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| 1 | The role of m6A modification in the biological functions and diseases显示文摘N6-methyladenosine(m6A)is the most prevalent,abundant and conserved internal cotranscriptional modification in eukaryotic RNAs,especially within higher eukaryotic cells.m6A modification is modified by the m6A methyltransferases,or writers,such as METTL3/14/16,RBM15/15B,ZC3H3,VIRMA,CBLL1,WTAP,and KIAA1429,and,removed by the demethylases,or erasers,including FTO and ALKBH5.It is recognized by m6A-binding proteins YTHDF1/2/3,YTHDC1/2 IGF2BP1/2/3 and HNRNPA2B1,also known as'readers'.Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions,especially in the initiation and progression of different types of human cancers.In this review,we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic,central nervous and reproductive systems.We will mainly focus on recent progress in identifying the biological functions and the underlying molecular mechanisms of m6A RNA methylation,its regulators and downstream target genes,during cancer progression in above systems.We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future. | Xiulin Jiang Baiyang Liu Zhi Nie Lincan Duan Qiuxia Xiong Zhixian Jin Cuiping Yang Yongbin Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 2 | Serum spleen tyrosine kinase and vascular endothelial growth factor-C levels predict lymph node metastasis of oesophageal squamous cell carcinoma显示文摘 | Lincan Duan Lianhua Ye Guangqiang Zhao Zhengwei Wu Congguo Jin Xinyi Cai Gaofeng Li | 2013 | European Journal of Cardio-Thoracic Surgery2013，，： | 1 |
| 3 | Evaluation of garlic intercropping for enhancing the biological control of Ralstonia solanacearum in flue-cured tobacco fields显示文摘 | Rongquan Lai Minsheng You Lincan Jiang | 2011 | Biocontrol Science & Technology2011，21，7： | 1 |
| 4 | MeasurementofPositioningAccuracyforNC & CNC Machine Toolsand ComparisonandDiscussionoftheThreeDeterminationMethods显示文摘 | LinCan | 1996 | ModernMeasurementandTesting1996，，1： | 1 |
| 5 | Ellipsis in the English Language显示文摘Elliptical sentences are common in the English language, especially in oral English, in dialogue.A good knowledge of elliptical sentences will help a lot when we communicate with the native speakers.Hence, a good mastery of elliptical sentences is of vital significance to communicative effectiveness and fluency. | Lu Yunzhou (English Department, Lincan Education College Lincan Yunnan 677000) | 2002 | 临沧教育学院学报2002，11，1： | 1 |
| 6 | Management of cutaneous B-cell lymphoma:recommemdations of the French cutaneous lymphoma study group显示文摘 | Grange F D 'lincan M Ortonne N | 2010 | Ann dermatol Venerol2010，137，89： | 1 |
| 7 | The U.S.Motives in Initiating Section 301 Investigation against China显示文摘U.S.President Trump signed a memorandum on August 14,2017,authorizing the U.S.trade representative Robert Lighthizer to“look into Chinese trade practices”and determine whether to initiate the Section 301 investigation on China,in order to implement“fair and equitable”trade rules. | Xie Lincan | 2018 | China Economic Transition2018，1，1： | 0 |
| 8 | 肺癌患者外周血血小板活化标志物水平及其临床意义(英文)显示文摘Objective: To investigate the relationship between the activation markers of platelets and the lung cancer. Meth- ods: Based on international stages of lung cancer in 1997, lung cancer patients of 120 cases diagnosed by pathology as well as with operation indication were selected as the experimental group. During the process of experiment, 60 cases concluded as healthy in the physical examination were chosen as control group. The activation markers of platelets were detected by FCM method. The experimental result would be processed by SPSS 11.5. Results: The level of activation markers of platelets in peripheral blood of lung cancer patients was significantly higher than those healthy people (P < 0.01). The level of activation markers of platelets in peripheral blood of lung cancer patients on the seventh postoperative day was significantly lower than that before operation and on the first postoperative day (P < 0.01). The level of activation markers of platelets in peripheral blood of lung cancer patients was closely related to the size of the primary tumor, lymph node status and stages, but not to the grade of cell differentiation, type of tumor, age, sex of the patients (P > 0.05). Conclusion: Elevation of the level of activation markers of platelets in peripheral blood exists in lung cancer patients and the levels of activation marker of platelets plays an important role in tumor growth and lymphatic metastasis. The levels of activation markers of platelets maybe a predictor for prognosis. | Yong Zhang Lincan Duan Xudong Xiang Yunchao Huang Kebao Qian Yongxin Jiang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 0 |
| 9 | Assessing risk of Bombali virus spillover to humans by mutagenesis analysis of viral glycoprotein显示文摘Ebolaviruses,such as the highly pathogenic Ebola virus(EBOV),belong to the family Filoviridae and have caused out-breaks of severe and fatal hemorrhagic fever over the past years.Bombali virus(BOMV)is a newly discovered ebolavirus from bats with unknown potential to infect humans.For most ebolaviruses,the interaction between viral glycoprotein(GP)and host receptor Niemann-Pick C1(NPC1)is crucial for viral entry and determines host tropism.Here,we analyzed the BOMV GP-mediated virus entry into human cells using our recently developed EBOV transcription-and replication-competent virus-like particle(trVLP)system.We demonstrated that while BOMV GP can be efficiently incorporated into trVLPs,it is inefficient in mediating trVLP entry into human cells.However,BOMV GP-mediated virus entry into human cells can be significantly enhanced by a few mutations in the NPC1-binding domain of GP.Furthermore,we showed that these mutations increase the binding of BOMV-GP to human NPC1.In summary,our results suggested that although wild-type BOMV does not efficiently infect human cells,the emergence of mutations in viral GP may boost its ability to spill over to humans,highlighting the importance of monitoring BOMV GP evolution in preventing potential BOMV spillover events. | Lincan Li Tianyu Gan Ziyue Ma Yi Huang Jin Zhong | 2024 | hLife2024，2，1： | 0 |
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