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| 1 | Development of SSR markers from ESTs of gramineous species and their chromosome location on wheat显示文摘407,663 的一个总数表示了小麦,大麦,玉米,米饭,和蜀黍的顺序标签(EST ) ,从 GenBank/dbEST 获得了,被用来寻找简单顺序重复(SSR ) 。10,253 EST-SSRs 的一个总数,说明了 2.52% 所有 EST,被识别。用教材首相 5.0, 1367 EST-SSR 教材对被设计,哪个 715 与高质量被综合。 715 教材对在五庄稼在一样的 PCR 条件,和有效教材对下面在小麦,米饭,玉米,棉花,和大豆上被测试是 500 (69.93%), 383 (53.57%), 452 (63.22%), 357 (49.93%),并且 388 (56.27%)分别地。这显示了在扩及远距离的种类之间的 EST-SSR 标记的高可转移性。另外,有 240 loci 的 139 EST-SSR 教材对在由使用小麦的中国春天 nulli-tetrasomic 线的所有 21 个小麦染色体上是局部性的。 | Linzhi Li Junjun Wang Ying Guo Fangshan Jiang Yunfeng Xu Yingying Wang Haitao Pan Guanzhu Han Ruijun Li Sishen Li | 2008 | Progress in Natural Science:Materials International2008，18，12： | 25 |
| 2 | A virus-derived siRNA activates plant immunity by interfering with ROS scavenging显示文摘Virus-derived small interference RNAs(vsiRNAs)not only suppress virus infection in plants via induction of RNA silencing but also enhance virus infection by regulating host defensive gene expression.However,the underlying mechanisms that control vsiRNA-mediated host immunity or susceptibility remain largely unknown.In this study,we generated several transgenic wheat lines using four artificial microRNA expression vectors carrying vsiRNAs from Wheat yellow mosaic virus(WYMV)RNA1.Laboratory and field tests showed that two transgenic wheat lines expressing amiRNAI were highly resistant to WYMV infection.Further analyses showed that vsiRNAI could modulate the expression of a wheat thioredoxin-like gene(TaAAEDI),which encodes a negative regulator of reactive oxygen species(ROS)production in the chloroplast.The function of TaAAEDI in ROS scavenging could be suppressed by vsiRNAI in a dose-dependent manner.Furthermore,transgenic expression of amiRNAI in wheat resulted in broad-spectrum disease resistance to Chinese wheat mosaic virus,Barley stripe mosaic virus,and Puccinia striiformis f.sp.tritici infection,suggesting that vsiRNAI is involved in wheat immunity via ROS signaling.Collectively,these findings reveal a previously unidentified mechanism underlying the arms race between viruses and plants. | Peng Liu Xiaoxiang Zhang Fan Zhang Miaoze Xu Zhuangxin Ye Ke Wang Shuang Liu Xiaolei Han Ye Cheng Kaili Zhong Tianye Zhang Linzhi Li Youzhi Ma Ming Chen Jianping Chen Jian Yang | 2021 | Molecular Plant2021，14，7： | 1 |
| 3 | SETD2 mediates immunotherapy and radiotherapy efficacy via regulating DNA damage responses and genomic stability in lung adenocarcinoma显示文摘SETD2 is the main transferase for the trimethylation of histone H3 at lysine 36 (H3K36me3) in mammals. SETD2 plays important role in repairing DNA double strand breaks and maintaining chromatin integrity.1 In renal carcinoma, SETD2 deficiency caused DNA replication fork instability and DNA damage.2 The absence of SETD2 was also reported to have strong tumor-promoting effects in lung adenocarcinomas (LUAD).3 However, the other roles of SETD2 remain poorly understood in LUAD. In this study, we utilized comprehensive omics-data analysis to determine that SETD2 was associated with DNA damage and immune-related signals in LUAD. SETD2 knockdown induced DNA damage and cGAS activation in LUAD cells, and reduced the number of cells at the G1 phase. Moreover, SETD2 deficiency was conducive to mutation burden, immune cell infiltration, and immunotherapy responses. High SETD2 expression was associated with high radiocurability. These findings suggest that SETD2 may be a promising biomarker of therapeutic responses for LUAD patients, and offer novel insights into immunotherapy and radiotherapy. | Zihang Zeng Yanping Gao Jiali Li Jianguo Zhang Yangyi Li Fajian He Zhengrong Huang Linzhi Han Yan Gong Conghua Xie | 2023 | Genes & Diseases2023，10，2： | 0 |
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