|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling显示文摘Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury,but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes(CMs) for driving the differentiation of cardiac stem cells(CSCs).Forced hypoxia-inducible factor 1α(HIF-1α) expression and physical hypoxia(5% O_2) treatment could induce Jagged1 expression in neonatal rat CMs. Pharmacological inhibition of HIF-1α by YC-1 attenuated hypoxia-promoted Jagged1 expression in CMs. An ERK inhibitor(PD98059), but not inhibitors of JNK(SP600125), Notch(DAPT), NF-κB(PTDC), JAK(AG490), or STAT3(Stattic) suppressed hypoxiainduced Jagged1 protein expression in CMs. c-Kit^+ CSCs isolated from neonatal rat hearts using a magnetic-activated cell sorting method expressed GATA4, SM22α or vWF, but not Nkx2.5 and cTnI.Moreover, 87.3% of freshly isolated CSCs displayed Notch1 receptor expression. Direct co-culture of CMs with BrdU-labeled CSCs enhanced CSCs differentiation, as evidenced by an increased number of BrdU^+/Nkx2.5^+ cells, while intermittent hypoxia for 21 days promoted co-culture-triggered differentiation of CSCs into CM-like cells. Notably, YC-1 and DAPT attenuated hypoxia-induced differentiation.Our results suggest that hypoxia induces Jagged1 expression in CMs primarily through ERK signaling,and facilitates early cardiac lineage differentiation of CSCs in CM/CSC co-cultures via HIF-1α/Jagged1/Notch signaling. | Keke Wang Ranran Ding Yanping Ha Yanan Jia Xiaomin Liao Sisi Wang Rujia Li Zhihua Shen Hui Xiong Junli Guo Wei Jie | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 7 |
| 2 | Human leukocyte antigen-G in ankylosiug spondylitis and the response after tumour necrosis factor-alphablocker therapy显示文摘 | Chen CH Liao HT Chen HA | 2010 | Rheumatology ( Oxford)2010，49，2： | 1 |
| 3 | Clinical,functional,and radiographic differences among juvenile-onset,adult-onset,and late-onset ankylosing spondylitis显示文摘 | Chen HA Chen CH Liao HT | | 0，，05： | 1 |
| 4 | Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss 显示文摘 | PAIGE J A LIAO R L HA J JAR R J | 1996 | Cardiovascular Research1996，31，2： | 1 |
| 5 | Factors associated withradiographic spinal involvement and hip involvement in ankylosingspondylitis显示文摘 | Chen HA Chen CH Liao HT | 2011 | Semin Arthritis Rheum2011，40，6： | 1 |
| 6 | Arterial stiffness and the development of hypertension The Atherosclerosis Risk in Communities(ARIC)study显示文摘 | Liao D Amett DK Tyroler HA | 1999 | Hypertension1999，34，2： | 1 |
| 7 | Undifferentiated spondyloarthropathy in Chinese patients 显示文摘 | Liao HT Chen HA Chen CH | 2006 | Arch Med Res2006，37，3： | 1 |
| 8 | Soluble receptor activator of nuclear factor-kappaB ligand(RANKL)and osteoprotegerin in an- kylosing spondylitis:OPG is associated with poor physical mobility and reflects systemic inflammation 显示文摘 | Chen CH Chen HA Liao HT | 2010 | Clin Rheumatol2010，29，10： | 1 |
| 9 | Arterial stiffness and the development of hypertension显示文摘 | Arnett DK Tyroler HA | 1999 | The ARIC Study Hypertension1999，34，： | 1 |
| 10 | Phylodynamic analysis of the dissemination of HIV-1 CRF01_AE in Vietnam 显示文摘 | Liao HA Tee KK Hase S | 2009 | Virology2009，391，1： | 1 |
| 11 | Perfluorinated compound levels in cord blood and neurodevelopment at2yearsofage显示文摘 | Chen MH Ha EH Liao HF | 2013 | Epidemiology2013，24，6： | 1 |
| 12 | A arterial stiffness and the development of hypertension:the ARIC Study显示文摘 | Liao D Armett DK Tyroler HA | 1999 | Hypertension1999，30，5： | 1 |
| 13 | Soluble receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in ankylosing spondylitis:OPG is associated with poor physical mobility and reflects systemic inflammation 显示文摘 | Chen CH Chen HA Liao HT | 2010 | Clin Rhoumatol2010，29，10： | 1 |
| 14 | Arterial stiffness and the development of hypertension the ARIC study显示文摘 | Liao D Arnett DK Tyroler HA | 1999 | Hypertension1999，34，2： | 1 |
| 15 | Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme a reductase inhibitor is mediated by endothelial nitric oxide synthase显示文摘 | Wolfrum S Grimm M Heidbreder M Dendorfer A Katus HA Liao JK | 2003 | J Cardiovasc Pharmacol2003，41，： | 1 |
| 16 | Perfluorinated compound levels in cord blood and neurodevelopment at 2 years of age 显示文摘 | Chert M Ha E Liao H | 2013 | Epidemiology2013，24，6： | 1 |
| 17 | Mantle irradiation alone for pathologic stage Ⅰ and Ⅱ Hodrkin's disease: long - term follow - up and patterns of failure 显示文摘 | LIAO Z HA C S VLACHAKI M T | 2001 | Int J Radiat Oncol Biol Phys2001，50，： | 1 |
| 18 | Soluble receptor acti- vator of nuclear factor-kappaB ligand (RANKL) and os- teoprotegerin in ankylosing spondylitis: OPG is associated with poor physical mobility and reflects systemic inflammation显示文摘 | Chen CH Chen HA Liao HT | 2010 | Clin Rheumatol2010，29，10： | 1 |
| 19 | Undifferentiated spondyloarthropathy in Chinese patients显示文摘 | Liao HT Chen HA Chen CH | 2006 | Arch Med Res2006，37，3： | 1 |
| 20 | Soluble receptor activator of nuclear factor - kappaB ligand (RANKL) and osteoprotegerin in an- kylosing spondylitis: OPG is associated with poor physical mobility and reflects systemic inflammation 显示文摘 | Chen CH Chen HA Liao HT | 2010 | Clin Rheumatol2010，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员