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| 1 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 2 | Metabolic syndrome and colorectal neoplasms:An ominous association显示文摘AIM:To evaluate the association of metabolic syndrome(MS) and colorectal cancer and adenomas in a Western country,where the incidence of MS is over 27%.METHODS:This was a prospective study between March 2013 and March 2014.MS was diagnosed according to the National Cholesterol Education ProgramATP III.Demographic characteristics,anthropometric measurements,metabolic risk factors,and colonoscopic pathologic findings were assessed in patients with MS(group 1) who underwent routine colonoscopy at our department.This data was compared with consecutive patients without metabolic syndrome(group 2),with no differences regarding sex and age.Patients with incomplete colonoscopy,family history,or past history of colorectal neoplasm were excluded.Informed consent was obtained and the ethics committee approved this study.Statistical analysis was performed using Student's t-test and χ2 test,with a P value ≤ 0.05 being considered statistically significant.RESULTS:Of 258 patients,129 had MS;51% males;mean-age 67.1 years(50-87).Among the MS group,94% had high blood pressure,91% had increased waist circumference,60% had diabetes,55% had low high-density lipoprotein cholesterol level,50% had increased triglyceride level,and 54% were obese [body mass index(BMI) 30 kg/m2].51% presented 4 criteria of MS.MS was associated with increased prevalence of adenomas(43% vs 25%,P = 0.004) and colorectal cancer(13% vs 5%,P = 0.027),compared with patients without MS.MS was also positively associated with multiple(≥ 3) adenomas(35% vs 9%,P = 0.024) and sessile adenomas(69% vs 53%,P = 0.05).No difference existed between location(P = 0.086),grade of dysplasia(P = 0.196),or size(P= 0.841) of adenomas.In addition,no difference was found between BMI(P = 0.078),smoking(P = 0.146),alcohol consumption(P = 0.231),and the presence of adenomas.CONCLUSION:MS is positively associated with adenomas and colorectal cancer.However,there is not enough information in western European countries to justify screening in patients with MS.To our knowledge,no previous study has evaluated this association in Portuguese patients. | Daniel Trabulo Suzane Ribeiro Cláudio Martins Cristina Teixeira Cláudia Cardoso Jo?o Mangualde Ricardo Freire élia Gamito Ana L Alves Fátima Augusto Ana P Oliveira Isabelle Cremers | 2015 | World Journal of Gastroenterology2015，21，17： | 5 |
| 3 | 氮素改变辣椒初级代谢和薄壁组织厚度调控比叶面积研究显示文摘比叶面积(SLA)是影响植物光截获和光利用效率的关键性状,常常影响植物的生长和产量。SLA是解释不同植物在不同环境下生长差异的一个关键性状。光照和氮素供应都是决定SLA的重要因素。为了更好地了解辐照度和氮素对辣椒(Capsicum chinense)SLA的影响,研究对两个中国辣椒商品种(Biquinho和Habanero)的初级代谢产物和形态特征进行了分析。两种基因型辣椒的SLA随着遮阴而增加,但随氮供应量的增加而下降;在氮素供应由缺乏到充足的范围内Habanero品种的SLA表现稳定。相关分析表明,高氮供应导致SLA降低是因为氨基酸、蛋白质和淀粉含量的调节,从而影响叶片密度。此外,在中度缺氮到充足供氮范围内,两种基因型辣椒的SLA表现出响应差异,Biquinho和Habanero分别在栅栏和海绵状薄壁组织上表现出差异。总之,结果表明,SLA对氮供应的反应是由某些代谢物含量和依赖于基因型的影响叶片厚度及密度的薄壁组织变化平衡调节的。 | Lucas de ávila Silva Rebeca P.Omena-Garcia Jorge A.Condori-Apfata Paulo Mafra de Almeida Costa Natália Machado Silva Fábio M.Da Matta Agustin Zsogon Wagner L.Araújo Edgard A.de Toledo Picoli Ronan Sulpice Adriano Nunes-Nesi 沈凌峰 吉雪花(译) | 2021 | 辣椒杂志2021，，3： | 2 |
| 4 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 5 | Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?显示文摘 | Cecília Dur?es Gabriela M. Almeida Raquel Seruca Carla Oliveira Fátima Carneiro | 2014 | Virchows Archiv2014，，： | 2 |
| 6 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 7 | Omentin inhibits TNF - α - induced ex- pression of adhesion molecules in endothelial cell via ERK/NF - B pathway显示文摘 | Zhong X Li X Lia F | 2012 | Biochem Biophys Res Commun2012，425，5： | 1 |
| 8 | Orbital interactions in hydrogen bonds important for cohesion in molecular crystals and mismatched pairs of DNA bases显示文摘 | Célia Fonseca Guerra F Matthias Bickelhaupt Evert Jan Bacrends | 2002 | Crystal Growth & Design2002，2，3： | 1 |
| 9 | Severe aortic regurgitation and reduced left ventricular ejection fraction: Outcomes after isolated aortic valve replacement and combined surgery显示文摘 | Alessandro Sionis Ana García-Alvarez María ángeles Castel Marco Cordero Miguel Josa Félix Pérez-Villa Eulàlia Roig | 2010 | Journal of Heart and Lung Transplantation2010，，4： | 1 |
| 10 | Tracking control of a manipulator under uncertainty by Fuzzy PID controller显示文摘 | Lia W Changa X G Wahlb F M | 2001 | Fuzzy Sets and Systems2001，122，1： | 1 |
| 11 | Internet use and risk behaviours: an online survey of visitors to three gay websites in China显示文摘 | Zhang D Bi P Lia F etal | 2007 | Sex Transm Infect2007，83，7： | 1 |
| 12 | Adsorptive removal of 2,4-DCP from water by fresh or regenerated chitosan/ACF/TiO2 membrane显示文摘 | Li F Lia P Zhang H | 2010 | Separation and Purification Technology2010，70，3： | 1 |
| 13 | The effect of surface roughness on early in vivo plague colonization on titanium显示文摘 | LIA R SILCIA F EUGENIO B | 1997 | J Periodanntol1997，68，： | 1 |
| 14 | Targetting transcription factor NF-κB to overcome che- moresistance and radioresistance in cancer therapy 显示文摘 | Lia F Sethi G | 2009 | Biochimi Bio- phys Acta2009，1805，2： | 1 |
| 15 | An automated fast transfer system at the research reactor Munich显示文摘 | Lia X Henkelmann R Baumgartner F | 2004 | Nuclear Instruments and Methods in Physics Research A2004，522，： | 1 |
| 16 | Effect of NTAaddition on the formations,tructure and activity of the ac-tive phase of cobalt-molybdenum sulfide hydrotreating cat-alysts显示文摘 | Lélias M A van Gestel J MaugéF | 2008 | Catalysis Today2008，130，1： | 1 |
| 17 | Synthesis and characterization of novel diazenes bearing pyrrole, thiophene and thiazole heterocycles as efficient photochromic and nonlinear optical (NLO) materials显示文摘 | M. Manuela M. Raposo A. Maurício C. Fonseca M. Cidália R. Castro M. Belsley M. Fátima S. Cardoso Luís M. Carvalho Paulo J. Coelho | 2011 | Dyes and Pigments2011，，1： | 1 |
| 18 | The influence of growth mode on quality of GaN films and blue LEDwafers grown by MOCVD显示文摘 | Lia S T Jiangb F Y Fana G H | 2007 | Physica B2007，391，1： | 1 |
| 19 | Physiologica,anatomical and biomass partitioning responses to ozone in the Mediterranean endemic plant Lamottea dianae显示文摘 | Calatayud V García-Breijo F J Júlia C | 2011 | Ecotoxicology and Environmental Safety2011，74，： | 1 |
| 20 | Inactivation of Saccharomyces cerevisiae by supercritical and subcritical carbon dioxide显示文摘 | Lia H M Yang Z Y Chen L F | 1992 | Biotechnology Progress1992，8，5： | 1 |
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