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| 1 | Effect of cis-9,trans-11-conjugated linoleic acid on cell cycle of gastric adenocarcinoma cell line(SGC-7901)显示文摘AIM: To determine the effect of cis-9, trans-1l-conjugated linoleic acid ( c9, tl 1-CLA) on the cell cycle of gastric cancer cells( SGC-7901 ) and its possible mechanism in inhibition cancer growth.METHODS: Using cell culture and immunocytochemicaltechniques, we examined the cell growth, DNA synthesis,expression of PCNA, cyclin A, B1, D1, pl6nink4a and p21clp/wafl ofSGC-7901 cells which were heated with various c9, tll-CLAconcentrations (25,50,100 and 200μnol@L-1)of c9, tll-CLA for 24and 48 h, with a negative control (0.1% ethane).RESULTS: The cell growth and DNA synthesis of SGC-7901cells were inhibited by c9, tll-CLA. SGC-7901 cells. Eightday after treatment with various concentrations of c9, tl1-CLA mentioned above, the inhibition rates were 5.92 % ,20.15 % ,75.61% and 82.44 % ,respectively and inhibitory effeotof c9, tll-CLA on DNA synthesis (except for 25 tmol/L,24h) showed significantly less 3H-TdR incorporation than thatin the negative controls (P < 0. 05 and P < 0. 01).Immunocytochemical staining demonstrated that SGC-7901cells preincubated in media supplemented with different c9,tl1-CLA concentrations at various times significantlydecreased the expressions of PCNA (the expression rateswere7.2-3.0 %,24 h and 9.1-0.9 % at 48 h, respectively),Cyclin A (l1.0-2.3 %, 24 h and 8.5-0.5 % ,48 h), B1 (4.8-1.8% at 24 h and 5.5-0.6 % at 48 h)and D1 (3.6-1.4 % at 24 hand 3.7 %-0 at 48 h) as compared with those in the negativecontrols(the expressions of PCNA, Cyclin A, B1 and D1were 6.5 % at 24h and 9.0 % at 48 h, 4.2% at 24h and5.1% at 48 h, 9.5 % at 24h and 6.0 % at 48 h,respectively)(P< 0.01), whereas the expressions of p16ink4a and p21clp/waf1,cyclin-dependent kinases inhibltors(CDKI), were increased.CONCLUSION: The cell growth and proliferation of SGC-7901cell is inhibited by c9, tll-CLA via blocking the cell cycle,with reduced expressions of cyclin A, B1 and D1 andenhanced expressions of CDKI( p16ink4a and p21cip/waf1). | Jia-Ren Liu Bai-Xiang Li Bing-Qing Chen Ying-ben Xue Yan-Mei Yang Yu-Mei Zheng,Department of Toxicological Health,Public Health College,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Xiao-Hui Han ICU of Cardiological Surgery,The Second Hospital,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Rui-Hai Liu,Food Science and Toxicology,Department of Food Science,Cornell University,Ithaca,NY 14853-7201,USA | 2002 | World Journal of Gastroenterology2002，8，2： | 26 |
| 2 | Friction of Alloys at High Temperature显示文摘A brief review is given about the friction and wear properties of high temperature alloys. Above a critical temperature, if the oxide becomes ductile, it will flow over the surface and prevent metal-to-metat contact. In order to study the tribology of oxide lubrication. a series of tests were carried out using Cu(ReO4)2 as a lubricant. The effects of time. Surface finish. substrates. load and temperature were investigated. A mechanism of lubrication is proposed in which the surface slip predominates along with mechanical attachment of oxide to the surface. | M.B.Peterson (Wear Sciences, 925 Mallard Circle, Arnold Maryland 21012, USA)(To whom correspondence should be addressed)S.J.Calabrese (Rensselaer Polytechnic Institute, Troy, NY, USA)Shizhuo LI and Xiaoxia JIANG (Institute of Metal Research, Chinese Acad | 1994 | Journal of Materials Science & Technology1994，10，5： | 11 |
| 3 | On the Birch-Swinnerton-Dyer Conjecture of Elliptic Curves E_D:y^2=x^3-D^2x | Delang Li Department of Mathematics,Sichuan Union University,Chengdu 610064,P.R.China Ye Tian Department of Mathematics,Columbia University,New York,NY 10027,USA | 2000 | Acta Mathematica Sinica,English Series2000，16，2： | 3 |
| 4 | Evaluation of various solutions for small bowel graft preservation显示文摘EvaluationofvarioussolutionsforsmalbowelgraftpreservationLIYouSheng1,LIJieShou1,LINing1,JIANGZhiWei1,ZHAOYunZhao1,LINan?.. | Li YS Li JS Li N Jiang ZW Zhao YZ Li NY Liu FN | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 5 | Studies of mineral properties at mantle condition using Deformation multi-anvil apparatus显示文摘This paper reports recent studies of the rheological and viscoelastic properties of minerals at mantle pressure and temperature using Deformation multi-anvil apparatus(D-DIA).Stress-strain-time relations were measured using synchrotron X-ray radiation to determine these properties.Rheological properties of San Carlos olivine were measured at pressure up to 10 GPa and indicated that the effect of pressure on the viscosity of olivine is much smaller than previous reported.The unique capability of synchrotron X-ray can resolve the stress heterogeneity within a polycrystalline material as well as within a multi-phase mixture and elucidate the stress-strain distribution in an aggregate.Anelasticity measurements were carried out using olivine as the sample at mantle pressure and temperatures.The results showed that grain boundary activity rather than pressure dominate the relaxation processes.The aim of this paper is to illustrate the methods using new tools for high pressure research. | Li Li MPI,Department of Geosciences,Stony Brook University,Stony Brook,NY 11794,USA | 2009 | Progress in Natural Science:Materials International2009，19，11： | 2 |
| 6 | A risk-associated single nu- cleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population 显示文摘 | Li Xin Yang Xuexi Hu NY | 2011 | Mol Biol Rep2011，38，8： | 1 |
| 7 | Inhibitory effects of autoantibodies on the muscarinie receptors in Sj? gren's syndrome 显示文摘 | Li J Ha YM Kti NY | 2004 | Lab Invest2004，84，11： | 1 |
| 8 | Vascular endothelial growth factor exression in uterine cervical cancer:correlation with clinicopathologic characteristics and survival显示文摘 | Goncharuk IV Vorobjova LI Lukyanova NY | | 0，，03： | 1 |
| 9 | Cultured hippocampal neurons show responses to BDNF,NT-3,and NT-4,but not NGF 显示文摘 | Ip NY Li Y Yancopoulos GD | 1993 | J Neu- rosci1993，13，8： | 1 |
| 10 | A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal,gastric,and lung cancers in a Han Chinese population显示文摘 | Li X Yang XX Hu NY | 2011 | Mol Biol Rep2011，38，8： | 1 |
| 11 | Frequency distribution of synchronized spontaneous otoacoustic emissions showing sex -- dependent differences and asymmetry between ears in 2-- to 4-- day- old neonates显示文摘 | Liu JF Wang NY Li JL | 2009 | Int J Pediatr Otorhinolaryngol2009，73，： | 1 |
| 12 | Effect of platelet-rich plasma and latissimus dorsi muscle flap on osteogenesis and vasculariza- |ion of tissue-engineered bone in dogs显示文摘 | Li NY Yuan RT Chen T | 2009 | J Oral Maxillofac Surg2009，67，9： | 1 |
| 13 | Congenital nephritic syndrome in mice lacking CD2-associated protein 显示文摘 | Shih NY Li J Karpitskii V | 1999 | Science1999，286，： | 1 |
| 14 | Application of distortion product otoaconstic emissions to inflation of the eustachian tube in low frequency tirmitus with normal hearing显示文摘 | Wang H Song NY Li XJ | 2013 | Auris Nasus Larynx2013，14，03： | 1 |
| 15 | Exp ression f anti-HlV envelop eglyeoprotein seFv in Pichia pcLstoris and its biologic activities analysis显示文摘 | Li C Jin NY Wang HW | 2007 | Xi Ban Yu Fen Zi Mian Yi Xue Za Zhi2007，23，12： | 1 |
| 16 | Effect of NaCl on photosynthesis, salt accumulation and ion compartmentation in two mangrove species, Kandelia candel and Bruguiera gymnorhiza显示文摘 | Li NY Chen SL Zhou XY | 2008 | Aquatic Botany2008，88，： | 1 |
| 17 | Association of TCM-bionzheng with T lymphrocytesubsets and thyroidismin patients with diabetes mellitus显示文摘 | Li XM Chen JZ Zhang NY | 2000 | Di-si Jun yi Daxue Xue bao(J Fourth Mil Med Univ)2000，21，2： | 1 |
| 18 | Prognostic value of serum AFP,AFP-L3,and GP73 in monitoring short-term treat- ment response and recurrence of hepatocellular carcinoma after radiofrequency ablation 显示文摘 | Wang NY Wang C Li W | 2014 | Asian Pac J Cancer Prey2014，15，4： | 1 |
| 19 | Expression and characterization of Gag protein of HIV-1 (CN) in Pichia pastoris显示文摘 | Jiang WZ Jin NY Li ZJ Zhang LS Wang HW Zhang YJ Han WY | 2005 | 第二军医大学学报2005，26，11： | 1 |
| 20 | EMP3 overexpression is associ ated with oligodendroglial tumors retaining chromosome arms lp and 19q显示文摘 | Li KK Pang JC Chung NY | 2007 | lnt J Cancer2007，120，4： | 1 |
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