|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells显示文摘Homocysteine (Hcy ) 为心血管的事件作为一个流行风险因素被认出了。装载胆固醇的泡沫房间是动脉粥样硬化患者损害的一个中央部件。ATP 有约束力的盒子 transporter A1 (ABCA1 ) 它调停细胞的胆固醇和 phospholipids 的流出,是在类脂化合物的限制率的步新陈代谢。酰辅酶 A:cholesterol acyltransferase-1 (ACAT1 ) 在巨噬细胞支持胆固醇酉旨的累积,从而导致泡沫房间形成,在动脉粥样硬化的早舞台的一个特点。在这研究,有教养的导出单核白血球的泡沫房间为 24 h 与 Hcy 的临床的相关集中被孵化。胆固醇的房间和累积被发现的泡沫的两个都增加的数字,和 ABCA1 的 mRNA 和蛋白质表示层次被减少,当 ACAT1 表示面对 Hcy 被增加时。而且,而 ACAT1 DNA methylation 被使用 Hcy 的不同集中减少, ABCA1 基因的 DNA methylation 水平被增加。而且,我们的结果显示出那项 DNA methyltransferase (DNMT ) 活动和 DNA methyltransferase 1 (DNMT1 ) mRNA 表示被 Hcy 增加。DNA methylation 有功能经由 DNMT 调整 ABCA1 和 ACAT1 的表示,这被显示。在结论,这些结果建议 Hcy 导致的 ABCA1 和 ACAT1 DNA methylation 可以在导出单核白血球的泡沫房间在 ABCA1 和 ACAT1 表示和胆固醇的累积起一个潜在的作用。 | Yu Liang Xiaoling Yang Linna Ma Xin Cai Lei Wang Cheng Yang Guizhong Li Minghao Zhang Weiwei Sun Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 26 |
| 2 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 3 | Evaluating the suitability of TRMM satellite rainfall data for hydrological simulation using a distributed hydrological model in the Weihe River catchment in China显示文摘这研究的目的到份量上评估热带降雨测量有雨计量器数据并且进一步的使命(TRMM ) 数据到使用驱使一个分布式的时间变体获得模型(DTVGM ) 在中国在半潮湿的 Weihe 河集水执行水文学模拟的这个 TRMM 数据。在模拟前,比较与一 10 年(20012010 ) 设置的每日的雨计量器数据表明在每日的时间步, TRMM 降雨数据擅长比降雨极端捕获雨出现和吝啬的值。在每月的时间规模上,在 TRMM 和雨计量器降雨数据之间的好线性关系被发现,与决心系数 R < 啜 class= “ a-plus-plus ” > 为个人在 0.78 和 0.89 之间变化的 2 驻扎。每日的水文学过程上的数据的七年( 20012007 )的随后的模拟结果证实 DTVGM 什么时候由雨计量器数据校准了,比什么时候由 TRMM 数据校准更好表现,但是 TRMM 数据驾驶的模拟的性能比在每月的时间规模上由计量器数据开车的好。结果因此建议 TRMM 降雨数据对在学习的每月的流速及流水量模拟更合适区域,和那当为水平衡部件的刻度和结果的效果也被考虑时, TRMM 3B42-V7 产品有潜力表现很好在类似的盆。 | ZHAO Haigen | 2015 | Journal of Geographical Sciences2015，25，2： | 12 |
| 4 | Accumulation and source of heavy metals in sediment of a reservoir near an industrial park of northwest China显示文摘 | Yuanjie ZHU Xinwei LU Linna YANG Lijun WANG | 2016 | Frontiers of Earth Science2016，10，4： | 11 |
| 5 | Fabrication of submicron barium sulfate aggregates in the presence of ethylenediaminetetraacetic acid anions显示文摘Barium sulfate aggregates with an average size of 0.5 μm were synthesized at pH 7,directed by ethylenediaminetetraacetic acid(EDTA) anions.The particle morphology,chemical composition,and size distribution of the BaSO_4 aggregates were characterized.The as-synthesized BaSO_4 particles were spherical and comprised many interconnected nanoballs,of which the surface properties were affected by the EDTA anions.The adsorption of EDTA anions reversed the charge and weakened the surface polarity of BaSO_4,instigating the formation of aggregates by a self-assembly and transformation process.The resulting BaSO_4 particles at pH 9-10 were ellipsoidal and featured smooth surfaces.Based on the zeta potential of BaSO_4,variations in the morphology induced by changes in pH were closely related to the adsorption of mono- and multi-valent anions onto the electrical double layer of BaSO_4. | Linna Hu Guangxiu Wang Chun Yang Rong Cao | 2015 | Particuology2015，13，5： | 11 |
| 6 | The effect of environmental factors on spatial variability in land use change in the high-sediment region of China's Loess Plateau显示文摘In areas with topographic heterogeneity, land use change is spatially variable and influenced by climate, soil properties, and topography. To better understand this variability in the high-sediment region of the Loess Plateau in which soil loss is most severe and sediment diameter is larger than in other regions of the plateau, this study builds some indicators to identify the characteristics of land use change and then analyze the spatial variability as it is affected by climate, soil property, and topography. We build two indicators, a land use change intensity index and a vegetation change index, to characterize the intensity of land use change, and the degree of vegetation restoration, respectively. Based on a subsection mean method, the two indicators are then used to assess the spatial variability of land use change affected by climatic, edaphic, and topographic elements. The results indicate that: 1) Land use changed significantly in the period 1998–2010. The total area experiencing land use change was 42,302 km2, accounting for 22.57%of the study area. High-coverage grassland, other woodland, and forest increased significantly, while low-coverage grassland and farmland decreased in 2010 compared with 1998. 2) Land use change occurred primarily west of the Yellow River, between 35 and 38 degrees north latitude. The four transformation types, including(a) low-coverage grassland to medium-coverage grassland,(b) medium-coverage grassland to high-coverage grassland,(c) farmland to other woodland, and(d) farmland to medium-coverage grassland, were the primary types of land use change, together constituting 60% of the area experiencing land use change. 3) The spatial variability of land use change was significantly affected by properties of dryness/wetness, soil conditions and slope gradient. In general, land use changed dramatically in semi-arid regions, remained relativelystable in arid regions, changed significantly in clay-rich soil, remained relatively stable in clay-poor soil, changed dramatically in steeper slopes, and remained relatively stable in tablelands and low-lying regions. The increase in vegetation coincided with increasing changes in land use for each physical element. These findings allow for an evaluation of the effect of the Grain to Green Program, and are applicable to the design of soil and water conservation projects on the Loess Plateau of China. | LUO Ya YANG Shengtian ZHAO Changsen LIU Xiaoyan LIU Changming WU Linna ZHAQ Haigen ZHANG Yichi | 2014 | Journal of Geographical Sciences2014，24，5： | 5 |
| 7 | Antioxidant and antiproliferative activities of common edible nut seeds显示文摘 | Jun Yang Rui Hai Liu Linna Halim | 2008 | LWT - Food Science and Technology2008，，1： | 2 |
| 8 | Antioxidant and antiprolif- erative activities of common edible nut seeds显示文摘 | Jun Yang Liu Rui-hai Linna Halim | 2009 | LWT-Food Sci- ence and Technology2009，42，1： | 1 |
| 9 | Research overview of regulations in the Process of Dynamic Mining 显示文摘 | Bingru Yang Wei Song Linna Li el al | 2006 | Journal of Computational Information Systems2006，2，3： | 1 |
| 10 | Extracting drug-drug interaction from the biomedical literature using a stacked generalization-based approach显示文摘 | He Linna Yang Zhihao Zhao Zhehuan | 2013 | Plos One2013，8，65： | 1 |
| 11 | Antioxidant and antiproliferative activities of common edible nut seeds显示文摘 | YANG Jun LIU Ruihai HALIM Linna | 2009 | Lwt-Food Science andTechnology2009，42，1： | 1 |
| 12 | Antioxidant and antiproliferative activities of common edible nut seeds显示文摘 | Jun Yang Rui Hai Liu Linna Halim | 2009 | LWT-Food Science and Technology2009，，42： | 1 |
| 13 | Antioxidant and anti- proliferative activities of common edible nut seeds 显示文摘 | Jun Yang Rui Hai Liu Linna Halim | 2009 | LWT-Food Science and Technology2009，，42： | 1 |
| 14 | Fabrication of agarose hydrogel with patterned silver nanowiresfor motion sensor显示文摘In this work, a facile strategy is proposed to construct stretchable electronics based on agarose hydrogels. The hot agarose solution is casted onto a template with patterned Ag nanowires, endowing agarose hydrogel with patterned conductive surface. After further heating treatment, Ag nanowires can be embedded into the agarose hydrogel, which improves the stability of Ag pattern and has no obvious e ffect on the conductivity of hydrogels. The agarose hydrogel with patterned Ag nanowires is certi fied to be an e ffective stretchable electrode to record the motion of joints, which has great potential applications in the field of wearable devices. | Qingquan Han Yang Chen Wei Song Milin Zhang Shengtao Wang Peng Ren Linna Hao Anhe Wang Shuo Bai Jian Yin | 2019 | Bio-Design and Manufacturing2019，2，4： | 1 |
| 15 | DCLK1 autoinhibition and activation in tumorigenesis显示文摘Doublecortin-like kinase 1(DCLK1)is upregulated in many tumors and is a marker for tumor stem cells.Accumulating evidence suggests DCLK1 constitutes a promising drug target for cancer therapy.However,the regulation of DCLK1 kinase activity is poorly understood,particularly the function of its autoinhibitory domain(AID),and,moreover,no physiological activators of DCLK1 have presently been reported.Here we determined the first DCLK1 kinase structure in the autoinhibited state and identified the neuronal calcium sensor HPCAL1 as an activator of DCLK1.The C-terminal AID functions to block the ATP-binding site and is competitive with ATP.HPCAL1 binds directly to the AID in a Ca^(2+)-dependent manner,which releases the autoinhibition.We also analyzed cancer-associated mutations occurring in the AID and elucidate how these mutations disrupt DCLK1 autoinhibition to elicit kinase activity upregulation.Our results present a molecular mechanism for autoinhibition and activation of DCLK1 kinase activity and provide insights into DCLK1-associated tumorigenesis. | Linna Cheng Zejing Yang Wenhao Guo Chengyong Wu Shufang Liang Aiping Tong Zhongwei Cao Rick F.Thorne Sheng-Yong Yang Yamei Yu Qiang Chen | 2022 | The Innovation2022，3，1： | 1 |
| 16 | Adaptive Optimal Output Regulation of Interconnected Singularly Perturbed Systems With Application to Power Systems显示文摘This article studies the adaptive optimal output regulation problem for a class of interconnected singularly perturbed systems(SPSs) with unknown dynamics based on reinforcement learning(RL).Taking into account the slow and fast characteristics among system states,the interconnected SPS is decomposed into the slow time-scale dynamics and the fast timescale dynamics through singular perturbation theory.For the fast time-scale dynamics with interconnections,we devise a decentralized optimal control strategy by selecting appropriate weight matrices in the cost function.For the slow time-scale dynamics with unknown system parameters,an off-policy RL algorithm with convergence guarantee is given to learn the optimal control strategy in terms of measurement data.By combining the slow and fast controllers,we establish the composite decentralized adaptive optimal output regulator,and rigorously analyze the stability and optimality of the closed-loop system.The proposed decomposition design not only bypasses the numerical stiffness but also alleviates the high-dimensionality.The efficacy of the proposed methodology is validated by a load-frequency control application of a two-area power system. | Jianguo Zhao Chunyu Yang Weinan Gao Linna Zhou Xiaomin Liu | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，3： | 0 |
| 17 | Isoliquiritigenin inhibits Ishikawa endometrial carcinoma cells proliferation and promotes apoptosis显示文摘Endometrial cancer is the fourth most frequent neoplasia i women worldwide,and the molecular mechanisms involved in the etiology and pathogenesis continue to be investigated.Isoliquiritigenin(ISL),an important flavonoid isolated from Glycyrrhizae radix,possesses a wide range of pharmacological properties such as antioxidant,antiinflammatory,antitumor and immunoreg ulatory activities.This study aimed to investigate the molecular mechanisms of ISL on the proliferation and apoptosis resistance of Ishikawa endometrial carcinoma cells. | Yao Lijie Jiang Yang Ma Yong Guo Linna Jin Haifeng | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 18 | Inhibition of lysine-specific demethylase 1(LSD1)prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma显示文摘Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell proliferation,migration,and invasion by regulating chromatin morphology and gene expression,and is closely related to the development of non-small cell lung cancer(NSCLC).1 However,the underlying mechanism of LSD1 on cell proliferation and migration remains unclear. | Pengxing He Linna Du Pan Hao Han Yang Yufei Ren Huiqin Kang Yanli Ding Wen Zhao Yichao Xu Hongmin Liu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 19 | Modulating surface cation vacancies of nickel-cobalt oxides as efficient catalysts for lithium-oxygen batteries显示文摘Rechargeable lithium-oxygen batteries(LOBs)have received incremental attention owing to their high energy density and applicability to mobile devices and electric vehicles.However,the lack of robust,low-cost,and environmentally benign bifunctional catalysts is a major impediment to the commercial application.The introduction of vacancies is one of the effective strategies to enhance the performance of cathode catalysts for lithium-oxygen batteries,but the preparation is complicated.In this work,needle-like microsphere cathode catalysts of nickel-cobalt oxide containing cationic vacancies are constructed by controlling the annealing temperature.It is demonstrated that the presence of cationic vacancies can modulate the electronic structure of the catalyst,reduce the energy barrier for the oxygen electrode re-action,meanwhile enhance the bifunctional catalytic activity.Impressively,the nickel-cobalt oxide-based LOB with cationic vacancies exhibits large specific capacity(12,205 mAh g^(-1)at 200 mA g^(-1))and good durability.This work provides worthwhile insight into the formation and catalytic enhancement mech-anism of transition metal oxide catalysts with cationic vacancies,and to some extent,the creation of efficient and low-cost oxygen electrocatalysts for LOBs. | Yuan Yang Linna Dai Jianwei Qiu Zhibiao Hu Peng Wang Yongtao Zhao Huanhuan Guo Pengchao Si Rui Song | 2023 | Journal of Materials Science & Technology2023，，8： | 0 |
| 20 | A cis-eQTL in NSUN2 promotes esophageal squamous-cell carcinoma progression and radiochemotherapy resistance by mRNA-m^(5)C methylation显示文摘Dear Editor,Esophageal squamous cell carcinoma(ESCC)has poor prognosis because of the difficulty in early detection and low sensitivity of advanced disease to radiochemotherapy.1,2 ESCC presents a high proportion of primary resistance to radiochemotherapy,2which may be due to certain individual genetic variations.Expression quantitative trait loci(eQTLs)as proximal and continuous cellular phenotypes have been shown to be helpful to determine how genetic variants may influence phenotype. | Xiangjie Niu Linna Peng Weiling Liu Chuanwang Miao Xinjie Chen Jiahui Chu Xinyu Yang Wen Tan Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员