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| 1 | Microbiota transplantation reveals beneficial impact of berberine on hepatotoxicity by improving gut homeostasis显示文摘Berberine has been shown to reduce acute liver injury although the underlying mechanism is not fully understood. Because of the anatomic connection, the liver is constantly exposed to gut-derived bacterial products and metabolites. In this study, we showed that berberine has beneficial effects on both hepatotoxicity and intestinal damage in a rat model of chronic or acute liver injury. Microbiota transplantation from the rats with chronic hepatotoxicity could aggravate acute hepatotoxicity in mice treated with diethylnitrosamine(DEN). In rat models with gut homeostasis disruption induced by penicillin or dextran sulfate sodium(DSS), their fecal microbiota could also cause an enhanced hepatotoxicity of recipient mice. When treated with berberine,the DSS-induced enteric dysbacteriosis could be mitigated and their fecal bacteria were able to reduce acute hepatotoxicity in recipient mice. This study indicates that berberine could improve intestinal dysbacteriosis, which reduces the hepatotoxicity caused by pathological or pharmacological intervention. Fecal microbiota transplantation might be a useful method to directly explore homeostatic alteration in gut microbiota. | Chenjie Qin Huilu Zhang Linghao Zhao Min Zeng Weijian Huang Gongbo Fu Weiping Zhou Hongyang Wang Hexin Yan | 2018 | Science China(Life Sciences)2018，61，12： | 8 |
| 2 | Biochar Supported Nanoscale Zero-valent Iron Composites for the Removal of Petroleum from Wastewater显示文摘Considering the need for efficiently and rapidly treating oily wastewater while preventing secondary pollution,the nanoscale zero-valent iron(nZVI)was supported on biochar prepared by using a spent mushroom substrate(SMS),to produce an iron-carbon composite(SMS-nZVI).The ability of the SMS-nZVI to treat wastewater containing high concentration of oil was then comprehensively evaluated.The morphology,structure,and other properties of the composite were characterized by using scanning electron microscopy,transmission electron microscopy,the Brunauer-Emmett-Teller nitrogen sorption analysis,and the Fourier transform infrared spectroscopy.The results show that the biochar prepared by using the SMS can effectively prevent the agglomeration of nZVI and increase the overall specific surface area,thereby enhancing the absorption of petroleum by the composite.Experiments reveal that compared with the SMS and nZVI,the SMS-nZVI composite removes petroleum faster and more efficiently from wastewater.Under optimized conditions involving an nZVI to biochar mass ratio of 1:5 and a pH value of 4,the efficiency for removal of petroleum from wastewater with an initial petroleum concentration of 1000 mg/L could reach 95%within 5 h.Based on a natural aging treatment involving exposure to air for 30 d,the SMS-nZVI composite retained an oil removal rate of higher than 62%,and this result could highlight its stability for practical applications. | Qin Feifei Xu Wenfei Hao Boyu Yin Linghao Song Jiayu Zhang Xiuxia | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，4： | 2 |
| 3 | Novel Starch/Chitosan Blending Membrane: Antibacterial, Permeable and Mechanical Properties显示文摘 | Liu Fujun Qin Bing He Linghao | 2009 | Carbohydrate Polymers2009，78，1： | 1 |
| 4 | Novel starch/chitosan blending membrane: Antibacterial,permeable and mechanical properties显示文摘 | LIU Fujun QIN Bing HE Linghao | 2009 | Carbohydrate Polymers2009，78，1： | 1 |
| 5 | Novel starch / chitosan blending membrane : Antibacterial, permeableand mechanical properties 显示文摘 | Liu Fujun Qin Bing He Linghao | 2009 | Carbohydrate Polymers2009，78，： | 1 |
| 6 | Novel starch/chitosanblending membrane:Antibacterial,permeable and mechanicalproperties显示文摘 | Liu Fujun Qin Bing He Linghao | 2009 | Carbohydr Polym2009，78，1： | 1 |
| 7 | Novel starch/chitosan blending membrane: Antibacterial, permeable and mechanical properties 显示文摘 | LIU Fujun QIN Bing HE Linghao | 2009 | Carbohydrate Polymers2009，78，1： | 1 |
| 8 | Novel stare显示文摘 | Fujun Liu Bing Qin Linghao He | 2009 | Carbohydrate polymers2009，78，1： | 1 |
| 9 | Novel starch/chitosan blending membrane: Antibacterial, permeable and mechanical properties 显示文摘 | Fujun Liu Bing Qin Linghao He | 2009 | Carbohydrate Polymers2009，78，： | 1 |
| 10 | Novel starch/chitosan blending membrane:antibacterial,permeable and mechanical properties显示文摘 | LIU Fujun QIN Bing HE Linghao | 2009 | Carbohydrate Polymers2009，78，1： | 1 |
| 11 | A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression显示文摘Metastasis and resistance are main causes to affect the outcome of the current anticancer therapies.Heat shock protein 90(Hsp90)as an ATP-dependent molecular chaperone takes important role in the tumor metastasis and resistance.Targeting Hsp90 and downregulating its expression show promising in inhibiting tumor metastasis and resistance.In this study,a redox-responsive dual-drug nanocarrier was constructed for the effective delivery of a commonly used chemotherapeutic drug PTX,and a COAmodified 4-arm PEG polymer(4PSC)was synthesized.COA,an active component in oleanolic acid that exerts strong antitumor activity by downregulating Hsp90 expression,was used as a structural and functional element to endow 4PSC with redox responsiveness and Hsp90 inhibitory activity.Our results showed that 4PSC/PTX nanomicelles efficiently delivered PTX and COA to tumor locations without inducing systemic toxicity.By blocking the Hsp90 signaling pathway,4PSC significantly enhanced the antitumor effect of PTX,inhibiting tumor proliferation and invasiveness as well as chemotherapy-induced resistance in vitro.Remarkable results were further confirmed in vivo with two preclinical tumor models.These findings demonstrate that the COA-modified 4PSC drug delivery nanosystem provides a potential platform for enhancing the efficacy of chemotherapies. | Yi Zhou Yingling Miao Qiudi Huang Wenwen Shi Jiacui Xie Jiachang Lin Pei Huang Chengfeng Yue Yuan Qin Xiyong Yu He Wang Linghao Qin Jianhai Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
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