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| 1 | Reduction of the incidence and mortality of rectal cancer bypolypectomy:a prospective cohort study in Haining County显示文摘AIM: To reduce the incidence and morlality of rectal cancerand address the hypothesis that colorectal cancer often arisefrom precursor lesion (s), either adenomas or non-alenomatous polyps, by conducting a population-basedmass screening for colorectal cancer in Haining County,Zhejiang, PRCMETHODS: From 1977 to 1980, physicians screened thepopulation of Haining County using 15 cm rigid endoscopy.Of over 240 000 participants, 4076 of them were diagnoselwith Precursor Iesions, eitler alenomas or non-adenomatous polyps, which were then removedl surgically.All individuals with precursor lesionswere followed up andreexamined by endoscopy every two to five years upto 1998.RESULTS: After the initial screening, 953 metactronousadenomas and 417 non-adenomatous polyps ware detected andremoved from the members of this cohort. Further, 27 cases ofcolorectal cancer were detected and treated. Log-rank tuestsshowed that the survival time among those cancer patients whounderwent mass screening increased significantly comparedtothat of other colorectal cancer patients (P < 0.0001). Accordingto the population-based cancer registry in Haining County,age-adjusted incidence and mortality of rectal cancer decreasedby 41% and 29 % from 1977-1981 to 1992-1996, respectively.Observed cumulative 20-year rectal cancer incidence was 31%lower than the expected in the screened group; the mortalitydue to rectal cancer was 18 % lower thah the expected in thescreened group.CONCLUSION: Mass screening for rectal cancer andprecursor lesions with protocoscopy in the generalpopulation and periodical following-up with routineendoscopy for high-risk patients may decrease both theincidence and mortality of rectal cancer. | Shu Zheng Xi-Yong Liu Qi Dong,Cancer Institute,Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Ke-feng Ding Lin-Bo Wang Pei-Lin Qiu Su-Zhan Zhang,The 2~(nd)affiliated Hospital,Medical School of Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Xin-Feng Ding Yong-Zhou Shen Gao-Fei Shen Oi-Rong Sun Wei-Dong Li,Haining Cancer Institute,Haining 314400,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 37 |
| 2 | Evaluation of liver functional reserve by combining D-sorbitol clearance rate and CT measured liver volume显示文摘AIM: Our research attempted to evaluate the overall functional reserve of cirrhotic liver by combination of hepatic functional blood flow, liver volume, and ChildPugh′s classification, and to discuss its value of clinical application.METHODS: Ninety two patients with portal hypertension due to hepatic cirrhosis were investigated. All had a historyof haematemesis and hematochezia, esophageal and gastric fundus varices, splenomegaly and hypersplenia.A 2-year follow-up was routinely performed and no one was lost. Twenty two healthy volunteers were used as control group. Blood and urine samples were collected 4times before and after intravenous D-sorbitol infusion.The hepatic clearance (CLH) of D-sorbitol was then calculated according to enzymatic spectrophotometric method while the total blood flow (QToTAL) and intrahepatic shunt (RINs) were detected by multicolor Doppler ultrasound, and the liver volume was measured by spiral CT. Data were estimated by t-test, variance calculation and chi-squared test. The relationships between all these parameters and different groups were investigated according to Child-Pugh classification and postoperative complications respectively.RESULTS: Steady blood concentration was achieved 120 mins after D-sorbitol intravenous infusion, which was (0.358±0.064) mmoⅠ@L-1 in cirrhotic group and (0.189±0.05)mmol@L-1 in control group (P<0.01). CLH=(812.7±112.4) ml@min-1,QTOTAL=(1280.6±131.4) ml@min-1, and RINS=(36.54±10.65)%in cirrhotic group and CLH=(1248.3±210.5) ml.min-1, QTOTAL=(1362.4-±126.9) ml@min-1, and RINS=(8.37±3.32) % in control group (P<0.01). The liver volume of cirrhotic group was 1057±249 cm3, 851±148 cm3 and 663±77 cm3 in Child A, B and C group respectively with significant difference (P<0.001).The average volume of cirrhotic liver in Child B, C group was significantly reduced in comparison with that in control group (P<0.001). The patient, whose liver volume decreased by 40 % with the CLH below 600 ml@min-1, would have a higher incidence of postoperative complications. There was no strict correspondent relationship between CLH, liver volume and Child-Pugh′s classification.CONCLUSION: The hepatic clearance of D-sorbitol, CT measured liver volume can be reliably used for the evaluation of hepatic functional blood flow and liver metabolic volume. Combined with the Child-Pugh′s classification, it could be very useful for further understanding the liver functional reserve, therefore help determine reasonable therapeutic plan, choose surgical procedures and operating time. | Yi-Ming Li Fan Lv Xin Xu Hong Ji Wen-Tao Gao Tuan-Jie Lei Gui-Bing Ren Zhi-Lan Bai Qiang Li General Surgery Department,the 2~(nd)Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,ShaanXi Province,China | 2003 | World Journal of Gastroenterology2003，9，9： | 16 |
| 3 | Rainfall interception by sand-stabilizing shrubs related to crown structure显示文摘On the edge of the Tengger Desert in northern China,revegetation has changed the landscape from moving dunes to stabilized dunes covered by shrubs,which further modifies the pattern of rainfall redistribution.To study rainfall interception loss by shrubs and its relationship to rainfall properties and crown structure,throughfalls passing through crowns of Artemisia ordosica Krash.and Caragana korshinskii Kom.were measured using nine PVC cups under the canopy of each of the two shrubs during 73 rain events over a three-year period,with total rainfall of 260.9 mm.Interception losses of gross rainfall by A.ordosica and C.korshinskii account for 15% and 27% of the total on a crown area basis,and 6% and 11% on a ground area basis,respectively.Individual throughfall(T) and interception(I) were significantly related to rainfall amount(Pg),duration(D),and intensity(R).Ratios of throughfall to rainfall(T/Pg) and interception to rainfall(I/Pg) were not only significantly related to Pg,D,and R,but also to shrub species,and interactions of species with crown volume(CV) and leaf area index(LAI).Under most rain events,interceptions by C.korshinskii with greater CV and LAI were significantly higher than those by A.ordosica,and more rainfall interception occurred at locations closer to the stems of the two shrubs.For C.korshinskii,I/Pg had a significant positive linear relation with CV and LAI,while T/Pg had a significant negative linear relation with them.CV has a greater influence on T/Pg and I/Pg than does LAI.Using a regression method,canopy water storage capacities are estimated to be 0.52 and 0.68 mm,and free throughfall coefficient to be 0.62 and 0.47 for A.ordosica and C.korshinskii,respectively. | ZhiShan Zhang 1*,XinRong Li 1,XueJun Dong 2,XiaoHong Jia 1,MingZhu He 1,HuiJuan Tan 1 1.Shapotou Desert Research and Experiment Station,Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou,Gansu 730000,China.2.Central Grasslands Research Extension Center,North Dakota State University,Streeter,ND 58483,USA. | 2009 | Research in Cold and Arid Regions2009，1，2： | 9 |
| 4 | Anesthetic myocar- dial protection with sevoflurane显示文摘 | Nader ND Li CM Khadra WZ | 2004 | J Cardiothorac Vasc Anesth2004，18，3： | 1 |
| 5 | Emerging strategies of lignin engineering and degradation for cellulosic biofuel production 显示文摘 | Weng J K Li X Bonawitz ND | 2008 | Curr Opin Biotechnol2008，19，2： | 1 |
| 6 | Anesthetic myocardial protection with sevoflurane显示文摘 | Nader ND Li CM Khadra WZ | 2004 | Cardiothorac Vasc Anesth2004，18，3： | 1 |
| 7 | Anesthetic myocardial protection with sevoflurane显示文摘 | Nader ND Li CM Khadra WZ | 2004 | J Cardiothorac Vase Anesth2004，18，5： | 1 |
| 8 | Anesthetic myocardial protection with sevoflurane显示文摘 | Li CM Khadra WZ et el | 2004 | J Cardiothorac Vasc Anesth2004，18，3： | 1 |
| 9 | Stress-mediated nuclear stabili- zation of p53 is regulated by ubiquitination and importin-alpha3 binding显示文摘 | Marchenko ND Hanel W Li D | 2010 | Cell Death Differ2010，17，2： | 1 |
| 10 | Drug addiction : the neurobiology of behaviour gone away 显示文摘 | Volkow ND Li TK | 2004 | Nat Rev Neurosci2004，5，12： | 1 |
| 11 | Drugs and alcohol: treating and preventing abuse, addiction and their medical consequences 显示文摘 | Volkow ND Li TK | 2005 | Pharmacol Ther2005，108，1： | 1 |
| 12 | Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces显示文摘 | Li L Kapoor A Slikas B Bamidele O S Wang C Shaukat S Masroor M A Wilson M L Ndjango J B Peeters M Gross-Camp ND Muller MN Hahn BH Wolfe ND Triki H Bartkus J Zaidi SZ Delwart E | 2010 | J Virol2010，84，4： | 1 |
| 13 | Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements显示文摘 | Li SP Goldman ND | 1996 | Biochemistry1996，35，28： | 1 |
| 14 | Fc { gamma} R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40^phox regulates NADPH oxidase activity after enzyme assembly on the phagosome显示文摘 | Tian W Li X J Stull ND | 2008 | Blood2008，112，9： | 1 |
| 15 | Wavelet-based nonlinear AGC method for hearing aid loudness compensation 显示文摘 | Li M McAllister HG Black ND | 2000 | IEEEProceedings-Vision Image and Signal Processing2000，147，6： | 1 |
| 16 | Comparison of effects of ivabradine versus carvedilol in murine model with the coxsackievirus B3-induced viral myocarditis显示文摘 | Li YC Zhang T Zhou ND | 2012 | PLoSOne2012，7，6： | 1 |
| 17 | Breast cystic hyperplasia of breast disease patients to prevent显示文摘 | Sun ND Guo XL Li J | 2010 | Chinese J Breast Resection(electronic version)2010，4，2： | 1 |
| 18 | Whole-genome sequence of Schis-tosoma haematobium显示文摘 | Young ND Jex AR Li B | 2012 | Nat Genet2012，44，2： | 1 |
| 19 | Drug addiction: the neurobiology of behaviour gone awry 显示文摘 | Volkow ND Li TK | 2004 | Nat Rev Neurosci2004，5，12： | 1 |
| 20 | Trends and prediction in malignant tumors mortality in past 20 years in China显示文摘 | Li ND Lu FZ Zhang SW | 1997 | Chin J Oncol1997，19，： | 1 |
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