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| 1 | Regulation of glucose and lipid metabolism in health and disease显示文摘Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the most abundant sterol in mammals, is a key component of cell membranes although it does not generate ATP. The metabolisms of glucose, fatty acids and cholesterol are often intertwined and regulated. For example, glucose can be converted to fatty acids and cholesterol through de novo lipid biosynthesis pathways. Excessive lipids are secreted in lipoproteins or stored in lipid droplets. The metabolites of glucose and lipids are dynamically transported intercellularly and intracellularly, and then converted to other molecules in specific compartments. The disorders of glucose and lipid metabolism result in severe diseases including cardiovascular disease, diabetes and fatty liver. This review summarizes the major metabolic aspects of glucose and lipid, and their regulations in the context of physiology and diseases. | Ligong Chen Xiao-Wei Chen Xun Huang Bao-Liang Song Yan Wang Yiguo Wang | 2019 | Science China(Life Sciences)2019，62，11： | 40 |
| 2 | The SLC transporter in nutrient and metabolic sensing, regulation, and drug development显示文摘The prevalence of metabolic diseases is growing worldwide. Accumulating evidence suggests that solute carrier (SLC) transporters contribute to the etiology of various metabolic diseases. Consistent with metabolic characteristics, the top five organs in which SLC transporters are highly expressed are the kidney, brain, liver, gut, and heart. We aim to understand the molecular mechanisms of important SLC transporter-mediated physiological processes and their potentials as drug targets. SLC transporters serve as Metabolic gate’ of cells and mediate the transport of a wide range of essential nutrients and metabolites such as glucose, amino acids, vitamins, neurotransmitters, and inorganic/metal ions. Gene-modified animal models have demonstrated that SLC transporters participate in many important physiological functions including nutrient supply, metabolic transformation, energy homeostasis, tissue development, oxidative stress, host defense, and neurological regulation. Furthermore, the human genomic studies have identified that SLC transporters are susceptible or causative genes in various diseases like cancer, metabolic disease, cardiovascular disease, immunological disorders, and neurological dysfunction? Importantly, a number of SLC transporters have been successfully targeted for drug developments。 This review will focus on the current understanding of SLCs in regulating physiology, nutrient sensing and uptake, and risk of diseases. | Yong Zhang Yuping Zhang Kun Sun Ziyi Meng Ligong Chen | 2019 | Journal of Molecular Cell Biology2019，11，1： | 11 |
| 3 | Memory T cells: strategies for optimizing tumor immunotherapy显示文摘Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells.Furthermore,the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors.Thus,a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors.This review focuses on recent advances in efficacy against tumors,the origin,formation mechanisms of memory T cells,and the role of the gut microbiota in memory T cell formation.Furthermore,we summarize strategies to generate memory T cells in (ex) vivo that,might be applicable in clinical practice. | Qingjun Liu Zhongjie Sun Ligong Chen | 2020 | Protein & Cell2020，11，8： | 10 |
| 4 | Synthesis and Application of Novel Triazine-Based Charring-Foaming Agents in Intumescent Flame Retardant Polypropylene显示文摘Three novel triazine-based charring-foaming agents (M2-CFA,M4-CFA,and M6-CFA) were synthesized successfully with only water as the solvent and were characterized by FT-IR and thermal gravimetric analysis (TGA).These three charring-foaming agents and the byproduct 944-by were employed to study the effectiveness of the novel intumescent flame retardant dopant on the fire retardancy of polypropylene (PP) investigated through UL-94 and limiting oxygen index (LOI) tests.TGA results showed that the M4-CFA presented good char formation ability (char residue: 26.8% at 700 ℃).It was found that the sample with a 2/1 mass ratio of APP to M4-CFA exhibited the best flame retardancy among all the PP composites: 35.5% LOI and a V-0 rating of UL-94.Additionally,the microstructure and morphology of char residues were further studied by XRD,Raman spectroscopy and SEM. | Ligong Chen Yanyan Yuan Bowei Wang Na Liu Yuzhi Xing Yang Li | 2017 | Transactions of Tianjin University2017，23，3： | 9 |
| 5 | All-optical 2R regeneration based on self-induced polarization rotation in a single semiconductor optical amplifier显示文摘An all-optical 2R regeneration based on self-induced polarization rotation in a single semiconductor optical amplifier is presented.A theoretical model is built up to simulate the system performance.Experiment evidence is also provided.An extinction ratio improvement of 8.3 dB is obtained at a bitrate of 10 Gbit/s.In the BER measurements,6 dB improvement of the power penalty is achieved,clearly demonstrating the feasibility of the proposed scheme.Our approach has a simple structure,and allows photonic integration. | DUAN PinXiang CHEN LiGong ZHANG ShangJian ZHOU XiaoLi LIU YongZhi LIU Yong | 2009 | Chinese Science Bulletin2009，54，20： | 7 |
| 6 | The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2显示文摘Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions. | Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang | 2019 | Protein & Cell2019，10，6： | 6 |
| 7 | The solute carrier transporters and the brain:Physiological and pharmacological implications显示文摘Solute carriers(SLCs)are the largest family of transmembrane transporters that determine the exchange of various substances,including nutrients,ions,metabolites,and drugs across biological membranes.To date,the presence of about 287 SLC genes have been identified in the brain,among which mutations or the resultant dysfunctions of 71 SLC genes have been reported to be correlated with human brain disorders.Although increasing interest in SLCs have focused on drug development,SLCs are currently still under-explored as drug targets,especially in the brain.We summarize the main substrates and functions of SLCs that are expressed in the brain,with an emphasis on selected SLCs that are important physiologically,pathologically,and pharmacologically in the blood-brain barrier,astrocytes,and neurons.Evidence suggests that a fraction of SLCs are regulated along with the occurrences of brain disorders,among which epilepsy,neurodegenerative diseases,and autism are representative.Given the review of SLCs involved in the onset and procession of brain disorders,we hope these SLCs will be screened as promising drug targets to improve drug delivery to the brain. | Chengliang Hu Lei Tao Xizhi Cao Ligong Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 6 |
| 8 | The physiological role of drug transporters显示文摘Transporters 在人的有机体包括膜蛋白质的最大的家庭,包括溶质搬运人 transporter 和 ATP 有约束力的盒子 transporter 家庭的成员。他们在 xenobiotic 和内长的分子的吸收,分发和排泄起枢轴的作用。Transporters 广泛地在各种各样的人的纸巾被表示并且习惯性地在药开发和赞同的过程期间被评估。在过去的十年,增加证据证明药 transporters 在正常生理学和疾病是重要的。当前, transporters 作为治疗学的目标被利用治疗象糖尿病,主要消沉,高血压和便秘那样的众多的疾病。尽管有 transporter 生物学的地的稳定的生长,多于成员在的一半 ? transporter 总科几乎没有关于他们的内长的底层或生理的功能可得到的很少信息。这评论在 transporter 研究构画出当前的研究方法,并且包括药药和药内长的底层相互作用总结药运输相互作用。最后,我们 ? 也讨论 transporters 的治疗学的观点基于他们的生理并且 pathophysiological 角色。 | Yu Liang Siqi Li Ligong Chen | 2015 | Protein & Cell2015，6，5： | 5 |
| 9 | Improved Photovoltaic Performance of MEH-PPV/PCBM Solar Cells via Incorporation of Si Nanocrystals显示文摘当器官的体积异质接面太阳能电池的性能上的第三个部件创作了,我们学习了硅 nanocrystals (SiNCs ) 的效果 poly [2-methoxy,5-(2-ethylhexyloxy )-1,4-phenylene vinylene ](MEH-PPV ):[6,6 ]-phenyl-C61-butyric 酸甲基酉旨(PCBM ) 混合电影。由增加 SiNCs 的合适的数量进 MEH-PPV : PCBM 混合,象外部量效率那样的设备表演,短路电流密度(JSC ) ,和功率变换效率(PCE ) 改善了。在混合的 2.5% SiNCs 的加入导致了 JSC 的 13.6% 改进,它接着导致了 PCE 的 18% 改进直到 2.28% 。改进表演在阴极在从 MEH-PPV/SiNCs 和费用收集的接口的费用产生两个都主要由于改进。 | Quanxiang Yan Lijian Zuo Zhuowei Gu Ligong Yang Rong Wang Mang Wang Hongzheng Chen | 2013 | Chinese Journal of Chemistry2013，31，11： | 2 |
| 10 | A continuous process for the synthesis of homopiperazine catalyzed by Cu-based catalysts 显示文摘 | Wang Hefang Chen Ligong Luan Dezhi | 2006 | Reaction Kinetics and Catalysis Letters2006，，2： | 1 |
| 11 | Selective synthesis of cis-2,6-dimethylpiperazine catalyzed by a Cu-Cr-Fe /γ-Al2O3 catalyst显示文摘 | Guoyi BAI Ligong CHEN Yang LI | 2004 | Appl Catal A2004，277，12： | 1 |
| 12 | Improving welded valve quality by vibratory weld conditioning 显示文摘 | Qinghua Lu Ligong Chen Chunzhen Ni | 2007 | Materials Science and Engineering: A2007，457，12： | 1 |
| 13 | Calcined Mg- Al hydrotalcites as solid base catalysts for methanolysis of soybean oil 显示文摘 | Wenlei Xie Hong Peng Ligong Chen | 2006 | Journal of Molecular Catalysis A: Chemical2006，246，： | 1 |
| 14 | Transesterification of soybean oil catalyzed by potassium loaded on alumina as a ,solid-base catalyst 显示文摘 | Xie Wenlei Peng neng Chen Ligong | 2006 | Applied Catalysis A: General2006，300，： | 1 |
| 15 | Regeneration of waste lubricant oil by extraction-flocculation composite refining显示文摘 | Yang Xin Chen Ligong Xiang Shuo | 2013 | Ind Eng Chem Res2013，52，12： | 1 |
| 16 | Modeling and estimating for external characteristic of welding power source显示文摘 | Zhu Zhengqiang Chen Ligong Xu Jianning | 2006 | International Journal of Advanced Manufacturing Technology2006，，29： | 1 |
| 17 | Newcastle disease in geese: natural occurrence and experimental infection显示文摘 | Wan Hongquan Chen Ligong Wu Lili | 2004 | Avian Pathol2004，33，2： | 1 |
| 18 | Calcined Mg-Al hydrotalcites as solid base catalysts for methanolysis of soybean oil显示文摘 | Wenlei Xie Hong Peng Ligong Chen | 2006 | Journal of Molecular Catalysis A:Chemical2006，246，12： | 1 |
| 19 | Transesterification of soybean oil catalyzed by potassium loaded on alumina as a solid-base catalyst显示文摘 | Wenlei Xie Hong Peng Ligong Chen | 2006 | Applied Catalysis A:General2006，300，1： | 1 |
| 20 | Transesterification of soybean oil catalyzed by potassium loaded on alumina as a solid-base catalyst显示文摘 | Xie Wenlei Peng Hong Chen Ligong | 2006 | Appl Catal A-Gen2006，300，1： | 1 |
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