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| 1 | Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats显示文摘 | Ji-ye AA Guang-ji WANG Hai-ping HAO Qing HUANG Yi-hong LU Bei YAN Wei-bin ZHA Lin-sheng LIU An KANG | 2010 | Acta Pharmacologica Sinica2010，31，8： | 14 |
| 2 | Rebalancing of the gut flora and microbial metabolism is responsible for the anti-arthritis effect of kaempferol显示文摘Kaempferol is a natural flavonol that possesses various pharmacological activities,including anti-arthritis effects,yet the underlying mechanisms remain controversial.To evaluate the anti-arthritis efficacy and the underlying mechanisms of kaempferol,collagen-induced arthritis(CIA)mice were treated with kaempferol intragastrically(200 mg·kg^−1·d^−1)and intraperitoneally(20 mg·kg^−1·d^−1).Pharmacodynamic and pharmacokinetic studies showed that the oral administration of kaempferol produced distinct anti-arthritis effects in model mice with arthritis in terms of the spleen index,arthritis index,paw thickness,and inflammatory factors;the bioavailability(1.5%,relative to that of the intraperitoneal injection)and circulatory exposure of kaempferol(Cmax=0.23±0.06 ng/mL)and its primary metabolite kaempferol-3-O-glucuronide(Cmax=233.29±89.64 ng/mL)were rather low.In contrast,the intraperitoneal injection of kaempferol caused marginal anti-arthritis effects,although it achieved a much higher in vivo exposure.The much higher kaempferol content in the gut implicated a potential mechanism involved in the gut.Analysis of 16S ribosomal RNA revealed that CIA caused imbalance of 14 types of bacteria at the family level,whereas kaempferol largely rebalanced the intestinal microbiota in CIA mice.A metabolomics study showed that kaempferol treatment significantly reversed the perturbation of metabolites involved in energy production and the tryptophan,fatty acid and secondary bile acid metabolisms in the gut contents of the CIA mice.In conclusion,we demonstrate for the first time that the high level of kaempferol in the gut regulates the intestinal flora and microbiotic metabolism,which are potentially responsible for the anti-arthritis activities of kaempferol. | Li-xiang Aa Fei Fei Qi Qi Run-bin Sun Sheng-hua Gu Zi-zhen Di Ji-ye Aa Guang-ji Wang Chang-xiao Liu | 2020 | Acta Pharmacologica Sinica2020，41，1： | 9 |
| 3 | 血压变异性预测自发性脑出血患者的院内不良预后显示文摘越来越多的证据表明,较高的收缩压变异性(systolicblood pressure variability ,SBPV)可能与脑出血患者的不良预后相关。该研究探讨了 SB PV 与院内脑出血预后之间的关系。研究者在2个医疗系统中收集了10年的自发性脑出血患者的连续数据。记录人口统计学、病史、实验室测试、计算机断层扫描数据、院内治疗情况以及神经和功能评估。在入院后24h内获取血压记录。 | 刘青 叶鹏 Divani AA Liu X Di Napoli M Lattanzi S Ziai W James ML Jafarli A Jafari M Saver JL Hemphill JC Vespa PM Mayer SA Petersen A | 2019 | 中华高血压杂志2019，27，8： | 6 |
| 4 | Pharmacokinetic interactions between 20(S)- ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo显示文摘 | Jian SHI Bei CAO Wei-bin ZHA Xiao-lan WU Lin-sheng LIU Wen-jing XIAO Rong-rong GU Run-bin SUN Xiao-y YU Tian ZHENG Meng-jie LI Xin-wen WANG Jun ZHOU Yong MAO Chun GE Ting MA Wen-juan XIA Ji-ye AA Guang-ji WANG Chang-xiao LIU | 2013 | Acta Pharmacologica Sinica2013，34，10： | 3 |
| 5 | Hormonal control of androgen receptor function through Sirtl 显示文摘 | Fu M Liu M Sauve AA | 2006 | Mol Cell Biol2006，26，21： | 1 |
| 6 | Stereoselective coupling of hemigossypol to form (+)-gossypol in moco cotton is mediated by a dirigent protein显示文摘 | Liu JG Stipanovic RD Bell AA | 2008 | Phytochemistry2008，69，18： | 1 |
| 7 | Cloning and sequencing of eDNA encoding human DNA topoisomerase Ⅱ and localization of the gene to chromosome region 17q21 -22 显示文摘 | Tsai - pflugfelder M Liu LF Liu AA | 1988 | Prec Natl Acad Sci1988，85，： | 1 |
| 8 | Postoperative compli- catiolas associated with dural substitutes in suboccipital cranioto- mies 显示文摘 | MOSKOWITZ SI LIU J KRISHNANEY AA | 2009 | Neurosurgery2009，64，3： | 1 |
| 9 | Amplification of the DNA polymerase I gene of Treponema pallidum from whole blood of persons with syphilis显示文摘 | Marfin AA Liu H Sutton MY | 2001 | Diagn Microbiol Infect Dis2001，40，4： | 1 |
| 10 | Amplification of the DNA polymerase I gene of Treponema pallidum from whole blood of persons with syphilis显示文摘 | Martin AA Liu H Sutton MY | 2001 | Diagn Microbiol Infect Dis2001，40，： | 1 |
| 11 | Cephalometric comparisons between Chinese and Caucasian patients with obstructive sleep apnea 显示文摘 | Liu Y Lowe AA Zeng X | 2000 | Am J Orthod Dentofacial Orthop2000，117，4： | 1 |
| 12 | Demographic differencesand trends of vitamin D insufficiency in the US population,1988-2004显示文摘 | Ginde AA Liu MC Camargo CA Jr | 2009 | Arch Intern Med2009，169，6： | 1 |
| 13 | Demographic differences and trends of vitamin 0 insufficiency in the US population, 1988-2004显示文摘 | Ginde AA Liu MC Camargo CAJr | 2009 | Arch Intern Med2009，169，6： | 1 |
| 14 | Endorectal color and duplex imaging of the normal rectal wall and rectal masses显示文摘 | Alexander AA Liu JB Palazzo JP | 1994 | J Ultrasound Med1994，13，7： | 1 |
| 15 | Single sheet functionalized graphene by oxidation and thermal expansion of graphite 显示文摘 | McAllister MJ Li JL Adamson DH Schniepp HC Abdala AA Liu J Herrare-Alonso M Milius DL | 2007 | Chem Mater2007，19，： | 1 |
| 16 | Oral status and oral mucosa blood circulation changes in patients with chron- ic heart failure 显示文摘 | LIu O Rybakova MG Barmasheva AA | 2013 | Stomatologiia ( Mosk)2013，92，4： | 1 |
| 17 | Encdorectal color and daplex imaging of the normal rectal wall and rectal masses显示文摘 | Alexander AA Liu JB Palazzo JR | 1999 | J Ultrasound Med1999，13，7： | 1 |
| 18 | A correlation of radiographic and functional measurements in adult degenerative scoliosis 显示文摘 | Ploumis A Liu H Mehbod AA | 2009 | Spine( Phila Pa 1976 )2009，34，15： | 1 |
| 19 | Heme-oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice显示文摘 | Chung SW Liu X Macias AA | | 0，，01： | 1 |
| 20 | Cephalometric comparisons between Chinese and Caucasian patients with obstructive sleep apnea显示文摘 | Liu Y Lowe AA Zeng X | 2000 | A m J Ort hod Dentofac Orthop2000，117，4： | 1 |
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