5篇
您的检索式：作者名="Lieve Umans"
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| 1 | The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation显示文摘 | Ramya Rajagopal Jie Huang Lisa K. Dattilo Vesa Kaartinen Yuji Mishina Chu-Xia Deng Lieve Umans An Zwijsen Anita B. Roberts David C. Beebe | 2009 | Developmental Biology2009，，2： | 1 |
| 2 | α2-Macroglobulin- and Murinoglobulin-1- Deficient Mice显示文摘 | Lieve Umans Lutgarde Serneels Lut Overbergh Lou Stas Fred Van Leuven | 1999 | The American Journal of Pathology1999，，3： | 1 |
| 3 | Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades显示文摘 | Iván M. Moya Lieve Umans Elke Maas Paulo N.G. Pereira Karen Beets Annick Francis Ward Sents Elizabeth J. Robertson Christine L. Mummery Danny Huylebroeck An Zwijsen | 2012 | Developmental Cell2012，，3： | 1 |
| 4 | Robustness in angiogenesis: Notch and BMP shaping waves显示文摘 | Karen Beets Danny Huylebroeck Iván M. Moya Lieve Umans An Zwijsen | 2012 | Trends in Genetics2012，，： | 1 |
| 5 | Smad1/5/8 are myogenic regulators of murine and human mesoangioblasts显示文摘Mesoangioblasts(MABs)are vessel-associated stem cells that express pericyte marker genes and participate in skeletal muscle regeneration.Molecular circuits that regulate the myogenic commitment of MABs are still poorly characterized.The critical role of bone morphogenetic protein(BMP)signalling during proliferation and differentiation of adult myogenic precursors,such as satellite cells,has recently been established.Weevaluated whether BMP signalling impacts on the myogenic potential of embryonic and adult MABs both in vitro and in vivo.Addition of BMP inhibited MAB myogenic differentiation,whereas interference with the interactions between BMPs and receptor complexes induced differentiation.Similarly,siRNA-mediated knockdown of Smad8 in Smad1/5-null MABs or inhibition of SMAD1/5/8 phosphorylation with Dorsomorphin(DM)also improved myogenic differentiation,demonstrating a novel role of SMAD8.Moreover,using a transgenic mouse model of Smad8 deletion,we demonstrated that the absence of SMAD8 protein improved MAB myogenic differentiation.Furthermore,once injected into a-Sarcoglycan(Sgca)-null muscles,DM-treated MABs were more efficacious to restore a-sarcoglycan(aSG)protein levels and re-establish functional muscle properties.Similarly,in acute muscle damage,DM-treated MABs displayed a better myogenic potential compared with BMP-treated and untreated cells.Finally,SMADs also control the myogenic commitment of human MABs(hMABs).BMP signalling antagonists are therefore novel candidates to improve the therapeutic effects of hMABs. | Domiziana Costamagna Mattia Quattrocelli Florence van Tienen Lieve Umans Irineus FMde Coo An Zwijsen Danny Huylebroeck Maurilio Sampaolesi | 2016 | Journal of Molecular Cell Biology2016，8，1： | 0 |
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