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| 1 | Magnetic resonance imaging of hepatocellular carcinoma induced by diethylnitrosamine in Sprague-Dawley rats显示文摘Diethylnitrosamine (DENA) is able to induce various benign and malignant liver lesions in rats with a high success rate and a low mortality rate. It provides a more appropriate model that better simulates the various lesions occurring in humans than the usual model of tumor implantations. The aim of the present study was to evaluate MRI liver examination in Sprague-Dawley(SD) rats as a routine method to detect hepatocellular carcinoma (HCC) nodules induced by DENA and to follow up their growth. METHODS:Hepatic carcinogenesis was induced in 80 male SD rats using oral DENA solution. All animals were imaged for liver tumor detection with a 1.5 Tesla magnet (Siemens Sonata,Erlangen, Germany) using correspondence scan parameters and a radio-frequency knee coil. Macroscopic examinations were performed along the axial MRI sections to evaluate magnetic resonance imaging (MRI) findings, and histopathological assessment was also performed. RESULTS:No false negative results were obtained on MR images. Hepatic tumors in 72 rats were confirmed macro-scopically and 68 rats were detected by MRI till the 20th week. The smallest and the largest nodules detected by MRI were 2 mm and 37 mm in diameter respectively. The agreement rate of MRI with macroscopic observation was 39. 1% and 97. 4% respectively for 2 mm to 5 mm and more than 5 mm nodules. CONCLUSIONS:The hepatic tumor induced by DENA provides a more representative range of tumors for imaging diagnosis and interventional treatment. MRI is the best approach for scrutinizing pathological changes of rat livers in the period of observation. | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China (Li X, Zhou XP and Guan YS) Department of Radiology, Ruijin Hospieal. Shanghai Second Medical University, Shanghai 200025 , China. Current address:Astra Zeneca R & D Alderley, Macclesfield SK 10 4 TG U. K. (Wang YX) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 2 | BM P4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways 显示文摘 | Qi x Li TG Hao J | 2004 | Proc Natl Acad Sci USA2004，101，16： | 1 |
| 3 | Mir-146a suppresses inva- sion of pancreatic cancer cells显示文摘 | Li Y Vandenboom TG 2nd Wang Z | 2010 | Cancer Res2010，70，4： | 1 |
| 4 | Sucrose regulation of ADP-glucose pyrophosphorylase subunit genes transcript levels in leaves and fruits显示文摘 | Li X Xing J Gianfagna TG | 2002 | Plant Sci2002，162，： | 1 |
| 5 | Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles 显示文摘 | Beach TG Wilson JR Sue LI | 2007 | Acta Neuropathol2007，113，1： | 1 |
| 6 | Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelialmesenchymal transition in gemcitabine resistant pancreatic cancer cells显示文摘 | Li Y VandenBoom TG 2nd Kong D | | 0，，16： | 1 |
| 7 | Multi-organ distribution of phosphorylated alpha - synuclein histopathology in subjects with Lewy body disorders 显示文摘 | Beach TG Adler CH Sue LI | 2010 | Acta Neuropathol2010，119，6： | 1 |
| 8 | Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mes- enchymal transition in gemcitabine-resistant pancreatic cancer cells 显示文摘 | Li Y VandenBoom TG 2nd Kong D | 2009 | Cancer Res2009，69，16： | 1 |
| 9 | The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease显示文摘 | Beach TG Sue LI | 2001 | Mol Med2001，7，： | 1 |
| 10 | BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways显示文摘 | Qi X Li TG Hao J | 2004 | Proc Natl Acad Sci USA2004，101，16： | 1 |
| 11 | Molecular epidemiology of adenovirus infection among pediatric population with diarrhea in Asia显示文摘 | Li L Phan TG Nguyen TA | 2005 | Microbiol hnmuno12005，49，2： | 1 |
| 12 | DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer显示文摘 | Zheng Z Chen TG Li XL | 2007 | N Engl J Med2007，356，8： | 1 |
| 13 | Up-regulation of miR- 200 and let-7 by natural agents leads to the reversal of epithelial-to- mesenchymal transition in gemcitabine-resistant pancreatic cancer cells显示文摘 | Li Y VandenBoom TG 2nd Kong D | 2009 | Cancer Res2009，69，16： | 1 |
| 14 | Rapid detection of tetramethylenedisulfotetramine in human blood by solid-phase microextraction/gas chromatography显示文摘 | Luan TG Li GK Zhao MQ | 2000 | Anal Chim Acta2000，404，： | 1 |
| 15 | Effect of immobilization and performance status on intrafraction motion for ster- eotaetic lung radiotherapy : Analysis of 133 patients 显示文摘 | Li W Purdie TG Taremi M | 2010 | Int J Radia Oncol Biol Phys2010，9，7： | 1 |
| 16 | Both glutamate receptor antagonists and prefrontal cortex lesions prevent induction of cocaine sensitization and associated neuroadaptations 显示文摘 | Li Y Hu XT Berney TG | 1999 | Synapse1999，34，： | 1 |
| 17 | miR-146a suppresses invasion of pancreatic cancer cells显示文摘 | Li Y Vandenboom TG 2nd Wang Z | | 0，，： | 1 |
| 18 | Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells显示文摘 | Li Y VandenBoom TG 2nd Kong D | 2009 | Cancer Res2009，69，16： | 1 |
| 19 | Circle of Willis atherosclerosis:association with Alzheimer' s disease ,neuritic plaques and neurofibrillary tangles显示文摘 | Beach TG WilsonJR Sue LI | 2007 | Acta Neuro-pathol2007，113，1： | 1 |
| 20 | Molecular epidemiology of adenovirus infection among pediatric population with diarrhea in Asia显示文摘 | Phan TG Nguyen TA | 2005 | Microbiol Immunol2005，49，： | 1 |
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