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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Frequency of mental disturbances in HTLV - 1 patients in the state of Bahia, Brazil 显示文摘 | Carvalho AG Galvao - Phileto AV Lima NS | 2009 | Braz J Infect Dis2009，13，1： | 1 |
| 3 | The effect of the orientation of the aeetabular and femoral components on the range of motion of the hip at different head-neck ratios显示文摘 | D'Lima Urquhart AG Buehler KO | 2000 | J Bone Joint Surg Am2000，82，： | 1 |
| 4 | Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis显示文摘 | Lima AG Antequera R Peres MP | 2010 | Braz Dent J2010，21，3： | 1 |
| 5 | Prevalence and prognostic value of perfusion defects detected by stress technetium-99m sestamibi myocardial perfusion single-photon emission cmputed tomography in asymptomatic patients with diabetes mellitus and no known coronary artery disease显示文摘 | De Lorenzo A Lima RS Siqueira-Filho AG Pantoja MR | 2002 | Am J Cardiol2002，90，： | 1 |
| 6 | The effect of the orientation of the acetabular and femoral components on therange of motion of the hip at different head-neck ratios 显示文摘 | D'Lima DD Urquhart AG Buehler KO | 2000 | J Bone Joint Surg [Am]2000，82，3： | 1 |
| 7 | Tibiofemoral conformity and kinematics of rotating-bearing knee prostheses显示文摘 | D'Lima DD Trice M Urquhart AG | 2001 | Clin Orthop Relat Res2001，87，386： | 1 |
| 8 | Intracerebroventricu- lar physostigmine facilitates heat loss mechanisms in running rats 显示文摘 | Rodrigues AG Lima NRV Coimbra CC | 2004 | J Appl Physiol2004，97，1： | 1 |
| 9 | The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratios显示文摘 | D'Lima DD Urquhart AG Buehler KO | 2000 | J Bone Joint Surg(Am)2000，82，11： | 1 |
| 10 | Evidence that exercise-induced heat storage is dependent on adrenomedullary secretion显示文摘 | Rodrigues AG Lima NR Coimbra CC | | 0，，03： | 1 |
| 11 | The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratios显示文摘 | D’Lima DD Urquhart AG Buehler KO | | 0，，03： | 1 |
| 12 | Tibiofemoral conformity and kinematics of rotating-bearing knee prostheses显示文摘 | Lima DD Trice M Urqhuhart AG | 2001 | Clin Orthop2001，386，： | 1 |
| 13 | Tibiofemoral conformity and kinematics of rotating-bearing knee prostheses显示文摘 | D'Lima DD Trice M Urquhart AG | | 0，，386： | 1 |
| 14 | Tibiofemoral conformity and kinematics of rotating-bearing knee prostheses显示文摘 | D'Lima DD Trice M Urquhart AG | 2001 | Clin Orthop Relat Res2001，，386： | 1 |
| 15 | The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratios显示文摘 | D'Lima DD Urquhart AG Buehler KO | | 0，，03： | 1 |
| 16 | Tibio femoral conformity and kinematics of rotating-bearing knee prostheses显示文摘 | Lima DD Trice M Urqhuhart AG | | 0，，： | 1 |
| 17 | Tibiofemoral conformity and kinematics of rotating-bearing knee prostheses显示文摘 | D'Lima DD Trice M Urquhart AG | 2001 | Clin Orthop Relat Res2001，386，： | 1 |
| 18 | Clinicobiological, immunophenotypic, and molecular characteristics of monoclonal CD56 - / + dim chronic natural killer cell large granular lymphocytosis 显示文摘 | Lima M Almeida J Montero AG | 2004 | Am J Pathol2004，165，4： | 1 |
| 19 | Efficacy of low level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy induced oral mucositis显示文摘 | Lima AG Antequera R Peres MP | 2010 | Braz Dent J2010，21，3： | 1 |
| 20 | The effect of the orientation of the acetabular and femoral components on the range of motion of the hip at different head-neck ratios显示文摘 | D'Lima DD Urquhart AG Buehler KO | 2000 | J Bone Joint Surg(Am)2000，82，： | 1 |
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