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| 1 | clusterProfiler 4.0:A universal enrichment tool for interpreting omics data显示文摘Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms. | Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan Dai Tingze Feng Lang Zhou Wenli Tang Li Zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu | 2021 | The Innovation2021，2，3： | 40 |
| 2 | Improved peroxidase-mimic property: Sustainable, high- efficiency interfacial catalysis with H2O2 on the surface of vesicles of hexavanadate-organic hybrid surfactants显示文摘 | Kun Chen Aruuhan Bayaguud Hui Li Yang Chu Haochen Zhang Hongli Jia Baofang Zhang Zicheng Xiao Pingfan Wu Tianbo Liu Yongge wei | 2018 | Nano Research2018，11，3： | 2 |
| 3 | Dye-sensitized solar cells based on anatase TiO 2 /multi-walled carbon nanotubes composite nanofibers photoanode显示文摘 | Pingfan Du Lixin Song Jie Xiong Ni Li Lijun Wang Zhenqiang Xi Naiyan Wang Linhui Gao Hongliang Zhu | 2013 | Electrochimica Acta2013，，： | 1 |
| 4 | Geochemical evolution and Metamorphic development of the Early Precambrian in Eastern Hebei,China显示文摘 | Wang Renmin Chen Zhenzhen Li Pingfan | 1985 | Precambrian Research1985，27，： | 1 |
| 5 | The protective effects of Levilactobacillus brevis FZU0713 on lipid metabolism and intestinal microbiota in hyperlipidemic rats显示文摘Levilactobacillus brevis FZU0713, a potential probiotic previously isolated from the traditional brewing process of Hongqu rice wine, may have the beneficial effects on improving lipid metabolism. This study aimed to evaluate the in vivo protective effects and possible mechanism of L. brevis FZU0713 on the disturbance of lipid metabolism in hyperlipidemic rats fed a high-fat diet(HFD). Results showed that oral administration of L. brevis FZU0713 could significantly inhibit obesity, ameliorate the lipid metabolism disorder, including serum/liver biochemical parameters and hepatic oxidative stress in HFD-fed rats. Histopathological result also indicated that dietary intervention of L. brevis FZU0713 could reduce the accumulation of lipid droplets in liver induced by 8 weeks HFD feeding. Furthermore, L. brevis FZU0713 intervention significantly increased the fecal levels of short-chain fatty acids(SCFAs, including acetate, propionate, butyrate, isobutyrate, valerate and isovalerate)in HFD-fed rats, which may be closely related to the changes of intestinal microbial composition and metabolic function. Intestinal microbiota profiling by 16S rRNA gene sequencing revealed that L. brevis FZU0713 intervention significantly altered the relative abundance of Coprococcus, Butyricicoccus, Intestinimonas, Lachnospiraceae FCS020 group, Ruminococcaceae_NK4A214 group, Ruminococcaceae_UCG-005 and UCG-014 at genus levels. Based on Spearman's rank correlation coefficient, serum and liver lipid metabolism related biochemical parameters were positively correlated with genera Ruminococcus, Pediococcus and Lachnospiraceae, but negatively correlated with genera Pseudoflavonifractor, Butyricicoccus and Intestinimonas. Furthermore, liver metabolomics analysis demonstrated that L. brevis FZU0713 had a significant regulatory effect on the composition of liver metabolites in hyperlipidemic rats, especially the levels of some important biomarkers involved in the metabolic pathways of arachidonic acid metabolism, primary bile acid biosynthesis, amino sugar and nucleotide sugar metabolism, taurine and hypotaurine metabolism, biosynthesis of unsaturated fatty acid, fructose and mannose metabolism, tyrosine metabolism, etc. Additionally, oral administration of L. brevis FZU0713 significantly regulated the mR NA levels of liver genes(including Acat2, Acox1, Hmgcr, Cd36, Srebp-1c and Cyp7a1)involved in lipid metabolism and bile acid homeostasis. In conclusion, our findings provide the evidence that L. brevis FZU0713 has the potential to improve disturbance of lipid metabolism by regulating intestinal microflora and liver metabonomic profile. Therefore, L. brevis FZU0713 may be used as a potential probiotic strain to produce functional food to prevent hyperlipidemia. | Xiaoyun Fan Qing Zhang Weiling Guo Qi Wu Jinpeng Hu Wenjian Cheng Xucong Lü Pingfan Rao Li Ni Youting Chen Lijiao Chen | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 6 | Reimagining safe lithium applications in the living environment and its impacts on human,animal,and plant system显示文摘Lithium's(Li)ubiquitous distribution in the environment is a rising concern due to its rapid proliferation in the modern electronic industry.Li enigmatic entry into the terrestrial food chain raises many questions and uncertainties that may pose a grave threat to living biota.We examined the leverage existing published articles regarding advances in global Li resources,interplay with plants,and possible involvement with living organisms,especially humans and animals.Globally,Li concentration(<10 e300 mg kg1)is detected in agricultural soil,and their pollutant levels vary with space and time.High mobility of Li results in higher accumulation in plants,but the clear mechanisms and specific functions remain unknown.Our assessment reveals the causal relationship between Li level and biota health.For example,lower Li intake(<0.6 mM in serum)leads to mental disorders,while higher intake(>1.5 mM in serum)induces thyroid,stomach,kidney,and reproductive system dysfunctions in humans and animals.However,there is a serious knowledge gap regarding Li regulatory standards in environmental compartments,and mechanistic approaches to unveil its consequences are needed.Furthermore,aggressive efforts are required to define optimum levels of Li for the normal functioning of animals,plants,and humans.This review is designed to revitalize the current status of Li research and identify the key knowledge gaps to fight back against the mountainous challenges of Li during the recent digital revolution.Additionally,we propose pathways to overcome Li problems and develop a strategy for effective,safe,and acceptable applications. | Noman Shakoor Muhammad Adeel Muhammad Arslan Ahmad Muhammad Zain Usman Waheed Rana Arsalan Javaid Fasih Ullah Haider Imran Azeem Pingfan Zhou Yuanbo Li Ghulam Jilani Ming Xu Jorg Rinklebe Yukui Rui | 2023 | Environmental Science and Ecotechnology2023，，3： | 0 |
| 7 | A Study on Market Potentialities of Major Apple Import Countries显示文摘 | Pingfan Chang Li Li Hejian Yan | 2005 | Chinese Business Review2005，4，9： | 0 |
| 8 | Analysis of Risk Factors of Postoperative Neurological Complications in Patients with Stanford Type A Aortic Dissection Undergoing Sun’s Procedure显示文摘Objective:This study analyzed the risk factors of neurological complications in patients with Stanford type A aortic dissection after Sun’s procedure in a single-center with the purpose of improving the effects.Methods:From January 2019 to December 2020,the clinical data of 480 patients with Stanford type A aortic dissection,who were treated by Sun’s procedure in our center were retrospectively analyzed.Univariate and multivariate logistic regression analyses were used to determine the risk factors of postoperative neurological complications.According to whether there were neurological complications after surgery,they were divided into two groups:the group with complications(n=70)and the group without complications(n=410).The clinical data of the two groups were collected and compared.Results:There were 70 cases of patients with postoperative neurological complications in 480 cases.The incidence rates of temporary neurological dysfunction(TND)and permanent neurological dysfunction(PND)was 11.5%(55/480)and 3.1%(15/480),respectively.Univariate analysis showed that the age(≥70 years),stroke history,femoral artery intubation and cardiopulmonary bypass(CPB)time were associated with postoperative PND(p<0.05).Renal dysfunction,emergency surgery,postoperative hypernatremia,postoperative hyperglycemia,postoperative hypoxemia,postoperative low cardiac output syndrome,and assisted time of suction influenced the occurrence of postoperative TND(p<0.05).Multivariate logistic regression analysis showed that age(≥70 years),stroke history,femoral artery intubation and CPB time were independent risk factors for PND.Renal dysfunction,emergency surgery,postoperative hypernatremia,postoperative hyperglycemia,postoperative hypoxemia,postoperative low cardiac output syndrome,and aspiration time were independent risk factors for TND.Compared with the two groups,the hospitalization time and ICU time of the patients in the neurological complications group were significantly prolonged,and the mortality rate was significantly increased(p<0.05).Conclusion:There are many risk factors for neurological complications in patients with Stanford type A aortic dissection after surgery.With the improvement of surgical techniques,optimization of cerebral perfusion,and interventions for risk factors,Sun’s procedure remains the preferred treatment for Stanford type A aortic dissection. | Hui Zhang Ruicheng Zhang Hua Zhang Feng Li Jianming Zhao Shen Ma Rujun Zhu Pingfan Wang | 2021 | Journal of Clinical and Nursing Research2021，5，6： | 0 |
| 9 | The Chinese New Year Becomes More and More Internationalized显示文摘With the Chinese New Year celebrations of overseas Chinese,traditional Spring Festival has gone deep into the hearts of the people worldwide.Chinese New Year atmosphere rises with dragon and lion dance Local time on January 26,the second day of the Lunar New Year,Trafalgar Square,London became a happy ocean for the Chinese New Year. | Jia Pingfan Li Jiabao | 2020 | China & The World Cultural Exchange2020，86，2： | 0 |
| 10 | Translocation and transformation of engineered nanomaterials in plant cells and their effect on metabolism显示文摘As the climate worsens and the demand for food grows,so does the interest in nanoagriculture.The interaction between plants and nanomaterials(NMs)has been extensively and intensively examined.However,stopping at the outcome of a phenomenon is often insufficient.Therefore,we introduce three important processes of nanoparticleplant interactions:translocation,transformation,and plant metabolism.During the migration of nanoparticles,size and surface electrical properties are the main determining factors.Additionally,the interaction of nanoparticles with cell membranes is another key aspect of research.The transformation of nanoparticles in plants is mainly due to redox substances.The way that nanoparticles affect plant metabolism may be able to shed light on the interaction of nanoparticles with plants.This review adds to the existing knowledge on the design of nanoagrochemicals and summarizes the mechanism of interaction of NMs with plants.In this way,NMs can be used for their beneficial effects and thus contribute to the maintenance of food security and sustainable development. | WEICHEN ZHAO PINGFAN ZHOU BENZHEN LOU YAQI JIANG YUANBO LI MINGSHU LI NOMAN SHAKOOR YUKUI RUI | 2023 | BIOCELL2023，47，3： | 0 |
| 11 | Crashworthiness Design and Multi-Objective Optimization of Bionic Thin-Walled Hybrid Tube Structures显示文摘Thin-walled structures are widely used in cars due to their lightweight construction and energy-absorbing properties.However,issues such as high initial stress and lowenergy-absorbing efficiency arise.This study proposes a novel energy-absorbing structure inwhich a straight tube is combinedwith a conical tube and a bamboo-inspired bulkhead structure is introduced.This configuration allows the conical tube to flip outward first and then fold together with the straight tube.This deformation mode absorbs more energy and less peak force than the conical tube sinking and flipping inward.Through finite element numerical simulation,the specific energy absorption capacity of the structure is increased by 26%compared to that of a regular circular cross-section tube.Finally,the impact resistance of the bionic straight tapered tube structure is further improved through multi-objective optimization,promoting the engineering application and lightweight design of hybrid cross-section tubes. | Pingfan Li Jiumei Xiao | 2024 | Computer Modeling in Engineering & Sciences2024，139，4： | 0 |
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