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您的检索式：作者名="Linyan Wan"
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| 1 | Design and performance of the LLRF control system for CSNS linac显示文摘Objective The China Spallation Neutron Source(CSNS)linac is designed with beam energy of 80 MeV and a peak current of 15 mA in the first phase.It consists of RFQ,two bunchers of medium-energy beam transmission line,four DTL tanks and one debuncher of linac-to-ring beam transmission line.Correspondingly,eight online RF power sources are used to power these accelerators.In order to stabilize the amplitude,phase and resonant frequency of the RF accelerating field,and minimize beam loss,we have established digital low-level RF(LLRF)control system.Methods The LLRF system includes RF reference line,analog module(AM),clock distribution module,digital control module(DCM),high-power protection module,timing and RF interlock module and so on.The DCM is mainly responsible for the stability of the RF field amplitude and phase,and RF interlock module can quickly cut off the RF drive in case of arc in the RF transmission system,VSWR over threshold or cavity vacuum fault and so on.Result During beam commissioning,all of eight online units of LLRF control system were operating stably and reliably.The amplitude and phase variations of the linac fields have been achieved about±0.4%and±0.15°with 10-mA beam loading,much better than the design requirements of±1%in amplitude and±1°in phase.Conclusion With the help of this system,we achieved stable operation under different beam loads.Also,many important progresses have been achieved in the LLRF control system for amore convenient operation and a higher stability performance.This article describes the design and implementation of the LLRF for CSNS linac. | Linyan Rong Zhencheng Mu Jian Li Zhexin Xie Wenzhong Zhou Bo Wang Maliang Wan Meifei Liu Xinan Xu | 2020 | Radiation Detection Technology and Methods2020，4，2： | 1 |
| 2 | Inhibition of the AKT/mTOR pathway negatively regulates PTEN expression via miRNAs显示文摘PI3K/AKT/mTOR pathway plays important roles in cancer development,and the negative role of PTEN in the PI3K/AKT/mTOR pathway is well known,but whether PTEN can be inversely regulated by PI3K/AKT/mTOR has rarely been reported.Here we aim to investigate the potential regulatory relationship between PTEN and Akt/mTOR inhibition in MEFs.AKT1^(E17K) and TSC2^(–/–)MEFs were treated with the AKT inhibitor MK2206 and the mTOR inhibitors rapamycin and Torin2.Our results reveal that inhibition of AKT or mTOR suppresses PTEN expression in AKT1E17K and TSC2^(–/–)MEFs,but the transcription,subcellular localization,eIF4E-dependent translational initiation or lysosome-and proteasome-mediated degradation of PTEN change little,as shown by the real time PCR,nucleus cytoplasm separation assay and immunofluorescence analysis.Moreover,mTOR suppression leads to augmentation of mouse PTEN-3′UTR-binding miRNAs,including miR-23a-3p,miR-23b-3p,miR-25-3p and miR-26a-5p,as shown by the dual luciferase reporter assay and miRNA array analysis,and miRNA inhibitors collaborately rescue the decline of PTEN level.Collectively,our findings confirm that inhibition of mTOR suppresses PTEN expression by upregulating miRNAs,provide a novel explanation for the limited efficacy of mTOR inhibitors in the treatment of mTOR activation-related tumors,and indicate that dual inhibition of mTOR and miRNA is a promising therapeutic strategy to overcome the resistance of mTOR-related cancer treatment. | Linyan Wan Yanan Wang Jie Li Yani Wang Hongbing Zhang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 3 | The Research and Analysis of Semi-worsted Yarns under Compact Spinning Model显示文摘 | Weilai Chen Weihong Zhan Linyan Wan | 2014 | 材料科学研究(中英文版)2014，3，4： | 0 |
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