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| 1 | CIC-3 chloride channels are essential for cell proliferation and cell cycle progression in nasopharyngeal carcinoma cells显示文摘ClC-3,为激活卷的氯化物编码候选人蛋白质的基因(Cl ?) 隧道,可以涉及肿瘤开发。此处,我们用 antisense 报导研究调查 ClC-3 在鼻咽的癌 CNE-2Z 房间由影响房间增长的机制的击倒的策略。与 immunoblots 和 MTT 试金,我们证明 ClC-3 的表示是房间周期依赖者并且以一种类似的集中依赖者方式,为 ClC-3 特定的 antisense oligonucleotide 禁止了 ClC-3 蛋白质表示和房间增长。ClC-3 的表示水平与房间增长相关。而且在暴露于 ClC-3 antisense oligonucleotide 的房间,克隆的效率被禁止,并且房间在 S 阶段被逮捕。ClC-3 antisense oligonucleotide 禁止了激活卷的 Cl 吗?当前(ICl,体积) 并且以一种集中依赖者方式的规章的体积减少(RVD ) 。另外, ICl,体积或 RVD 断然在对待的房间与房间增长被相关。在结论, ClC-3 通过包含 ICl,体积和 RVD 的调整的机制涉及房间增长和房间周期前进。CIC-3 可以在人的癌症代表一个治疗学的目标。 | Bin Xu Jianwen Mao Liwei Wang Linyan Zhu Hongzhi Li Weizhang Wang Xiaobao Jin Jiayong Zhu Lixin Chen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 12 |
| 2 | PRICE AND SERVICE COMPETITION WITH MAINTENANCE SERVICE BUNDLING显示文摘In many equipment manufacturing industries,firms compete with each other not only on products price,but also on maintenance service.More and more traditional products oriented firms are offering their customers products bundled with maintenance service(P&S bundles).In this study,we examine firms' incentive to offer customers products bundling with long-term maintenance or repair support service in a duopoly competitive environment.When providing P&S bundles,a firm need to determine the service level(in terms of average response time guarantee for the service in this paper) to offer and needs to build a service facility to handle the maintenance service requirements.Based on the analysis of three sub-game models,we characterize the market conditions in which only one firm,both firms or neither firm will offer P&S bundles.Finally,we analyze the affects of serval market factors on firms' strategy choices. | Yi Wang Linyan Sun Rong Qu Gang Li | 2015 | Journal of Systems Science and Systems Engineering2015，24，2： | 6 |
| 3 | NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis显示文摘Cerebral ischemia is a major cause of mortality and long-term morbidity worldwide.NDRG4 has been shown to protect against cerebral ischemia,although the underlying mechanisms remain largely unclear.Here we found that NDRG4 expression was decreased in the brain tissues of ischemia/reperfusion(IR)rats,indicating increased apoptosis rates among cerebral cells.NDRG4 restoration via an adenovirus significantly attenuated cerebral infarct sizes and impairments in IR rats.Furthermore,adenovirus-mediated NDRG4 inhibited cell apoptosis in the brains of IR rats and regulated the expression of Bcl-2,Bax,caspase-3,and c-Fos.Moreover,we found that NDRG4 increased expression of BDNF,which is strongly related to cerebral ischemia and cellular apoptosis.Altogether,our findings demonstrate that NDRG4 protects cerebral IR injury by inhibiting cell apoptosis and regulates cerebral cell apoptosis by increasing BDNF expression.These results suggest that NDRG4 may be a therapeutic target for IR treatment. | Lan Wen Lei Liu Linyan Tong Jinfang Li Keming Zhang Qinbin Zhang Changqing Li | 2019 | Genes & Diseases2019，6，4： | 6 |
| 4 | Research on global change scientific satellites显示文摘Global change now poses a severe threat to the survival and development of mankind.Large-scale,real-time,highly accurate Earth observation from space has become a key technology used to observe global change.China is one of the most influential countries affecting and being affected by global change,yet it has no scientific satellite for global change research so far.Developing global change scientific satellites not only would meet an important demand of China,but also would be a valuable contribution to the world.By analyzing the mechanisms of space-based observation of variables sensitive to global change,this paper explores the concept of global change scientific satellites,and proposes a series of global change scientific satellites to establish a scientific observation system for global environmental change monitoring from space. | GUO HuaDong FU WenXue LI XinWu CHEN Pei LIU Guang LI Zhen WANG Cheng DONG Qing LEI LiPing BAI LinYan LIU QingJie | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 5 | Rise and decline of ancient salt industry revealed by Na and Ca concentrations in sediments at Zhongba site, Chongqing显示文摘基于皇朝的时期分割和 AMS 14 标明日期的 C 在 Zhongba 和 Yuxi 地点表现在沉积的层上,并且另外从 Zhongba 地点和的 201 件沉积样品的 Na, Ca 和 Mg 的分析在 47 沉积 sampl 的 Ca 和 | ZHU Cheng JIANG Fengqing MA Chunmei XU Weifeng HUANG Linyan ZHENG Chaogui LI Lan SUN Zhibin | 2008 | Journal of Geographical Sciences2008，18，3： | 4 |
| 6 | Bacillus licheniformis PF9 improves barrier function and alleviates inflammatory responses against enterotoxigenic Escherichia coli F4 infection in the porcine intestinal epithelial cells显示文摘Background:Enterotoxigenic Escherichia coli(ETEC)F4 commonly colonizes the small intestine and releases enterotoxins that impair the intestinal barrier function and trigger inflammatory responses.Although Bacillus licheniformis(B.licheniformis)has been reported to enhance intestinal health,it remains to be seen whether there is a functional role of B.licheniformis in intestinal inflammatory response in intestinal porcine epithelial cell line(IPEC-J2)when stimulated with ETEC F4.Methods:In the present study,the effects of B.licheniformis PF9 on the release of pro-inflammation cytokines,cell integrity and nuclear factor-κB(NF-κB)activation were evaluated in ETEC F4-induced IPEC-J2 cells.Results:B.licheniformis PF9 treatment was capable of remarkably attenuating the expression levels of inflammation cytokines tumor necrosis factor-α(TNF-α),interleukin(IL)-8,and IL-6 during ETEC F4 infection.Furthermore,the gene expression of Toll-like receptor 4(TLR4)-mediated upstream related genes of NF-κB signaling pathway has been significantly inhibited.These changes were accompanied by significantly decreased phosphorylation of p65 NF-κB during ETEC F4 infection with B.licheniformis PF9 treatment.The immunofluorescence and western blotting analysis revealed that B.licheniformis PF9 increased the expression levels of zona occludens 1(ZO-1)and occludin(OCLN)in ETEC F4-infected IPEC-J2 cells.Meanwhile,the B.licheniformis PF9 could alleviate the injury of epithelial barrier function assessed by the trans-epithelial electrical resistance(TEER)and cell permeability assay.Interestingly,B.licheniformis PF9 protect IPEC-J2 cells against ETEC F4 infection by decreasing the gene expressions of virulence-related factors(including luxS,estA,estB,and elt)in ETEC F4.Conclusions:Collectively,our results suggest that B.licheniformis PF9 might reduce inflammation-related cytokines through blocking the NF-κB signaling pathways.Besides,B.licheniformis PF9 displayed a significant role in the enhancement of IPEC-J2 cell integrity. | Qiao Li Linyan Li Yanhong Chen Changning Yu Paula Azevedo Joshua Gong Chengbo Yang | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 4 |
| 7 | Multi-label Image Classification via Coarse-to-Fine Attention显示文摘Great efforts have been made by using deep neural networks to recognize multi-label images.Since multi-label image classification is very complicated,many studies seek to use the attention mechanism as a kind of guidance.Conventional attention-based methods always analyzed images directly and aggressively,which is difficult to well understand complicated scenes.We propose a global/local attention method that can recognize a multi-label image from coarse to fine by mimicking how human-beings observe images.Our global/local attention method first concentrates on the whole image,and then focuses on its local specific objects.We also propose a joint max-margin objective function,which enforces that the minimum score of positive labels should be larger than the maximum score of negative labels horizontally and vertically.This function further improve our multi-label image classification method.We evaluate the effectiveness of our method on two popular multi-label image datasets(i.e.,Pascal VOC and MS-COCO).Our experimental results show that our method outperforms state-of-the-art methods. | LYU Fan LI Linyan Victor S.Sheng FU Qiming HU Fuyuan | 2019 | Chinese Journal of Electronics2019，28，6： | 3 |
| 8 | Wind power time series simulation model based on typical daily output processes and Markov algorithm显示文摘The simulation of wind power time series is a key process in renewable power allocation planning,operation mode calculation,and safety assessment.Traditional single-point modeling methods discretely generate wind power at each moment;however,they ignore the daily output characteristics and are unable to consider both modeling accuracy and efficiency.To resolve this problem,a wind power time series simulation model based on typical daily output processes and Markov algorithm is proposed.First,a typical daily output process classification method based on time series similarity and modified K-means clustering algorithm is presented.Second,considering the typical daily output processes as status variables,a wind power time series simulation model based on Markov algorithm is constructed.Finally,a case is analyzed based on the measured data of a wind farm in China.The proposed model is then compared with traditional methods to verify its effectiveness and applicability.The comparison results indicate that the statistical characteristics,probability distributions,and autocorrelation characteristics of the wind power time series generated by the proposed model are better than those of the traditional methods.Moreover,modeling efficiency considerably improves. | Zhihui Cong Yuecong Yu Linyan Li Jie Yan | 2022 | Global Energy Interconnection2022，5，1： | 2 |
| 9 | A hybrid wavelet analysis and support vector machines in forecasting development of manufacturing显示文摘 | Guo Xuesong Sun Linyan Li Gang | 2008 | Expert Systems with Applications2008，35，12： | 1 |
| 10 | Multi-Agent coordination schemas in decentralized production systems显示文摘 | LI Gang LI Yongqiang SUN Linyan | 2007 | Lecture Notes in Artificial Intelligence2007，，： | 1 |
| 11 | The impact of supply chain risk on supply chain integration and company performance: a global investigation显示文摘 | Li Zhao Baofeng Huo Linyan Sun Xiande Zhao | 2013 | Supply Chain Management: An International Journal2013，，2： | 1 |
| 12 | Dialkyl phosphinic acids: synthesis and applications as extraction for nickel and cobalt separation 显示文摘 | Li Linyan Xu Shengming Ju Zhongjun | 2010 | Transactions of Nonferrous Metals Soeiety of China2010，20，1： | 1 |
| 13 | Synthesis of organic phosphinic acids and studies on the relationship between their structure and extraction-separation performance of heavy rare earths from HNO3 solutions 显示文摘 | Wang Junlian Xu Shengming Li Linyan | 2013 | Hydrometallurgy2013，137，： | 1 |
| 14 | The evolutionarycomplexity of complex adaptive supply networks: asimulation and case study显示文摘 | LI Gang YANG Hongjiao SUN Linyan | 2010 | International Journal of ProductionEconomics2010，124，2： | 1 |
| 15 | Synthesis oforganic phosjDhinic acids and studies on the relationship betweentheir structure and extraction - separation pe/ormanceof heavy rare earthis from HN03 solutions 显示文摘 | Junlian Wang Shengming Xu Linyan Li | 2013 | Hydrometalluzy2013，21，： | 1 |
| 16 | Dialkylphosphinic acids : synthesis and applications as extractionfor nickel and cobalt separation显示文摘 | Li Linyan Xu Shengming Ju Zhongun | 2010 | Transactions of NonferrousMetals Society of China2010，20，1： | 1 |
| 17 | Dialkyl phos- phinic acids synthesis and applications as extraction for nickel and cobalt separation显示文摘 | LI Linyan XU Shengming JU Zhongjun | 2010 | Transactions of NonferrousMetals Society of China2010，，： | 1 |
| 18 | Recovery of rare earth resources in the cathode materials of hydrogen- nickel batreties显示文摘 | Wu Fang Xu Shengming Li Linyan | 2008 | Trans Nonferrous Met Soc China2008，，： | 1 |
| 19 | First-principles calculations of a high-pressure synthesiezed compound PtC显示文摘 | Li Linyan Yu Wen Jin Changqing | 2005 | J Phys: Condens Mater2005，17，： | 1 |
| 20 | Design and performance of the LLRF control system for CSNS linac显示文摘Objective The China Spallation Neutron Source(CSNS)linac is designed with beam energy of 80 MeV and a peak current of 15 mA in the first phase.It consists of RFQ,two bunchers of medium-energy beam transmission line,four DTL tanks and one debuncher of linac-to-ring beam transmission line.Correspondingly,eight online RF power sources are used to power these accelerators.In order to stabilize the amplitude,phase and resonant frequency of the RF accelerating field,and minimize beam loss,we have established digital low-level RF(LLRF)control system.Methods The LLRF system includes RF reference line,analog module(AM),clock distribution module,digital control module(DCM),high-power protection module,timing and RF interlock module and so on.The DCM is mainly responsible for the stability of the RF field amplitude and phase,and RF interlock module can quickly cut off the RF drive in case of arc in the RF transmission system,VSWR over threshold or cavity vacuum fault and so on.Result During beam commissioning,all of eight online units of LLRF control system were operating stably and reliably.The amplitude and phase variations of the linac fields have been achieved about±0.4%and±0.15°with 10-mA beam loading,much better than the design requirements of±1%in amplitude and±1°in phase.Conclusion With the help of this system,we achieved stable operation under different beam loads.Also,many important progresses have been achieved in the LLRF control system for amore convenient operation and a higher stability performance.This article describes the design and implementation of the LLRF for CSNS linac. | Linyan Rong Zhencheng Mu Jian Li Zhexin Xie Wenzhong Zhou Bo Wang Maliang Wan Meifei Liu Xinan Xu | 2020 | Radiation Detection Technology and Methods2020，4，2： | 1 |
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