| 1 | Natural co-infection of fowl adenovirus type E-8b and avian hepatitis E virus in parental layer breeders in Hebei,China显示文摘Dear Editor,Fowl adenovirus(FAdV)and avian hepatitis E virus(aHEV)are the most important causative agents of hepatic injury,representing one of the greatest health concerns in layer chicken flocks(LCFs)in China and causes substantial economic losses.FAdVs are non-enveloped,double-stranded DNA viruses containing a genome of 43–45 kb in size and belong to the genus Aviadenovirus in the family of Adenoviridae(Hess,2000).Based on restriction enzyme digestion patterns and serum cross-neutralization tests,FAdV is currently clustered into five species(FAdV-A–FAdV-E)with 12 serotypes(FAdV-1 to-7,FAdV-8a,FAdV-8b,and FAdV-9 to-11).Different serotypes of FAdVs cause different clinical symptoms in poultry flocks.FAdV-1 can induce gizzard erosion in chickens,whereas inclusion body hepatitis(IBH)in chickens is often associated with FAdV-2,-8a,-8b,and-11.FAdV-4 causes hydropericardium hepatitis syndrome and IBH in chickens,and its infections have caused severe economic losses in the global poultry industry(Ye et al.,2016).Avian hepatitis E virus(aHEV)is a major causative agent of big liver and spleen disease(BLS),hepatitis splenomegaly syndrome,and hepatic rupture hemorrhage syndrome(HRHS)in chickens(Sun et al.,2019). | Lidan Hou Zengna Chi Yawen Zhang Qi Xue Tianshu Zhai Shuang Chang Jia Wang Peng Zhao | 2023 | Virologica Sinica2023，38，2： | 0 |
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