1 |
| 14 | Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C 显示文摘 | Li Y Zhang S Geng JX | 2013 | Asian Pacific Journal of Cancer Prevention2013，14，8： | 1 |
| 15 | Identification of two pigments and a hydroxystilbene antibiotic from Photorhabdus luminescens显示文摘 | Chen GH Wu HM | 1995 | Applied and Environmental Microbiology1995，61，： | 1 |
| 16 | c-Jun/AP-1 pathway-mediated cyclin D1 expression participates in low dose arsenite-induced transformation in mouse epidermal JB6 C141 cells显示文摘 | Zhang DY Li JX Gao JM | 2009 | Toxicol Appl Pharmacol2009，235，1： | 1 |
| 17 | The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophage显示文摘 | Feng B Yao PM Li YK Zhang DJ Harding HP Rong JX | 2003 | Nat Cell Biol2003，5，9： | 1 |
| 18 | Self-assembly of gold nanoparticles to carbon nanotubes using a thiol-terminated pyrene as interlin- ker显示文摘 | Liu L Wang TX Li JX | 2003 | Chemical Physics Letters2003，367，56： | 1 |
| 19 | Region of interest coding based on multiple bitplanes interleaving 显示文摘 | LI JX ZHU RH DING XX | 2004 | Chongqing: International Computer Congress on Wavelet Analysis and Its Applications and Active Media Technology2004，1，2： | 1 |
| 20 | Analysis of nonadherent apoptotic cells by a quantum dots probe in a microfluidic device for drug screening显示文摘 | ZHAO L CHENG P LI JX | 2009 | Anal Chem2009，81，16： | 1 |
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