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| 1 | Comparison of breast-conserving surgery and mastectomy in early breast cancer using observational data revisited:a propensity score-matched analysis显示文摘Recent observational studies showed that breast-conserving surgery(BCS) resulted in superior survival compared to mastectomy in breast cancer patients. This study compared the clinical outcomes of BCS and mastectomy using propensity score(PS)matching analysis, which had advantages over conventional methods in reducing bias. Nonmetastatic breast cancer patients who underwent BCS and mastectomy were matched 1:1 based on their PS. We used the Kaplan-Meier method and Cox-regression model to estimate the treatment effects. A total of 2,866 patients with a median follow-up time of 67 months were included in the original study population. Although the mastectomy cohort(N=1,219) had more advanced disease compared to the BCS cohort(N=1,647), LRFS was similar between the two groups(93.8% vs. 92.4%, P>0.05). BCS(vs. mastectomy) was associated with improved DFS(73.8% vs. 58.7%, P<0.01) and CSS(91% vs. 78.2%, P<0.01) in the original population. In the PS-matched population(N=1,668), clinicopathological features were equally distributed between the two cohorts. BCS(vs. mastectomy) was not associated with improved DFS(70.7% vs. 66.9%, P>0.05) or CSS(87.5% vs. 84.9%, P>0.05). We found that PS methods reduce bias when estimating treatment effects using observational data. BCS and mastectomy show equivalent outcomes in nonmetastatic breast cancer patients. | Kai Chen Zihao Pan Liling Zhu Tingting Hu Min Peng Weijuan Jia Fengxi Su Shunrong Li Erwei Song | 2018 | Science China(Life Sciences)2018，61，12： | 12 |
| 2 | Carbon Sequestration Effects of Shrublands in Three-North Shelterbelt Forest Region, China显示文摘三北方的防风林福雷斯特(TSF ) 节目,是六个关键林地节目之一并且有一个 73 年的构造时期,从 1978 ~ 2050。在这个区域的灌木的碳隐遁的定量分析为在中国理解森林和另外的陆上的生态系统的碳隐遁的全面功能是重要的。这研究在 1978 和 2008 基于遥感图象在 TSF 区域调查了 shrubland 的分发区域,并且从出版报纸与领域调查和以前的数据在联合计算了 shrubland 的碳密度。从 1978 ~ 2008 的碳隐遁数量和率在 TSF 区域为四个分区和灌木的不同类型被分析。结果揭示了那:1 ) 在学习区域和它的四个分区的 shrubland 的区域在过去的三十年期间增加了。为在 2008 的整个区域的 shrubland 的区域是为 25 恢复了年的 1.2 tation。实验在 Yanan 城市里在 Yangjuangou 集水被进行, Shaanxi 省,中国。二个邻近的斜坡为这研究被选择。六个样品地点是 spaced 到沿着山斜坡的脚趾斜坡的从顶点的每 3545 m,和每个样品地点包含了三个采样阴谋。土壤在表面土壤层( 010 厘米和 1020 厘米)的器官的碳和相关物理化学的性质基于土壤采样和实验室分析被测量,并且土壤二氧化碳(公司<潜水艇class=“ a-plus-plus ”> 2 )排出物和环境因素同时在一样的样品地点被测量。结果显示一般来说,一张更高的土壤碳股票被发现在里面吗? | LIU Wenhui ZHU Jiaojun JIA Quanquan ZHENG Xiao LI Junsheng LOU Xuedong HU Lile | 2014 | Chinese Geographical Science2014，24，4： | 11 |
| 3 | Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner显示文摘Clustered protocadherins(Pcdhs)are a large family of cadherin-like cell adhesion proteins that are central for neurite selfavoidance and neuronal connectivity in the brain.Their downstream nonreceptor tyrosine kinase Pyk2(proline-rich tyrosine kinase 2,also known as Ptk2b,Cakb,Raftk,Fak2,and Cadtk)is predominantly expressed in the hippocampus.We constructed Pyk2-null mouse lines and found that these mutant mice showed enhancement in contextual fear memory,without significant change in auditory-cued and spatial-referenced learning and memory.In addition,by preparing Y402F mutant mice,we observed that Pyk2 suppressed contextual fear memory in an autophosphorylation-independent manner.Moreover,using high-throughput RNA sequencing,we found that immediate early genes,such as Npas4,cFos,Zif268/Egr1,Arc,and Nr4a1,were enhanced in Pyk2-null mice.We further showed that Pyk2 disruption affected pyramidal neuronal complexity and spine dynamics.Thus,we demonstrated that Pyk2 is a novel fear memory suppressor molecule and Pyk2-null mice provide a model for understanding fearrelated disorders.These findings have interesting implications regarding dysregulation of the Pcdh–Pyk2 axis in neuropsychiatric disorders. | Jin Zheng Lun Suo Yuxiao Zhou Liling Jia Jingwei Li Yanping Kuang Donghong Cui Xuehong Zhang Qiang Wu | 2021 | Journal of Molecular Cell Biology2021，13，11： | 0 |
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